日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells

SCD1抑制剂阿莫西林与瑞戈非尼和二甲双胍相互作用,可杀死肿瘤细胞。

Booth, Michael R; Booth, Laurence; Roberts, Jane L; Kirkwood, John M; Dent, Paul

Targeting SUMOylation promotes cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma.

靶向 SUMO 化可促进 cBAF 复合物的稳定,并破坏滑膜肉瘤中的 SS18::SSX 转录组。

Floros Konstantinos V, Fairchild Carter K Jr, Li Jinxiu, Zhang Kun, Roberts Jane L, Kurupi Richard, Paudel Durga, Xing Yanli, Hu Bin, Kraskauskiene Vita, Hosseini Nayyerehalsadat, Shen Shanwei, Inge Melissa M, Smith-Fry Kyllie, Li Li, Sotiriou Afroditi, Dalton Krista M, Jose Asha, Abdelfadiel Elsamani I, Hill Ronald D, Slaughter Jamie M, Shende Mayuri, Lorenz Madelyn R, Tanaka Noritaka, Kajino Taisuke, Nelson Mary L, Hinojosa Mandy R, Kehinde Victor A, Belvin Benjamin R, Sugiokto Febri G, Lai Zhao, Dimopoulos Alexandros C, Boikos Sosipatros A, Stamatouli Angeliki M, Lewis Janina P, Manjili Masoud H, Ebi Hiromichi, Valerie Kristoffer, Li Renfeng, Poklepovic Andrew, Koblinski Jennifer E, Siggers Trevor, Banito Ana, Dozmorov Mikhail G, Jones Kevin B, Radhakrishnan Senthil K, Faber Anthony C

The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo

SCD1抑制剂阿拉姆醇与瑞戈非尼相互作用,可在体外和体内杀死胃肠道肿瘤细胞。

Booth, Laurence; Booth, Michael R; Roberts, Jane L; Yue, Yang; Kinsey, Emily; Poklepovic, Andrew; Boone, David; Cowhart, L Ashley; Baharaff, Allen; Dent, Paul

Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype

小鼠慢性炎症和神经性疼痛模型中自愿跑轮能力的缺陷:性别和基因型的影响

Contreras, Katherine M; Caillaud, Martial; Neddenriep, Bradley; Bagdas, Deniz; Roberts, Jane L; Ulker, Esad; White, Alyssa B; Aboulhosn, Raneem; Toma, Wisam; Khalefa, Tala; Adel, Ahd; Mann, Jared A; Damaj, M Imad

The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib

细胞信号传导在自噬和凋亡之间的相互作用中,调控肿瘤细胞对索拉非尼和奈拉替尼的存活反应中的作用

Booth, Laurence A; Roberts, Jane L; Dent, Paul

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells.

奈拉替尼抑制 Hippo/YAP 信号传导,降低突变 K-RAS 表达,并杀死胰腺癌和血癌细胞

Dent Paul, Booth Laurence, Roberts Jane L, Liu Junchen, Poklepovic Andrew, Lalani Alshad S, Tuveson David, Martinez Jennifer, Hancock John F

Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition.

Palbociclib 可增强 Neratinib 对肿瘤细胞的杀伤作用,而 HDAC 抑制剂可进一步增强这种作用

Booth Laurence, Roberts Jane L, Rais Rumeesa, Cutler Richard E Jr, Diala Irmina, Lalani Alshad S, Poklepovic Andrew, Dent Paul

Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, Gα(q) and Gα(11) and kill uveal melanoma cells.

奈拉替尼和恩替诺特联合使用可快速降低 K-RAS、N-RAS、Gα(q) 和 Gα(11) 的表达,并杀死葡萄膜黑色素瘤细胞

Booth Laurence, Roberts Jane L, Sander Cindy, Lalani Alshad S, Kirkwood John M, Hancock John F, Poklepovic Andrew, Dent Paul

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo

更正:HDAC抑制剂可增强奈拉替尼的活性,并且当与奈拉替尼联合使用时,可增强抗PD-1免疫调节抗体在体内的作用。

Booth, Laurence; Roberts, Jane L; Poklepovic, Andrew; Avogadri-Connors, Francesca; Cutler, Richard E; Lalani, Alshad S; Dent, Paul

The levels of mutant K-RAS and mutant N-RAS are rapidly reduced in a Beclin1 / ATG5 -dependent fashion by the irreversible ERBB1/2/4 inhibitor neratinib

不可逆的ERBB1/2/4抑制剂奈拉替尼以Beclin1/ATG5依赖的方式迅速降低突变型K-RAS和突变型N-RAS的水平。

Booth, Laurence; Roberts, Jane L; Poklepovic, Andrew; Kirkwood, John; Sander, Cindy; Avogadri-Connors, Francesca; Cutler, Richard E Jr; Lalani, Alshad S; Dent, Paul