日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wild-Type RAS Activation in Non-Small Cell Lung Cancer

RAS-GTP抑制剂可克服非小细胞肺癌中由致癌性和野生型RAS激活介导的对KRASG12C抑制剂的获得性耐药性

Solanki, Hitendra S; Shah, Harshit; Imbody, Denis; Desai, Bina; Kato, Ryoji; Miroshnychenko, Daria; Stern, Yaakov E; Majumder, Anurima; Sarcar, Bhaswati; Xieraili, Aobuli; Stewart, Paul A; Fang, Bin; Zhang, Yonghong; Yao, Jiqiang; Darville, Lancia N; Koomen, John M; Rix, Uwe; Evans, James W; Yang, Yu Chi; Ahler, Ethan; Marusyk, Andriy; Singh, Mallika; Aronchik, Ida; Haura, Eric B

Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells

RET 和 SRC 双重靶向治疗对 RET 融合阳性癌细胞具有协同作用。

Son, Juhyeon; Remsing Rix, Lily L; Fang, Bin; Welsh, Eric A; Bremer, Nicole V; Foglizzo, Valentina; Roa, Paola; Sigcha-Coello, Nickole; Liao, Yi; Haura, Eric B; Drilon, Alexander; Koomen, John M; Cocco, Emiliano; Rix, Uwe

Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer by concurrent integrin and MET signaling.

癌症相关成纤维细胞通过同时激活整合素和MET信号通路,使EML4-ALK驱动的肺癌对ALK抑制剂产生耐药性。

Hu Qianqian, Remsing Rix Lily L, Desai Bina, Miroshnychenko Daria, Li Xueli, Welsh Eric A, Fang Bin, Wright Gabriela M, Chaudhary Neelkamal, Kroeger Jodi L, Doebele Robert C, Koomen John M, Haura Eric B, Marusyk Andriy, Rix Uwe

Differential Chemoproteomics Reveals MARK2/3 as Cell Migration-Relevant Targets of the ALK Inhibitor Brigatinib

差异化学蛋白质组学揭示 MARK2/3 是 ALK 抑制剂 Brigatinib 的细胞迁移相关靶点

Hu, Qianqian; Liao, Yi; Cao, Jessica; Fang, Bin; Yun, Sang Y; Kinose, Fumi; Haura, Eric B; Lawrence, Harshani R; Doebele, Robert C; Koomen, John M; Rix, Uwe

Turning liabilities into opportunities: Off-target based drug repurposing in cancer

化劣势为机遇:癌症治疗中基于脱靶效应的药物再利用

Palve, Vinayak; Liao, Yi; Remsing Rix, Lily L; Rix, Uwe

Cell Type-specific Adaptive Signaling Responses to KRAS(G12C) Inhibition.

细胞类型特异性适应性信号传导对 KRAS(G12C) 抑制的反应

Solanki Hitendra S, Welsh Eric A, Fang Bin, Izumi Victoria, Darville Lancia, Stone Brandon, Franzese Ryan, Chavan Sandip, Kinose Fumi, Imbody Denis, Koomen John M, Rix Uwe, Haura Eric B

MEK Inhibition Modulates Cytokine Response to Mediate Therapeutic Efficacy in Lung Cancer

MEK抑制剂通过调节细胞因子反应发挥肺癌治疗作用

Xie, Mengyu; Zheng, Hong; Madan-Lala, Ranjna; Dai, Wenjie; Gimbrone, Nicholas T; Chen, Zhihua; Kinose, Fumi; Blackstone, Sarah A; Smalley, Keiran S M; Cress, W Douglas; Haura, Eric B; Rix, Uwe; Beg, Amer A

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model

在小鼠 Ba/F3 模型中对表皮生长因子受体 (EGFR) P848L(一种存在于肺癌患者中的罕见 EGFR 变体)进行表征

Sarcar, Bhaswati; Gimbrone, Nicholas T; Wright, Gabriela; Remsing Rix, Lily L; Gordian, Edna R; Rix, Uwe; Chiappori, Alberto A; Reuther, Gary W; Santiago-Cardona, Pedro G; Muñoz-Antonia, Teresita; Cress, William Douglas

Bidirectional Adaptive Signaling between cancer and stromal cells: mechanisms and therapeutics

癌细胞与基质细胞之间的双向适应性信号传导:机制和治疗方法

Boutchueng-Djidjou, M; Rix, Uwe; Haura, Eric B

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity

AZD1775 通过双重靶向 WEE1 和 PLK1 发挥单药细胞抗癌活性

Wright, Gabriela; Golubeva, Volha; Remsing Rix, Lily L; Berndt, Norbert; Luo, Yunting; Ward, Grace A; Gray, Jhanelle E; Schonbrunn, Ernst; Lawrence, Harshani R; Monteiro, Alvaro N A; Rix, Uwe