日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules

发现并鉴定出一种新型高效 MDM2-p53 拮抗剂 Brigimadlin,该药适用于间歇给药方案

Andreas Gollner #, Dorothea Rudolph #, Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Peter Jung, Harald Weinstabl, Jürgen Ramharter, Rolf Grempler, Jens Quant, Jörg Rinnenthal, Alejandro Pérez Pitarch, Bojana Golubovic, Daniel Gerlach, Gerd Bader, Kristiane Wetzel, Sebastian Otto, Christian Mandl, 

BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models

BI-907828 是一种新型强效 MDM2 抑制剂,可在体外抑制胶质母细胞瘤脑肿瘤干细胞并延长原位异种移植小鼠模型中的生存期

Xiaoguang Hao, Ravinder K Bahia, Orsolya Cseh, Danielle A Bozek, Sophia Blake, Jörg Rinnenthal, Ulrike Weyer-Czernilofsky, Dorothea Rudolph, H Artee Luchman

Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist

使用新型保肝 TRAILR2 激动剂 BI 905711 在 CDH17 阳性结直肠癌模型中实现肿瘤细胞选择性凋亡和肿瘤消退

Juan Manuel García-Martínez, Shirley Wang, Cordula Weishaeupl, Andreas Wernitznig, Paolo Chetta, Catarina Pinto, Jason Ho, Darrin Dutcher, Philip N Gorman, Rachel Kroe-Barrett, Joerg Rinnenthal, Craig Giragossian, Maria Antonietta Impagnatiello, Iñigo Tirapu, Frank Hilberg, Norbert Kraut, Mark Pears

Neurochemical Differences in Spinocerebellar Ataxia Type 14 and 1

14型和1型脊髓小脑性共济失调的神经化学差异

Grosch, Anne Sophie; Rinnenthal, Jan Leo; Rönnefarth, Maria; Lux, Silke; Scheel, Michael; Endres, Matthias; Brandt, Alexander U; Paul, Friedemann; Schmitz-Hübsch, Tanja; Minnerop, Martina; Doss, Sarah

The Amyloid-beta rich CNS environment alters myeloid cell functionality independent of their origin

富含β-淀粉样蛋白的中枢神经系统环境会改变髓系细胞的功能,而与它们的来源无关。

Natalia Drost # ,Judith Houtman # ,Zoltán Cseresnyés ,Raluca Niesner ,Jan-Leo Rinnenthal ,Kelly R Miller ,Stefan Prokop ,Frank L Heppner

Drugging an undruggable pocket on KRAS

对 KRAS 上的一个无法用药的口袋进行药物治疗

Kessler, Dirk; Gmachl, Michael; Mantoulidis, Andreas; Martin, Laetitia J; Zoephel, Andreas; Mayer, Moriz; Gollner, Andreas; Covini, David; Fischer, Silke; Gerstberger, Thomas; Gmaschitz, Teresa; Goodwin, Craig; Greb, Peter; Häring, Daniela; Hela, Wolfgang; Hoffmann, Johann; Karolyi-Oezguer, Jale; Knesl, Petr; Kornigg, Stefan; Koegl, Manfred; Kousek, Roland; Lamarre, Lyne; Moser, Franziska; Munico-Martinez, Silvia; Peinsipp, Christoph; Phan, Jason; Rinnenthal, Jörg; Sai, Jiqing; Salamon, Christian; Scherbantin, Yvonne; Schipany, Katharina; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Siszler, Gabriella; Sun, Qi; Waterson, Alex; Wolkerstorfer, Bernhard; Zeeb, Markus; Pearson, Mark; Fesik, Stephen W; McConnell, Darryl B

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

高度选择性 PTK2 蛋白水解靶向嵌合体以探测粘着斑激酶支架功能

Johannes Popow, Heribert Arnhof, Gerd Bader, Helmut Berger, Alessio Ciulli, David Covini, Christian Dank, Teresa Gmaschitz, Peter Greb, Jale Karolyi-Özguer, Manfred Koegl, Darryl B McConnell, Mark Pearson, Maria Rieger, Joerg Rinnenthal, Vanessa Roessler, Andreas Schrenk, Markus Spina, Steffen Steur

Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome

p63 转录因子的蛋白质聚集是 AEC 综合征中严重皮肤脆弱的原因

Claudia Russo, Christian Osterburg, Anna Sirico, Dario Antonini, Raffaele Ambrosio, Julia Maren Würz, Jörg Rinnenthal, Marco Ferniani, Sebastian Kehrloesser, Birgit Schäfer, Peter Güntert, Satrajit Sinha, Volker Dötsch, Caterina Missero

IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca(2+) uptake during hypocapnia

IDH3介导低碳酸血症期间线粒体Ca(2+)摄取引起的II型肺泡上皮细胞凋亡

Kiefmann, Martina; Tank, Sascha; Keller, Paula; Börnchen, Christian; Rinnenthal, Jan L; Tritt, Marc-Oliver; Schulte-Uentrop, Leonie; Olotu, Cynthia; Goetz, Alwin E; Kiefmann, Rainer

Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment

神经影像生物标志物可预测血管性认知障碍小鼠模型的大脑结构连接变化

Boehm-Sturm, Philipp; Füchtemeier, Martina; Foddis, Marco; Mueller, Susanne; Trueman, Rebecca C; Zille, Marietta; Rinnenthal, Jan Leo; Kypraios, Theodore; Shaw, Laurence; Dirnagl, Ulrich; Farr, Tracy D