日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CD4(+) T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy.

CD4(+) T 细胞介导 BCMA CAR-T 细胞治疗后 CAR-T 细胞相关的免疫相关不良事件。

Ho Matthew, Paruzzo Luca, Noll Julia Han, Stella Federico, Devi Pooja, Ndeupen Sonia, Day Yael A, Chen Gregory M, Cohen Ivan J, Ramirez-Fernandez Angel, Waxman Adam, Kapur Shivani, Chen Fang, Xu Rong, Huff Andrew, Jarocha Danuta, Patel Vrutti, Bochi-Layec Audrey C, Ramasubramanian Ranjani, Liu Shan, Bouvier Riemke, de Souza Vitor B, Patel Heta, Li Ziyu, Carturan Alberto, Michener Peter, Hopkins Caitlin R, Koucky Owen, Minehart Janna, Dimitri Alex, Nabar Neel R, Hasanali Zainul S, Ciccarelli Bryan T, Hung Putzer, Williams Erik, Bartoszek Robert, Lavorando Maya, Mohan Suyash, Gonzalez Vanessa E, Porazzi Patrizia, Bhoj Vijay G, Apostolidis Sokratis A, Vogl Dan T, Porter David L, Scholler John, Diorio Caroline, Roche Aoife M, Everett John K, Bushman Frederic D, Nathanson Katherine L, Stadtmauer Edward A, Susanibar-Adaniya Sandra P, Garfall Alfred L, Ruella Marco, Cohen Adam D, Fraietta Joseph A

Substantial aircraft contrail formation at low soot emission levels

低烟尘排放水平下仍形成大量飞机尾迹

Voigt, Christiane; Märkl, Raphael; Sauer, Daniel; Dischl, Rebecca; Renard, Charles; Seeliger, Katharina; Yu, Fangqun; Kaufmann, Stefan; Bräuer, Tiziana; Jurkat-Witschas, Tina; Le Chenadec, Gauthier; Moreau, Julien; Requena-Esteban, Emiliano; Bonne, Nicolas; Vals, Margaux; Roche, Amandine; Zelina, Joseph; Dörnbrack, Andreas; Eirenschmalz, Lisa; Heckl, Christopher; Horst, Elisabeth; Lichtenstern, Michael; Marsing, Andreas; Neumann, Gregor; Roiger, Anke; Scheibe, Monika; Stock, Paul; Giez, Andreas; Eckel, Georg; Le Clercq, Patrick

Unearthing soil biodiversity through collaborative genomic research and education

