Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER(+) Breast Cancer

在PTEN缺陷型ER(+)乳腺癌中，同时抑制磷脂酰肌醇3-激酶的p110α和p110β两种亚型是维持治疗效果所必需的。