日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers

靶向β-catenin:PROTACs和精准降解剂治疗Wnt驱动型癌症

Trapani, Jonathan; Caroland, Kailey P; Ahmed, Yashi; Robbins, David J; Weiss, Vivian L; Lee, Ethan

The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling.

TRIP12 E3 连接酶诱导 SWI/SNF 成分 BRG1-β-catenin 相互作用,从而促进 Wnt 信号传导

Kassel Sara, Yuan Kai, Bunnag Nawat, Neitzel Leif R, Lu Wenhui, Schwarzkopf Anna, Maines Benjamin, Loberg Matthew A, Xu George, Adams Amber, McCray Andrew D, Cho Alex, Rockouski Mary, Orton Gemma, Goldsmith Lily, Aronno Md Mubtaseem Ahnaf, Spencer Zachary T, Khan Omar M, Ye Fei, Williams Charles, Lebensohn Andres M, Rohatgi Rajat, Wang Xiaofeng, Weiss Vivian L, Hong Charles C, Kettenbach Arminja N, Robbins David J, Ahmed Yashi, Lee Ethan

Wnt signaling inhibits casein kinase 1α activity by modulating its interaction with protein phosphatase 2A.

Wnt信号通过调节酪蛋白激酶1α与蛋白磷酸酶2A的相互作用来抑制酪蛋白激酶1α的活性。

Shen Chen, Lu Wenhui, Merugu Siva B, Bharti Aradhana, Afify Said M, Schnitkey Lauren, Wynn Daniel T, Yang Fan, Rohwetter Thomas M, Nayak Anmada, Bunnag Nawat, Cywiak Carolina, Tang Hsin-Yao, Harris Brent T, Albanese Christopher, Ihemelandu Chukwuemeka, Cobb Melanie H, Kettenbach Arminja, Lee Ethan, Ahmed Yashi, Robbins David J

Wnt signalosomes: What we know that we do not know

Wnt信号体:我们已知但未知的部分

Hartmann, Heather; Siddiqui, Ghalia Saad; Bryant, Jamal; Robbins, David J; Weiss, Vivian L; Ahmed, Yashi; Lee, Ethan

RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription

RAC1通过GLI介导的转录调控Shh-髓母细胞瘤的生长

Jangde, Nitish; Lee, Mi Hye; Ruiz, Luz; Egan, Isabelle; Jermakowicz, Anna M; Wynn, Daniel; Goka, Erik; Lippman, Marc; Robbins, David J; Ayad, Nagi G

Exploring the role of casein kinase 1α splice variants across cancer cell lines.

探索酪蛋白激酶 1α 剪接变体在癌细胞系中的作用

Meléndez Ricardo A, Wynn Daniel T, Merugu Siva Bharath, Singh Prerna, Kaplan Kenton P, Robbins David J

Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer

多蛋白GLI转录复合物作为癌症治疗靶点

Yang, Fan; Wynn, Daniel T; Shen, Chen; Ayad, Nagi G; Robbins, David J

A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma

CK1α激活剂可穿透血脑屏障,并对耐药性转移性髓母细胞瘤显示出疗效

Rodriguez-Blanco, Jezabel; Li, Bin; Long, Jun; Shen, Chen; Yang, Fan; Orton, Darren; Collins, Sara; Kasahara, Noriyuki; Ayad, Nagi G; McCrea, Heather J; Roussel, Martine F; Weiss, William A; Capobianco, Anthony J; Robbins, David J

Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells

单细胞分析证实LRP6在APC缺陷细胞的Wnt信号通路中起关键作用

Cabel, Carly R; Alizadeh, Elaheh; Robbins, David J; Ahmed, Yashi; Lee, Ethan; Thorne, Curtis A

Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner

产前砷暴露会以性别依赖的方式改变胎盘中多种表观遗传调控因子的表达。

Winterbottom, Emily F; Moroishi, Yuka; Halchenko, Yuliya; Armstrong, David A; Beach, Paul J; Nguyen, Quang P; Capobianco, Anthony J; Ayad, Nagi G; Marsit, Carmen J; Li, Zhigang; Karagas, Margaret R; Robbins, David J