日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson's disease brain as revealed by multicolor STED microscopy

多色 STED 显微镜显示帕金森病患者大脑中 α-突触核蛋白蛋白质形式的亚细胞排列

Tim E Moors, Christina A Maat, Daniel Niedieker, Daniel Mona, Dennis Petersen, Evelien Timmermans-Huisman, Jeroen Kole, Samir F El-Mashtoly, Liz Spycher, Wagner Zago, Robin Barbour, Olaf Mundigl, Klaus Kaluza, Sylwia Huber, Melanie N Hug, Thomas Kremer, Mirko Ritter, Sebastian Dziadek, Jeroen J G Ge

Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

针对淀粉样变性形式的转甲状腺素蛋白的新型构象特异性单克隆抗体

Jeffrey N Higaki, Avi Chakrabartty, Natalie J Galant, Kevin C Hadley, Bradley Hammerson, Tarlochan Nijjar, Ronald Torres, Jose R Tapia, Joshua Salmans, Robin Barbour, Stephen J Tam, Ken Flanagan, Wagner Zago, Gene G Kinney

Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models

通过免疫疗法减少 C 端截短的 α-突触核蛋白可减轻帕金森病样模型中的神经退行性和增殖

Dora Games, Elvira Valera, Brian Spencer, Edward Rockenstein, Michael Mante, Anthony Adame, Christina Patrick, Kiren Ubhi, Silke Nuber, Patricia Sacayon, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Eliezer Masliah

Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein

路易体病 α-突触核蛋白转基因模型中的轴突病变与 C 端截短的 α-突触核蛋白的大量积累有关

Dora Games, Peter Seubert, Edward Rockenstein, Christina Patrick, Margarita Trejo, Kiren Ubhi, Benjamin Ettle, Majid Ghassemiam, Robin Barbour, Dale Schenk, Silke Nuber, Eliezer Masliah

AL amyloid imaging and therapy with a monoclonal antibody to a cryptic epitope on amyloid fibrils

AL 淀粉样蛋白成像和使用针对淀粉样蛋白纤维上隐蔽表位的单克隆抗体进行治疗

Jonathan S Wall, Stephen J Kennel, Angela Williams, Tina Richey, Alan Stuckey, Ying Huang, Sallie Macy, Robert Donnell, Robin Barbour, Peter Seubert, Dale Schenk

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

被动免疫可减少路易体病 α-突触核蛋白转基因模型中的行为和神经病理学缺陷

Eliezer Masliah, Edward Rockenstein, Michael Mante, Leslie Crews, Brian Spencer, Anthony Adame, Christina Patrick, Margarita Trejo, Kiren Ubhi, Troy T Rohn, Sarah Mueller-Steiner, Peter Seubert, Robin Barbour, Lisa McConlogue, Manuel Buttini, Dora Games, Dale Schenk

Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease

阿尔茨海默病小鼠模型中与淀粉样β蛋白相关行为缺陷急性逆转相关的抗体的结构相关性

Guriqbal S Basi, Hadar Feinberg, Farshid Oshidari, John Anderson, Robin Barbour, Jeanne Baker, Thomas A Comery, Linnea Diep, Davinder Gill, Kelly Johnson-Wood, Amita Goel, Katerina Grantcharova, Mike Lee, Jingzhi Li, Anthony Partridge, Irene Griswold-Prenner, Nicolas Piot, Don Walker, Angela Widom,