日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma.

IGSF11-VISTA 是弥漫性中线胶质瘤中一个关键且可靶向的免疫检查点轴。

Collot Raphaël, Ruiz-Moreno Cristian, Honhoff Celina, van den Broek Thijs J M, Wezenaar Amber K L, Kloosterman Daan J, Ariese Hendrikus C R, Johnson Hannah, Vervoort Britt M T, Jeiroshi Amal, Bunt Jens, van Ineveld Ravian L, Bokobza Emma, Rebel Heggert G, Te Pas Brigit M, Ringnalda Femke C A, van de Wetering Marc, Robe Pierre A, Kool Marcel, Cochran Jennifer R, Kranendonk Mariëtte E G, van Vuurden Dannis G, Hulleman Esther, Wehrens Ellen J, Zomer Anoek, Stunnenberg Hendrik G, Rios Anne C

Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages

舌后部的三能性Lgr5干细胞可分化生成舌腺、味腺和唾液腺谱系。

Laurens H G Verweij #,Seok-Young Kim #,Dimitrios Laskaris,Lin Lin,Gijs J F van Son,Femke C A S Ringnalda,Harry Begthel,Ravian L van Ineveld,Chris Winkel,Jay P Slack,Anne C Rios,Karin Sanders,Jacco van Rheenen,Marc van de Wetering,Hans Clevers

Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition

小圆细胞肉瘤类肿瘤生物样本库揭示了CIC::DUX4肉瘤对MCL-1抑制剂的敏感性

Femke C A S Ringnalda ,Gijs J F van Son ,Laurens H G Verweij ,Seok-Young Kim ,Vicky Amo-Addae ,Uta E Flucke ,Laura S Hiemcke-Jiwa ,Karin P S Langenberg ,Jos A M Bramer ,Lotte Heimans ,Michiel A J van de Sande ,Winan J van Houdt ,Max M van Noesel ,Hinri H D Kerstens ,Marcel Santoso ,Georg Seifert ,Olivier Delattre ,Katia Scotlandi ,Birgit Geoerger ,Johannes H M Merks ,Jan J Molenaar ,Ruben van Boxtel ,Marc van de Wetering ,Karin Sanders # ,Hans Clevers #

Organoid drug profiling identifies methotrexate as a therapy for SCCOHT, a rare pediatric cancer

类器官药物分析确定甲氨蝶呤可作为治疗罕见儿童癌症 SCCOHT 的药物

Seok-Young Kim, Tamar A E de Weert, Marijn Vermeulen, Femke Ringnalda, Lennart Kester, Jozsef Zsiros, Selma Eising, Jan J Molenaar, Karin Sanders, Marc van de Wetering, Hans Clevers

Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids.

肝母细胞瘤肿瘤和类器官中 WNT 信号传导和药物敏感性特征的差异

Kluiver Thomas A, Lu Yuyan, Schubert Stephanie A, Kraaier Lianne J, Ringnalda Femke, Lijnzaad Philip, DeMartino Jeff, Megchelenbrink Wouter L, Amo-Addae Vicky, Eising Selma, de Faria Flavia W, Münter Daniel, van de Wetering Marc, Kerl Kornelius, Duiker Evelien, van den Heuvel Marius C, de Meijer Vincent E, de Kleine Ruben H, Molenaar Jan J, Margaritis Thanasis, Stunnenberg Hendrik G, de Krijger Ronald R, Zsiros József, Clevers Hans, Peng Weng Chuan

Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

非典型畸胎瘤样/横纹肌样肿瘤样肿瘤揭示了亚组特异性的药物脆弱性

Irene Paassen, Justin Williams, Carla Ríos Arceo, Femke Ringnalda, Kimberly Shea Mercer, Juliane L Buhl, Natalia Moreno, Aniello Federico, Niels E Franke, Mariette Kranendonk, Santhosh A Upadhyaya, Kornelius Kerl, Marc van de Wetering, Hans Clevers, Marcel Kool, Eelco W Hoving, Martine F Roussel, Ja

Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment

人类胰腺癌类器官中的药物筛选和基因组编辑可确定药物-基因相互作用和标外治疗候选药物

Christian K Hirt, Tijmen H Booij, Linda Grob, Patrik Simmler, Nora C Toussaint, David Keller, Doreen Taube, Vanessa Ludwig, Alexander Goryachkin, Chantal Pauli, Daniela Lenggenhager, Daniel J Stekhoven, Christian U Stirnimann, Katharina Endhardt, Femke Ringnalda, Lukas Villiger, Alexander Siebenhüne

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

肝细胞体内胞苷碱基编辑,RNA 和 DNA 中未检测到脱靶突变

Lukas Villiger #, Tanja Rothgangl #, Dominik Witzigmann, Rurika Oka, Paulo J C Lin, Weihong Qi, Sharan Janjuha, Christian Berk, Femke Ringnalda, Mitchell B Beattie, Markus Stoffel, Beat Thöny, Jonathan Hall, Hubert Rehrauer, Ruben van Boxtel, Ying K Tam, Gerald Schwank3

Canine Pituitary Organoids as 3D In Vitro Model for Cushing Disease

犬垂体类器官作为库欣病的三维体外模型

Stolzenbach, Lara Franziska; Fankhauser, Christian D; Mattei, Agostino; Würnschimmel, Christoph; Sanders, Karin; Ringnalda, Femke C A; van de Wetering, Marc L; Kooistra, Hans S; Meij, Björn P; Clevers, Hans; Galac, Sara

EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model

在新型 DSRCT 体外模型中确定 EWSR1-WT1 靶基因和治疗方案

Margit Bleijs, Corine Pleijte, Sem Engels, Femke Ringnalda, Friederike Meyer-Wentrup, Marc van de Wetering, Hans Clevers