日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis

金黄色葡萄球菌通过V8蛋白酶-PAR1轴引发瘙痒和抓挠引起的皮肤损伤。

Liwen Deng ,Flavia Costa ,Kimbria J Blake ,Samantha Choi ,Arundhasa Chandrabalan ,Muhammad Saad Yousuf ,Stephanie Shiers ,Daniel Dubreuil ,Daniela Vega-Mendoza ,Corinne Rolland ,Celine Deraison ,Tiphaine Voisin ,Michelle D Bagood ,Lucia Wesemann ,Abigail M Frey ,Joseph S Palumbo ,Brian J Wainger ,Richard L Gallo ,Juan-Manuel Leyva-Castillo ,Nathalie Vergnolle ,Theodore J Price ,Rithwik Ramachandran ,Alexander R Horswill ,Isaac M Chiu

PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice

PAR4抑制剂可减轻SR-B1/LDLR双敲除小鼠的冠状动脉粥样硬化和心肌纤维化

Samuel K Lee ,Rida A Malik ,Ji Zhou ,Wei Wang ,Peter L Gross ,Jeffrey I Weitz ,Rithwik Ramachandran ,Bernardo L Trigatti

Discovery of Ghrelin(1-8) Analogues with Improved Stability and Functional Activity for PET Imaging

发现具有更高稳定性和 PET 成像功能活性的生长素释放肽 (1-8) 类似物

Marina D Childs, Arundhasa Chandrabalan, Derian Hodgson, Rithwik Ramachandran, Leonard G Luyt

Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

人类骨关节炎膝关节滑液裂解并激活蛋白酶激活受体 (PAR) 介导的信号传导

Arundhasa Chandrabalan, Andrew Firth, Robert B Litchfield, C Thomas Appleton, Alan Getgood, Rithwik Ramachandran

Role of the Helix-8 and C-Terminal Tail in Regulating Proteinase Activated Receptor 2 Signaling

螺旋-8 和 C 末端尾部在调节蛋白酶激活受体 2 信号传导中的作用

Pierre E Thibeault, Rithwik Ramachandran

Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)

凝血酶激活的 GPCR 蛋白酶激活受体 4 (PAR4) 的激活和偏向信号传导的分子基础

Pierre E Thibeault, Jordan C LeSarge, D'Arcy Arends, Michaela Fernandes, Peter Chidiac, Peter B Stathopulos, Leonard G Luyt, Rithwik Ramachandran

The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response

降温化合物 icilin 通过调节 T 细胞反应来减轻自身免疫性神经炎症

Benjamin W Ewanchuk, Euan R O Allan, Amy L Warren, Rithwik Ramachandran, Robin M Yates

Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells

蛋白酶激活受体 2 (PAR2) 减少结肠上皮细胞凋亡

Vadim Iablokov, Christina L Hirota, Michael A Peplowski, Rithwik Ramachandran, Koichiro Mihara, Morley D Hollenberg, Wallace K MacNaughton

Targeting proteinase-activated receptors: therapeutic potential and challenges

靶向蛋白酶激活受体:治疗潜力和挑战

Rithwik Ramachandran, Farshid Noorbakhsh, Kathryn Defea, Morley D Hollenberg

The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation

活性 Zot 结构域 (aa 288-293) 可增加 ZO-1 和肌球蛋白 1C 丝氨酸/苏氨酸磷酸化,改变 ZO-1 与其结合伙伴之间的相互作用,并通过蛋白酶激活受体 2 激活诱导紧密连接分解

Simeon E Goldblum, Usha Rai, Amit Tripathi, Manjusha Thakar, Luigina De Leo, Nicola Di Toro, Tarcisio Not, Rithwik Ramachandran, Adam C Puche, Morley D Hollenberg, Alessio Fasano