Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension
治疗性Fc融合因子VIII在中性pH条件下与新生儿Fc受体结合,导致半衰期延长效果不佳。
期刊:Haematologica
影响因子:8.2
doi:10.3324/haematol.2024.286536.
Alejandra Reyes-Ruiz,Sandrine Delignat,Aishwarya Sudam Bhale,Victoria Daventure,Robin V Lacombe,Leslie Dourthe,Olivier Christophe,Sune Justesen,Krishnan Venkataraman,Jordan D Dimitrov,Sebastien Lacroix-Desmazes