日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rapidly acquired HIV-1 neutralization breadth in a rhesus V2 apex knockin mouse model after a single bolus immunization

单次注射免疫后,恒河猴V2顶端敲入小鼠模型迅速获得HIV-1中和广度

Ghosh, Amrit Raj; Habib, Rumi; Mishra, Nitesh; Roark, Ryan S; Akauliya, Madhav; Albowaidey, Ali A; Allen, Joel D; Amereh, Khaled; Avillion, Gabriel; Bottermann, Maria; Liang, Bo; Chaudhary, Namit; Callaghan, Sean; Dye, Jonathan; Li, Xuduo; Ellis-Pugh, Jordan R; Roy Chowdhury, Rohan; James, Nicole E; Liu, Xiaotie; Maiorino, Laura; Villavicencio, Paula M; Nedellec, Rebecca; Oberoi, Prabhgun; Sowers, Kirsten J; Park, Younghoon; Prum, Thavaleak; Rodriguez, Linette; Ssozi, Maria; Torres, Jonathan L; Walsh, Agnes A; Warner, John E; Weldon, Stephanie R; Xu, Liling; Wiehe, Kevin; Crispin, Max; Ward, Andrew B; Nair, Usha; Hahn, Beatrice H; Burton, Dennis R; Shapiro, Lawrence; Kwong, Peter D; Irvine, Darrell J; Andrabi, Raiees; Shaw, George M; Batista, Facundo D

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.

Env抗体共同进化表明B细胞启动是HIV V2顶端广泛中和抗体发展的主要瓶颈。

Habib Rumi, Roark Ryan S, Li Hui, Connell Andrew Jesse, Hogarty Michael P, Wagh Kshitij, Wang Shuyi, Marchitto Lorie, Skelly Ashwin N, Carey John W, Sowers Kirsten J, Ayyanathan Kasirajan, Plante Samantha J, Bibollet-Ruche Frederic, Park Younghoon, Agostino Colby J, Singh Ajay, Martella Christian L, Lewis Emily, Rando Juliette M, Chohan Neha, Lora Jinery, Ding Wenge, Campion Mary S, Zhao Chengyan, Liu Weimin, Li Yingying, Li Xuduo, Liang Bo, Chowdhury Rohan Roy, Amereh Khaled, Van Itallie Elizabeth, Sheng Zizhang, Ghosh Amrit R, Bar Katharine J, Williams Wilton B, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Cain Derek W, Lewis Mark G, Batista Facundo D, Burton Dennis R, Andrabi Raiees, Kulp Daniel W, Haynes Barton F, Korber Bette, Shapiro Lawrence, Kwong Peter D, Hahn Beatrice H, Shaw George M

Vaccine elicitation of HIV-1 neutralizing antibodies against both V2 apex and fusion peptide in rhesus macaques.

在恒河猴中诱导产生针对 V2 顶点和融合肽的 HIV-1 中和抗体的疫苗。

Duan Hongying, Nkolola Joseph P, Wang Shuishu, Chaudhari Jayeshbhai, Teng I-Ting, Lavine Christy, Parchment Danealle K, Sellers George S, McKee Krisha, O'Dell Sijy, Choe Misook, Du Haijuan, Zhang Baoshan, Perez Alejandro A Espinosa, Rossler Annika, Lasrado Ninaad, Biju Andrea, Becker Jordan E, Carroll Robin, Carson Audrey S, Henry Amy R, Morano Nicholas C, Mughal Madeeha, Rawi Reda, Roark Ryan S, Schramm Chaim A, Shen Chen-Hsiang, Smith Sarah C, Stephens Tyler, Tsybovsky Yaroslav, Van Wazer David J, Wang Hua, Yang Yongping, Rutten Lucy, Langedijk Johannes P M, Cheng Cheng, Wang Lingshu, Douek Daniel C, Koup Richard A, Mascola John R, Shapiro Lawrence, Zhou Tongqing, Doria-Rose Nicole A, Korber Bette, Seaman Michael S, Pierson Theodore C, Kwong Peter D, Barouch Dan H

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization.

