日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery

利用细胞色素P450人源化小鼠模型改进血吸虫病药物研发

Davey, Sarah D; Forde-Thomas, Josephine E; Hulme, Benjamin J; Lees, Kristin; Costain, Alice H; Evans, Mary; Rinaldi, Gabriel; Frame, Laura; Stojanovski, Laste; Simeons, Frederick R C; Tavendale, Amy; MacLeod, A Kenneth; Pichon, Remi; Lee, Yi-Hsuan; Polak, Oktawia; Chalmers, Iain W; Dankwa, Bismark; Odhiambo, Brenda Kisia; Guimaraes, Victor Hugo; Hegarty, Matthew; Swain, Martin T; Aubrey, Wayne; Caldwell, Nicola; MacDonald, Andrew S; Gilbert, Ian H; Baragaña, Beatriz; Read, Kevin D; Hoffmann, Karl F

Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations

单细胞RNA测序揭示克氏锥虫群体中转唾液酸酶样超家族基因表达的异质性

Inchausti, Lucas; Bilbao, Lucia; Campo, Vanina A; Garat, Joaquín; Sotelo-Silveira, José; Rinaldi, Gabriel; Howick, Virginia M; Duhagon, Maria A; De Gaudenzi, Javier G; Smircich, Pablo

Transcriptome profiling of intra-snail stages of the liver fluke Fasciola hepatica reveals key mediators underlying parasite development and interaction with the host

对肝片吸虫(Fasciola hepatica)在螺体内发育阶段的转录组分析揭示了寄生虫发育及其与宿主相互作用的关键调控因子

Langleib, Mauricio; Fontenla, Santiago; Domínguez, Fernanda; Sankaranarayanan, Geetha; Wlodek, Sabina; Berriman, Matt; Rinaldi, Gabriel; Iriarte, Andrés; Tort, José F

The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni.

通过对卵巢细胞进行单细胞转录组学分析发现的视黄酸家族样核受体 SmRAR 控制曼氏血吸虫卵母细胞的分化

Moescheid Max F, Lu Zhigang, Soria Carmen Diaz, Quack Thomas, Puckelwaldt Oliver, Holroyd Nancy, Holzaepfel Pauline, Haeberlein Simone, Rinaldi Gabriel, Berriman Matthew, Grevelding Christoph G

A single-cell atlas of the miracidium larva of Schistosoma mansoni reveals cell types, developmental pathways, and tissue architecture.

曼氏血吸虫毛蚴的单细胞图谱揭示了细胞类型、发育途径和组织结构

Attenborough Teresa, Rawlinson Kate A, Diaz Soria Carmen L, Ambridge Kirsty, Sankaranarayanan Geetha, Graham Jennie, Cotton James A, Doyle Stephen R, Rinaldi Gabriel, Berriman Matthew

Editorial: Stem cell technologies meet stem cell biology to shine new light into tropical infectious diseases

社论:干细胞技术与干细胞生物学相结合,为热带传染病研究带来新曙光

Pance, Alena; Rinaldi, Gabriel

Single-cell transcriptomics of the human parasite Schistosoma mansoni first intra-molluscan stage reveals tentative tegumental and stem-cell regulators

人类寄生虫曼氏血吸虫第一期软体动物体内阶段的单细胞转录组学研究揭示了表皮和干细胞的初步调控因子

Diaz Soria, Carmen L; Attenborough, Teresa; Lu, Zhigang; Fontenla, Santiago; Graham, Jennie; Hall, Christopher; Thompson, Sam; Andrews, Toby G R; Rawlinson, Kate A; Berriman, Matthew; Rinaldi, Gabriel

The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle

曼氏血吸虫(Schistosoma mansoni)在其整个生命周期中都携带细菌。

Formenti, Fabio; Cortés, Alba; Deiana, Michela; Salter, Susannah; Parkhill, Julian; Berriman, Matt; Rinaldi, Gabriel; Cantacessi, Cinzia

Screening of a Library of Recombinant Schistosoma mansoni Proteins With Sera From Murine and Human Controlled Infections Identifies Early Serological Markers

利用小鼠和人类受控感染血清筛选重组曼氏血吸虫蛋白库,可鉴定早期血清学标志物

Crosnier, Cécile; Hokke, Cornelis H; Protasio, Anna V; Brandt, Cordelia; Rinaldi, Gabriel; Langenberg, Marijke C C; Clare, Simon; Janse, Jacqueline J; Wilson, Shona; Berriman, Matthew; Roestenberg, Meta; Wright, Gavin J

The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis

肠道微生物代谢能力在人源化啮齿动物和野生型啮齿动物中的比较揭示了肠道细菌在肝肠血吸虫病中可能发挥的双重作用。

Cortés, Alba; Martin, John; Rosa, Bruce A; Stark, Klara A; Clare, Simon; McCarthy, Catherine; Harcourt, Katherine; Brandt, Cordelia; Tolley, Charlotte; Lawley, Trevor D; Mitreva, Makedonka; Berriman, Matthew; Rinaldi, Gabriel; Cantacessi, Cinzia