Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer
发现STX-721,一种共价、高效且高度突变选择性的EGFR/HER2 20号外显子插入抑制剂,用于治疗非小细胞肺癌
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c02377
Milgram, Benjamin C; Borrelli, Deanna R; Brooijmans, Natasja; Henderson, Jack A; Hilbert, Brendan J; Huff, Michael R; Ito, Takahiro; Jackson, Erica L; Jonsson, Philip; Ladd, Brendon; O'Hearn, Erin L; Pagliarini, Raymond A; Roberts, Simon A; Ronseaux, Sébastien; Stuart, Darrin D; Wang, Weixue; Guzman-Perez, Angel