日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Unhooking the Hook: Optimization of the Aurora A Targeting PROTAC JB170 to CCT400028, an In Vitro Degrader Chemical Probe

解开钩子:优化 Aurora A 靶向 PROTAC JB170 至 CCT400028,一种体外降解化学探针

O'Hanlon, Jack A; Gutsche, Katrin; Müller, Juliane Elisabeth; Ranjan Prusty, Nihar; Mirza, Amin; Roumeliotis, Theodoros I; Yang, Hengzhang; Stubbs, Mark; Hallett, Stephen T; Eing, Lorenz; McAndrew, Peter Craig; Choudhary, Jyoti Sharma; Le Bihan, Yann-Vaï; Caldwell, John; van Montfort, Rob L M; Workman, Paul; Wolf, Elmar; Newton, Gary K; Evans, Lindsay E

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells.

人类 DEAH 盒解旋酶 8 调节 HSF1 介导的应激反应和肿瘤细胞中与癌症相关的 pre-mRNA 剪接。

Tall Jennifer R, Te Poele Robert, Vasile Alexandra, Ramagiri Pradeep, Campbell James, Davies Caitlin R, Powers Marissa V, Roe Toby, Sankaran Deivendran, Wang Hannah, Mitsopoulos Konstantinos, Al-Lazikani Bissan, van Montfort Rob L M, de Billy Emmanuel, Workman Paul, Clarke Paul A

Intrinsic tumor factors and extrinsic environmental and social exposures contribute to endometrial cancer recurrence patterns

肿瘤内在因素以及外部环境和社会因素均会导致子宫内膜癌复发。

Bosquet, Jesus Gonzalez; Osazuwa-Peters, Oyomoare; Wagner, Vincent M; Polio, Andrew; Hoyd, Rebecca; Tarhini, Ahmad A; Cosgrove, Casey M; Huang, Marilyn S; Corr, Bradley R; Leiser, Aliza L; Salhia, Bodour; Darcy, Kathleen; Dood, Rob L; Dockery, Lauren E; Cavnar, Michael J; Landrum, Lisa; Chambers, Laura; Tan, Aik Choon; Jin, Ning; Rounbehler, Robert J; Churchman, Michelle L; Spakowicz, Dan

Training, Validating, and Testing Machine Learning Prediction Models for Endometrial Cancer Recurrence

训练、验证和测试用于预测子宫内膜癌复发的机器学习模型

Gonzalez Bosquet, Jesus; Polio, Andrew; George, Erin; Tarhini, Ahmad A; Cosgrove, Casey M; Huang, Marilyn S; Corr, Bradley; Leiser, Aliza L; Salhia, Bodour; Darcy, Kathleen; Tarney, Christopher M; Dood, Rob L; Dockery, Lauren E; Edge, Stephen B; Cavnar, Michael J; Landrum, Lisa; Rounbehler, Rob J; Churchman, Michelle; Wagner, Vincent M

Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening.

通过片段筛选发现TRF1:TIN2蛋白相互作用的首创抑制剂。

Casale Giacomo, Liu Manjuan, Le Bihan Yann-Vaï, Inian Oviya, Stammers Ellie, Caldwell John, van Montfort Rob L M, Collins Ian, Guettler Sebastian

Hydrology for impact: building partnerships, blending knowledge and bracing for climate change

水文影响:构建伙伴关系、融合知识、应对气候变化

Orr, Harriet G; Hall, Caitlyn A; Rhodes, Vicki; Wilby, Rob L; Peat, Katy L; Fowler, Hayley J

Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD

在DPYD公司内外发现与严重氟嘧啶类药物相关毒性相关的新型种系遗传变异

Knikman, Jonathan E; Zhai, Qinglian; Lunenburg, Carin A T C; Henricks, Linda M; Böhringer, Stefan; van der Lee, Maaike; de Man, Femke M; Offer, Steven M; Shrestha, Shikshya; Creemers, Geert-Jan; Baars, Arnold; Dezentjé, Vincent O; Imholz, Alexander L T; Jeurissen, Frank J F; Portielje, Johanna E A; Jansen, Rob L H; Hamberg, Paul; Droogendijk, Helga J; Koopman, Miriam; Nieboer, Peter; van de Poel, Marlène H W; Mandigers, Caroline M P W; van Schaik, Ron H N; Gelderblom, Hans; Mathijssen, Ron H J; Schellens, Jan H M; Cats, Annemieke; Guchelaar, Henk-Jan; Swen, Jesse J

Characterization of degradation kinetics of additively manufactured PLGA under variable mechanical loading paradigms

增材制造PLGA在不同机械载荷条件下的降解动力学表征

Smith, Anna N; Ulsh, Joseph B; Gupta, Richa; Tang, My My; Peredo, Ana P; Teinturier, Tim D; Mauck, Rob L; Gullbrand, Sarah; Hast, Michael W

Specific radiation damage to halogenated inhibitors and ligands in protein-ligand crystal structures

蛋白质-配体晶体结构中卤代抑制剂和配体的特定辐射损伤

Rodrigues, Matthew J; Cabry, Marc; Collie, Gavin; Carter, Michael; McAndrew, Craig; Owen, Robin L; Bellenie, Benjamin R; Le Bihan, Yann-Vaï; van Montfort, Rob L M

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones

通过优化三环喹啉酮发现一种用于抑制BCL6的体内化学探针

Harnden, Alice C; Davis, Owen A; Box, Gary M; Hayes, Angela; Johnson, Louise D; Henley, Alan T; de Haven Brandon, Alexis K; Valenti, Melanie; Cheung, Kwai-Ming J; Brennan, Alfie; Huckvale, Rosemary; Pierrat, Olivier A; Talbot, Rachel; Bright, Michael D; Akpinar, Hafize Aysin; Miller, Daniel S J; Tarantino, Dalia; Gowan, Sharon; de Klerk, Selby; McAndrew, Peter Craig; Le Bihan, Yann-Vaï; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen