The active Zot domain (aa 288-293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation
活性 Zot 结构域 (aa 288-293) 可增加 ZO-1 和肌球蛋白 1C 丝氨酸/苏氨酸磷酸化,改变 ZO-1 与其结合伙伴之间的相互作用,并通过蛋白酶激活受体 2 激活诱导紧密连接分解
期刊:FASEB Journal
影响因子:4.4
doi:10.1096/fj.10-158972
Simeon E Goldblum, Usha Rai, Amit Tripathi, Manjusha Thakar, Luigina De Leo, Nicola Di Toro, Tarcisio Not, Rithwik Ramachandran, Adam C Puche, Morley D Hollenberg, Alessio Fasano