早期克隆优势决定了 HIV 血清中和的广泛进程。

Liang Bo, Zhu Yuxin, Roark Ryan S, Li Xuduo, Mishra Nitesh, Martella Christian L, Vo Anh L, Giese Gabriella, Huang Qin, Biju Andrea, Tjio Lifei, Chowdhury Rohan Roy, Oberoi Prabhgun, Amereh Khaled, Wani Areeba A, Zhang Yuexiu, Andrabi Sharaf, Sekar Tharunika V, Somanathan Anjali, Kassab Muzaffer, Nedellec Rebecca, Callaghan Sean, Avillion Gabriel, Lewis Mark G, Sackett Sara Dutton, Skelly Ashwin N, Bibollet-Ruche Frederic, Shapiro Lawrence, Sheng Zizhang, Briney Bryan, Hahn Beatrice H, Burton Dennis R, Irvine Darrell J, Kwong Peter D, Shaw George M, Andrabi Raiees

Transient glycan shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.

短暂的聚糖屏障减少可诱导 SHIV 感染的猕猴产生 CD4 结合位点广谱中和抗体

Morris Daniel J, Gorman Jason, Zhou Tongqing, Lora Jinery, Connell Andrew J, Li Hui, Liu Weimin, Roark Ryan S, Campion Mary S, Carey John W, Habib Rumi, Li Yingying, Martella Christian L, Park Younghoon, Singh Ajay, Sowers Kirsten J, Teng I-Ting, Wang Shuyi, Chohan Neha, Ding Wenge, Lauer Craig, Lewis Emily, Mason Rosemarie D, Rando Juliette M, Peyton Lowrey, Schramm Chaim A, Wagh Kshitij, Korber Bette, Seaman Michael S, Douek Daniel C, Haynes Barton F, Kulp Daniel W, Roederer Mario, Hahn Beatrice H, Kwong Peter D, Shaw George M

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

对人类抗体库的深度挖掘发现了可通过疫苗接种靶向的常见且遗传多样性丰富的CDRH3拓扑结构

Habib, Rumi; Solieva, Shahlo O; Lin, Zi Jie; Ghosh, Sukanya; Bayruns, Kelly; Singh, Maya; Agostino, Colby J; Tursi, Nicholas J; Sowers, Kirsten J; Huang, Jinwei; Roark, Ryan S; Purwar, Mansi; Park, Younghoon; Ayyanathan, Kasirajan; Li, Hui; Carey, John W; Kim, Amber; Park, Joyce; McCanna, Madison E; Skelly, Ashwin N; Chokkalingam, Neethu; Kriete, Sinja; Shupin, Nicholas; Huynh, Alana; Walker, Susanne; Sadeesh, Roopak; Laenger, Niklas; Du, Jianqiu; Cui, Jiayan; Patel, Ami; Escolano, Amelia; Kwong, Peter D; Shapiro, Lawrence; Bowman, Gregory R; Hahn, Beatrice H; Shaw, George M; Weiner, David B; Pallesen, Jesper; Kulp, Daniel W

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Env抗体协同进化研究表明,B细胞启动是HIV-1 V2顶端广谱中和抗体产生的主要瓶颈。

Habib, Rumi; Roark, Ryan S; Li, Hui; Connell, Andrew Jesse; Hogarty, Michael P; Wagh, Kshitij; Wang, Shuyi; Marchitto, Lorie; Skelly, Ashwin N; Carey, John W; Sowers, Kirsten J; Ayyanathan, Kasirajan; Plante, Samantha J; Bibollet-Ruche, Frederic; Park, Younghoon; Agostino, Colby J; Singh, Ajay; Martella, Christian L; Lewis, Emily; Rando, Juliette M; Chohan, Neha; Lora, Jinery; Ding, Wenge; Campion, Mary S; Zhao, Chengyan; Liu, Weimin; Li, Yingying; Li, Xuduo; Liang, Bo; Chowdhury, Rohan Roy; Amereh, Khaled; Van Itallie, Elizabeth; Sheng, Zizhang; Ghosh, Amrit R; Bar, Katharine J; Williams, Wilton B; Wiehe, Kevin; Saunders, Kevin O; Edwards, Robert J; Cain, Derek W; Lewis, Mark; Batista, Facundo D; Burton, Dennis R; Andrabi, Raiees; Kulp, Daniel W; Haynes, Barton F; Korber, Bette; Shapiro, Lawrence; Kwong, Peter D; Hahn, Beatrice H; Shaw, George M

