日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

ALS 相关蛋白 TDP-43 维持运动神经元生长和修复介质 STMN2 的水平

Joseph R Klim, Luis A Williams, Francesco Limone, Irune Guerra San Juan, Brandi N Davis-Dusenbery, Daniel A Mordes, Aaron Burberry, Michael J Steinbaugh, Kanchana K Gamage, Rory Kirchner, Rob Moccia, Seth H Cassel, Kuchuan Chen, Brian J Wainger, Clifford J Woolf, Kevin Eggan

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

PF-06409577激活肝脏AMPK可纠正啮齿动物和灵长类动物临床前模型中的非酒精性脂肪性肝病并降低胆固醇

Ryan M Esquejo ,Christopher T Salatto ,Jake Delmore ,Bina Albuquerque ,Allan Reyes ,Yuji Shi ,Rob Moccia ,Emily Cokorinos ,Matthew Peloquin ,Mara Monetti ,Jason Barricklow ,Eliza Bollinger ,Brennan K Smith ,Emily A Day ,Chuong Nguyen ,Kieran F Geoghegan ,John M Kreeger ,Alan Opsahl ,Jessica Ward ,Amit S Kalgutkar ,David Tess ,Lynne Butler ,Norimitsu Shirai ,Timothy F Osborne ,Gregory R Steinberg ,Morris J Birnbaum ,Kimberly O Cameron ,Russell A Miller

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

二肽重复蛋白激活 C9ORF72-ALS/FTLD 患者的热休克反应

Daniel A Mordes, Mercedes Prudencio, Lindsey D Goodman, Joseph R Klim, Rob Moccia, Francesco Limone, Olli Pietilainen, Kaitavjeet Chowdhary, Dennis W Dickson, Rosa Rademakers, Nancy M Bonini, Leonard Petrucelli, Kevin Eggan0

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease

C9ORF72 小鼠直系同源物的功能丧失突变导致致命的自身免疫性疾病

Aaron Burberry, Naoki Suzuki, Jin-Yuan Wang, Rob Moccia, Daniel A Mordes, Morag H Stewart, Satomi Suzuki-Uematsu, Sulagna Ghosh, Ajay Singh, Florian T Merkle, Kathryn Koszka, Quan-Zhen Li, Leonard Zon, Derrick J Rossi, Jennifer J Trowbridge, Luigi D Notarangelo, Kevin Eggan

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1

通过对突变 SOD1 进行基因校正,确定人类 ALS 运动神经元中被破坏的通路

Evangelos Kiskinis, Jackson Sandoe, Luis A Williams, Gabriella L Boulting, Rob Moccia, Brian J Wainger, Steve Han, Theodore Peng, Sebastian Thams, Shravani Mikkilineni, Cassidy Mellin, Florian T Merkle, Brandi N Davis-Dusenbery, Michael Ziller, Derek Oakley, Justin Ichida, Stefania Di Costanzo, Nick

The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD

小鼠 C9ORF72 直系同源物在已知在 ALS 和 FTD 中退化的神经元中富集

Naoki Suzuki, Asif M Maroof, Florian T Merkle, Kathryn Koszka, Atsushi Intoh, Ian Armstrong, Rob Moccia, Brandi N Davis-Dusenbery, Kevin Eggan