日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia

PNA5 是一种新型 Mas 受体激动剂,可改善血管性认知障碍和痴呆症小鼠模型中的神经血管和血脑屏障功能

Christina Hoyer-Kimura, Meredith Hay, John P Konhilas, Helena W Morrison, Methawasin Methajit, Joshua Strom, Robin Polt, Victoria Salcedo, Joshua P Fricks, Anjna Kalya, Paulo W Pires

Glycosylated Ang-(1-7) MasR Agonist Peptide Poly Lactic-co-Glycolic Acid (PLGA) Nanoparticles and Microparticles in Cognitive Impairment: Design, Particle Preparation, Physicochemical Characterization, and In Vitro Release

糖基化 Ang-(1-7) MasR 激动剂肽聚乳酸-乙醇酸共聚物 (PLGA) 纳米颗粒和微粒在认知障碍中的应用:设计、颗粒制备、物理化学表征和体外释放

David Encinas-Basurto, John P Konhilas, Robin Polt, Meredith Hay, Heidi M Mansour

Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1-7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers

先进喷雾干燥和共喷雾干燥的血管紧张素 (1-7) 肽和 PNA5 与海藻糖作为微粒/纳米颗粒的合成、物理化学表征、体外 2D/3D 人体细胞培养和体外气溶胶分散性能,用于作为干粉吸入器进行靶向呼吸输送

Wafaa Alabsi, Maria F Acosta, Fahad A Al-Obeidi, Meredith Hay, Robin Polt, Heidi M Mansour

Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin for Respiratory Delivery: Physicochemical Characterization, In Vitro Aerosol Dispersion, and Cellular Studies

用于呼吸输送的乳吗啡的有机溶液高级喷雾干燥微粒/纳米颗粒干粉:物理化学特性、体外气溶胶分散和细胞研究

Wafaa Alabsi, Fahad A Al-Obeidi, Robin Polt, Heidi M Mansour

Sphingosine-1-phosphate receptor-independent lung endothelial cell barrier disruption induced by FTY720 regioisomers

FTY720 区域异构体诱导的鞘氨醇-1-磷酸受体非依赖性肺内皮细胞屏障破坏

Sara M Camp, Alexander Marciniak, Eddie T Chiang, Alexander N Garcia, Robert Bittman, Robin Polt, Ruth G Perez, Steven M Dudek, Joe G N Garcia

The Delta-Specific Opioid Glycopeptide BBI-11008: CNS Penetration and Behavioral Analysis in a Preclinical Model of Levodopa-Induced Dyskinesia

δ 特异性阿片类糖肽 BBI-11008:左旋多巴诱发的运动障碍临床前模型中的中枢神经系统渗透和行为分析

Mitchell J Bartlett, Omar S Mabrouk, Lajos Szabò, Andrew J Flores, Kate L Parent, Jean M Bidlack, Michael L Heien, Robert T Kennedy, Robin Polt, Scott J Sherman, Torsten Falk

Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration

混合作用 delta 选择性阿片受体激动剂 BBI-11008 的行为药理学:对急性、炎症和神经性疼痛、呼吸和药物自我给药的研究

Glenn W Stevenson, Denise Giuvelis, James Cormier, Katherine Cone, Phillip Atherton, Rebecca Krivitsky, Emily Warner, Brooke St Laurent, Julio Dutra, Jean M Bidlack, Lajos Szabò, Robin Polt, Edward J Bilsky

A Novel Angiotensin-(1-7) Glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation-Related Memory Dysfunction

一种新型血管紧张素-(1-7)糖基化 Mas 受体激动剂,用于治疗血管性认知障碍和炎症相关记忆功能障碍

Meredith Hay, Robin Polt, Michael L Heien, Todd W Vanderah, Tally M Largent-Milnes, Kathleen Rodgers, Torsten Falk, Mitchell J Bartlett, Kristian P Doyle, John P Konhilas

The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia

阿片类糖肽 MMP-2200 与 NMDA 受体拮抗剂的组合可减轻 l-DOPA 引起的运动障碍,而 MMP-2200 本身可减轻多巴胺受体 2 样激动剂引起的运动障碍

Andrew J Flores, Mitchell J Bartlett, Brandon K Root, Kate L Parent, Michael L Heien, Frank Porreca, Robin Polt, Scott J Sherman, Torsten Falk

The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

混合作用的 delta/mu 阿片类激动剂 MMP-2200 不会产生条件性位置偏好,但确实会在大鼠体内维持药物自我给药,并诱导耐受性和依赖性的体外标志物

Glenn W Stevenson, Amy Luginbuhl, Catherine Dunbar, Justin LaVigne, Julio Dutra, Phillip Atherton, Brooke Bell, Katherine Cone, Denise Giuvelis, Robin Polt, John M Streicher, Edward J Bilsky