Vaccine Elicitation of HIV-1 Neutralizing Antibodies Against Both V2 Apex and Fusion Peptide in Rhesus Macaques

疫苗诱导恒河猴产生针对V2顶点肽和融合肽的HIV-1中和抗体

Duan, Hongying; Nkolola, Joseph P; Wang, Shuishu; Chaudhari, Jayeshbhai; Teng, I-Ting; Lavine, Christy; Parchment, Danealle K; Sellers, George S; McKee, Krisha; O'Dell, Sijy; Choe, Misook; Du, Haijuan; Zhang, Baoshan; Perez, Alejandro A Espinosa; Rossler, Annika; Lasrado, Ninaad; Biju, Andrea; Becker, Jordan E; Carroll, Robin; Carson, Audrey S; Henry, Amy R; Morano, Nicholas C; Mughal, Madeeha; Rawi, Reda; Roark, Ryan S; Schramm, Chaim A; Shen, Chen-Hsiang; Smith, Sarah C; Stephens, Tyler; Tsybovsky, Yaroslav; Van Wazer, David J; Wang, Hua; Yang, Yongping; Rutten, Lucy; Langedijk, Johannes P M; Cheng, Cheng; Wang, Lingshu; Douek, Daniel C; Koup, Richard A; Mascola, John R; Shapiro, Lawrence; Zhou, Tongqing; Doria-Rose, Nicole A; Korber, Bette; Seaman, Michael S; Pierson, Theodore C; Kwong, Peter D; Barouch, Dan H

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.

针对种系 HIV 免疫原的免疫原可诱导非近交系猕猴产生交叉中和抗体。

Mishra Nitesh, Liang Bo, Roark Ryan S, Ghosh Amrit, Callaghan Sean, Lee Wen-Hsin, Li Xuduo, Vo Anh L, Avillion Gabriel, Chowdhury Rohan Roy, Habib Rumi H, Bibollet-Ruche Frederic, Giese Gabriella, Oberoi Prabhgun, Amereh Khaled, Somanathan Anjali, Zhu Yuxin, Zhang Yuexiu, Kassab Muzaffer, Tjio Lifei, Andrabi Sharaf, Reyes Raphael A, Allen Joel D, James Nicole E, Randall Kipchoge N Jr, van der Maas Lara, Ben-Akiva Elana, Kacmarek-Michaels Kasia, Plante Samantha, Martella Christian L, Skelly Ashwin N, Singh Ajay, Hurtado Jonathan, Dueker Katharina, Capozzola Tazio, Nedellec Rebecca, Ozorowski Gabriel, Lewis Mark M, Falcone Samantha, Carfi Andrea, Himansu Sunny, Shapiro Lawrence, Crispin Max, Hahn Beatrice H, Briney Bryan, Irvine Darrell J, Burton Dennis R, Ward Andrew B, Batista Facundo D, Kwong Peter D, Shaw George M, Andrabi Raiees

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization.

在恒河猴 V2 顶端种系抗体小鼠模型中,单次注射免疫后即可快速获得 HIV-1 中和广度

Ghosh Amrit Raj, Habib Rumi, Mishra Nitesh, Roark Ryan S, Akauliya Madhav, Albowaidey Ali A, Allen Joel D, Amereh Khaled, Avillion Gabriel, Bottermann Maria, Liang Bo, Chaudhary Namit, Callaghan Sean, Dye Jonathan, Li Xuduo, Ellis-Pugh Jordan R, Chowdhury Rohan Roy, James Nicole E, Liu Xiaotie, Maiorino Laura, Maldonado Paula, Nedellec Rebecca, Oberoi Prabhgun, Sowers Kirsten J, Park Younghoon, Prum Thavaleak, Rodriguez Linette, Ssozi Maria, Torres Jon, Walsh Agnes A, Warner John E, Weldon Stephanie R, Xu Liling, Wiehe Kevin, Crispin Max, Ward Andrew B, Nair Usha, Hahn Beatrice H, Burton Dennis R, Shapiro Lawrence, Kwong Peter D, Irvine Darrell J, Andrabi Raiees, Shaw George M, Batista Facundo D