日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity

POLE 和 POLD1 突变在检查点阻断依赖性抗肿瘤免疫中的功能概况

Xiaoxiao Ma, Nadeem Riaz, Robert M Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W R Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y Sabio, Richa Verma, Raghvendra M Sriv

Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

BRCA1 和 BRCA2 突变对肿瘤微环境和检查点阻断免疫疗法反应有不同的影响

Robert M Samstein #, Chirag Krishna #, Xiaoxiao Ma #, Xin Pei, Ken-Wing Lee, Vladimir Makarov, Fengshen Kuo, Jonathan Chung, Raghvendra M Srivastava, Tanaya A Purohit, Douglas R Hoen, Rajarsi Mandal, Jeremy Setton, Wei Wu, Rachna Shah, Besnik Qeriqi, Qing Chang, Sviatoslav Kendall, Lior Braunstein, 

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

源自基因融合的免疫原性新抗原可刺激T细胞反应。

Wei Yang ,Ken-Wing Lee ,Raghvendra M Srivastava ,Fengshen Kuo ,Chirag Krishna ,Diego Chowell ,Vladimir Makarov ,Douglas Hoen ,Martin G Dalin ,Leonard Wexler ,Ronald Ghossein ,Nora Katabi ,Zaineb Nadeem ,Marc A Cohen ,S Ken Tian ,Nicolas Robine ,Kanika Arora ,Heather Geiger ,Phaedra Agius ,Nancy Bouvier ,Kety Huberman ,Katelynd Vanness ,Jonathan J Havel ,Jennifer S Sims ,Robert M Samstein ,Rajarsi Mandal ,Justin Tepe ,Ian Ganly ,Alan L Ho ,Nadeem Riaz ,Richard J Wong ,Neerav Shukla ,Timothy A Chan ,Luc G T Morris

In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors

用特定因子进行原位疫苗接种可克服远处肿瘤中的 T 细胞耗竭

Danny N Khalil, Nathan Suek, Luis Felipe Campesato, Sadna Budhu, David Redmond, Robert M Samstein, Chirag Krishna, Katherine S Panageas, Marinela Capanu, Sean Houghton, Daniel Hirschhorn, Roberta Zappasodi, Rachel Giese, Billel Gasmi, Michael Schneider, Aditi Gupta, James J Harding, John Alec Moral,

An Antitumor Immune Response Is Evoked by Partial-Volume Single-Dose Radiation in 2 Murine Models

部分体积单剂量辐射在 2 种小鼠模型中引发抗肿瘤免疫反应

Ela Markovsky, Sadna Budhu, Robert M Samstein, Hongyan Li, James Russell, Zhigang Zhang, Esther Drill, Chloe Bodden, Qing Chen, Simon N Powell, Taha Merghoub, Jedd D Wolchok, John Humm, Joseph O Deasy, Adriana Haimovitz-Friedman

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

炎症诱导的调节性 T 细胞中转录因子 Foxp3 结合染色质的抑制

Aaron Arvey #, Joris van der Veeken #, Robert M Samstein #, Yongqiang Feng, John A Stamatoyannopoulos, Alexander Y Rudensky

Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict

胎盘哺乳动物胸腺外产生调节性 T 细胞可减轻母胎冲突

Robert M Samstein, Steven Z Josefowicz, Aaron Arvey, Piper M Treuting, Alexander Y Rudensky

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

Foxp3 利用预先存在的增强子景观来调节 T 细胞谱系

Robert M Samstein, Aaron Arvey, Steven Z Josefowicz, Xiao Peng, Alex Reynolds, Richard Sandstrom, Shane Neph, Peter Sabo, Jeong M Kim, Will Liao, Ming O Li, Christina Leslie, John A Stamatoyannopoulos, Alexander Y Rudensky

Transcription factor Foxp3 and its protein partners form a complex regulatory network

转录因子 Foxp3 及其蛋白质伙伴形成复杂的调控网络

Dipayan Rudra, Paul deRoos, Ashutosh Chaudhry, Rachel E Niec, Aaron Arvey, Robert M Samstein, Christina Leslie, Scott A Shaffer, David R Goodlett, Alexander Y Rudensky