日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advances in BRET probes for intracellular target engagement studies

用于细胞内靶标结合研究的BRET探针的进展

Capener, Jacob L; Schwalm, Martin P; Vasta, James D; Michaud, Ani; Teske, Kelly A; Marsiglia, William M; Huber, Kilian V M; Dar, Arvin C; Knapp, Stefan; Axtman, Alison D; Robers, Matthew B

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.

一种用于测量细胞中 PRMT5 复合物非竞争性结合的 BRET 生物传感器。

Rothweiler Elisabeth M, Michaud Ani, Stefaniak Jakub, Singh Usha, Mikulsky Brynwood B, Vasta James D, Beck Michael T, Wilkinson Jennifer, Ward Jennifer A, Rogers Catherine M, Balıkçı Esra, Tranberg-Jensen Jeppe, Hansen Jesper S, Loppnau Peter, Whitty Adrian, Brennan Paul E, Tonge Peter J, Robers Matthew B, Huber Kilian V M

Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation.

泛素-蛋白酶体系统 (UPS) 通路抑制剂的功能表征,作为 CRBN 和 VHL 介导的靶向蛋白质降解的工具化合物

Schwalm Martin P, Menge Amelie, Elson Lewis, Greco Francesco A, Robers Matthew B, Müller Susanne, Knapp Stefan

Cellular Selectivity Analyses Reveal Distinguishing Profiles for Type II Kinase Inhibitors

细胞选择性分析揭示了II型激酶抑制剂的独特特征

Binder, Matthew J; Bashore, Frances M; Hoffman, Kaitlin K Dunn; Daamgard, Cameron; Slater, Michael R; Drewry, David H; Robers, Matthew B; Axtman, Alison D

Reversible male contraception by targeted inhibition of serine/threonine kinase 33

通过靶向抑制丝氨酸/苏氨酸激酶33实现可逆性男性避孕

Ku, Angela F; Sharma, Kiran L; Ta, Hai Minh; Sutton, Courtney M; Bohren, Kurt M; Wang, Yong; Chamakuri, Srinivas; Chen, Ruihong; Hakenjos, John M; Jimmidi, Ravikumar; Kent, Katarzyna; Li, Feng; Li, Jian-Yuan; Ma, Lang; Madasu, Chandrashekhar; Palaniappan, Murugesan; Palmer, Stephen S; Qin, Xuan; Robers, Matthew B; Sankaran, Banumathi; Tan, Zhi; Vasquez, Yasmin M; Wang, Jian; Wilkinson, Jennifer; Yu, Zhifeng; Ye, Qiuji; Young, Damian W; Teng, Mingxing; Kim, Choel; Matzuk, Martin M

tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis

tracerDB:一个用于靶标结合分析的众包荧光示踪剂数据库

Dopfer, Johannes; Vasta, James D; Müller, Susanne; Knapp, Stefan; Robers, Matthew B; Schwalm, Martin P

Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology.

利用DNA编码化学技术发现高效且对ALK2/ALK1具有选择性的激酶抑制剂

Jimmidi Ravikumar, Monsivais Diana, Ta Hai Minh, Sharma Kiran L, Bohren Kurt M, Chamakuri Srinivas, Liao Zian, Li Feng, Hakenjos John M, Li Jian-Yuan, Mishina Yuji, Pan Haichun, Qin Xuan, Robers Matthew B, Sankaran Banumathi, Tan Zhi, Tang Suni, Vasquez Yasmin M, Wilkinson Jennifer, Young Damian W, Palmer Stephen S, MacKenzie Kevin R, Kim Choel, Matzuk Martin M

Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants

开发用于功能获得性变异体的SYK NanoBRET细胞靶标结合分析方法

Capener, Jacob L; Vasta, James D; Katis, Vittorio L; Michaud, Ani; Beck, Michael T; Daglish, Sabrina C D; Cohen-Kedar, Sarit; Barda, Efrat Shaham; Howell, Stefanie; Dotan, Iris; Robers, Matthew B; Axtman, Alison D; Bashore, Frances M

Resistance to kinase inhibition through shortened target engagement

通过缩短靶点结合时间而产生的激酶抑制耐药性

Rangwala, Aziz M; Berger, Benedict-Tilman; Robers, Matthew B; Knapp, Stefan; Seeliger, Markus A

Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Abl激酶突变导致药物结合动力学改变,提示了一种新的伊马替尼耐药机制。

Lyczek, Agatha; Berger, Benedict-Tilman; Rangwala, Aziz M; Paung, YiTing; Tom, Jessica; Philipose, Hannah; Guo, Jiaye; Albanese, Steven K; Robers, Matthew B; Knapp, Stefan; Chodera, John D; Seeliger, Markus A