Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies
从已批准药物库的高通量筛选中鉴定哈尔明和β-咔啉类似物;分析其作为DYRK1A和单胺氧化酶A差异性抑制剂的特性,并用于体外和体内抗癌研究。
期刊:European Journal of Pharmaceutical Sciences
影响因子:4.3
doi:10.1016/j.ejps.2021.105821
Michael Tarpley ,Helen O Oladapo ,Dillon Strepay ,Thomas B Caligan ,Lhoucine Chdid ,Hassan Shehata ,Jose R Roques ,Rhashad Thomas ,Christopher P Laudeman ,Rob U Onyenwoke ,David B Darr ,Kevin P Williams