Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations
对携带 H3K27M 突变的弥漫性中线胶质瘤长期生存者的临床、基因组和表观基因组分析揭示了一类具有 MAPK 通路改变的独特肿瘤群体。
期刊:Acta Neuropathologica
影响因子:9.3
doi:10.1007/s00401-023-02640-7
Roberts, Holly J; Ji, Sunjong; Picca, Alberto; Sanson, Marc; Garcia, Mekka; Snuderl, Matija; Schüller, Ulrich; Picart, Thiébaud; Ducray, François; Green, Adam L; Nakano, Yoshiko; Sturm, Dominik; Abdullaev, Zied; Aldape, Kenneth; Dang, Derek; Kumar-Sinha, Chandan; Wu, Yi-Mi; Robinson, Dan; Vo, Josh N; Chinnaiyan, Arul M; Cartaxo, Rodrigo; Upadhyaya, Santhosh A; Mody, Rajen; Chiang, Jason; Baker, Suzanne; Solomon, David; Venneti, Sriram; Pratt, Drew; Waszak, Sebastian M; Koschmann, Carl
肿瘤
表观遗传
肿瘤免疫
信号转导
MAPK/ERK
胶质瘤