通过合作基因组研究和教育揭示土壤生物多样性

Alberts, Tristen; Albritton, Claude F; Alcazar, Rosa; Aljabri, Zainab; Alvarez, Maria; Aradhey, Anish; Ayalew, Mentewab; Azizian, Nareh; Balayah, Yasmeen; Ball, Destiny D; Barragan, Efren; Beshoar, Corey; Best, Lyle; Biggane, Emily; Biggane, Joseph; Blick, Jesse; Blosser, Myron; Brown, Alex Kenneth; Campbell, Michael C; Canizares, Zoe; Chanhuhwa, Faith N; Chen, Yu; Chin, Daniel R; Chowdhury, Kamal; Collins, Tyler; Compton, Blair; Da Silva, Jefferson; Davis, Nia R; DeCaro, Natalie; Delgadillo, Frida; Deng, Youping; Duncan, Joceph; Egwu, Arinzechukwu C; Ekalle, Grace D; Elnawam, Noha; Enke, Ray; Ewhe, Naomi; Ferrel, Marco A; Fierst, Janna; Freymiller, Grace; Fuller, Karla; Fulton-Wright, Lena; Gaysinskaya, Valeriya; Gill, Torrence; Gillespie, Ellie; Gonzalez Moreno, Perla; Goodwin, Sara; Graham, Natajha; Graham, Madeline E; Graves, Joseph L Jr; Grob, Emily; Gutierrez, Rachael; Hager, Aisha; Hakim, Shazia Tabassum; Harris, Aaliyah; Hoffman, Ava M; Hoffmann, Tobias; Horton, Alani M; Hughes, Allison; Humphries, Elizabeth M; Ikechi-Konkwo, Josh-Samuel; Ishtiaq, Aadil; Jackson, Ryan; James, Joshua Ronnie; James, Kaitlan; Jamison, Sydney A; Jimenez, Armando; Johnson, Rachel; Kauffman, Abigail; Kaur, Harkiran; Kc, Kritika; Keeton, Analyse; Kelly, Olivia E; Kerr, Jennifer; Kucher, Nataliya; Kuehu, Donna Lee; Larson, Wendy A; Lee, Joslynn; Lee, Andrew; Leek, Jeffrey T; Lemaic, Danilo; Liburd, Lincoln E 2nd; Lopez, Alan Fernando; Mahmanzar, Mohammadamin; Mamae, Karwitha; Manjikian, Raffi; Marone, Michael; Marquez, Katerin; Martinson, Amara; Mavruk Eskipehlivan, Senem; Medrano, Ashley; Melendrez-Vallard, Melanie; Meller, Robert; Méndez, Loyda B; Mendez Gonzalez, Miguel P; Mesquita, Nicolli; Miller, Concepcion Martinez; Mohd-Ibrahim, Isam; Mortensen, Peter; Mosher, Stephen; Muja, Alketa; Nasrin, Nadia; Nasu, Masaki; Nguyen, Matthew H; Nguyen, Ba Thong; Nishiguchi, Michele; O'Connor, Lance M; Okie, Disomi; Olowookorun, Tolulope; Ostrovsky, Alex; Ozuna, Keyan; Pandey, Asmita; Patel, Shiv B; Paul, Gauri; Pawar, Shrikant; Pearson, Andrea; Petrik, Deborah; Platero, Jordan; Pontino, Carl; Pratap, Arjun P; Pratap, Siddharth; Qin, Yujia; Rai, Sudhir Kumar; Ray, Nisttha; Repesh, Ethan; Rhinehardt, Kristen; Roche, Brennan; Rodriguez, Ariana; Roy, Shriya; Roy, Sourav; Sawa, Alexa; Schatz, Michael C; Sen, Shurjo K; Serikawa, Randon; Smith, Tyler; Smith, Loraye; Sniezek, James; Stewart, Ryley D; Suarez-Martinez, Edu B; Taganna, Joelle; Tan, Frederick J; Tsotakos, Nikolaos; Udolisa, Nwanneka; Ulbricht, Katherine; Veo, Tanner; Vessio, Jennifer; Walker, Lia; Wang, Oscar; Wang, Qingguo; Wappel, Robert; Wesby, Kalynn; Whitford, Malachi; Wild, Nicole; Xie, Xianfa; Yang, Hua; York, Sayumi; Zirkle, Lindsay

Author Correction: Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

作者更正:靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Khoury, Nathalie; Pizzo, Michelle E; Discenza, Claire B; Joy, David; Tatarakis, David; Todorov, Mihail Ivilinov; Negwer, Moritz; Ha, Connie; De Melo, Gabrielly L; Sarrafha, Lily; Simon, Matthew J; Chan, Darren; Chau, Roni; Chew, Kylie S; Chow, Johann; Clemens, Allisa; Robles-Colmenares, Yaneth; Dugas, Jason C; Duque, Joseph; Kaltenecker, Doris; Kane, Holly; Leung, Amy; Lozano, Edwin; Moshkforoush, Arash; Roche, Elysia; Sandmann, Thomas; Tong, Mabel; Xa, Kaitlin; Zhou, Yinhan; Lewcock, Joseph W; Ertürk, Ali; Thorne, Robert G; Calvert, Meredith E K; Yu Zuchero, Y Joy

Mismatch repair deficiency drives malignant progression and alters the tumor immune microenvironment in glioblastoma models

错配修复缺陷驱动恶性进展并改变胶质母细胞瘤模型中的肿瘤免疫微环境

Puigdelloses Vallcorba, Montserrat; Soni, Nishant; Choi, Seung-Won; Rawat, Kavita; Joshi, Tanvi; Friedman, Sam; Buonfiglioli, Alice; Angione, Angelo; Chen, Zhihong; Piñero, Gonzalo; Price, Gabrielle; Dedhia, Mehek; Roche, Raina; Radkevich, Emir; Bowcock, Anne M; Bhatt, Deepti; Edelmann, Winfried; Samstein, Robert M; Richardson, Timothy E; Tsankova, Nadejda M; Tsankov, Alexander M; Bindra, Ranjit S; Rabadan, Raul; Vasquez, Juan C; Hambardzumyan, Dolores

Methodology for the Development of the Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI 2024-2025 Guidelines: From Evidence-to-Decision Frameworks to Digitalised Shared Decision-Making Algorithms

过敏性鼻炎及其对哮喘的影响(ARIA)-EAACI 2024-2025 指南制定方法:从循证决策框架到数字化共享决策算法

Bousquet, Jean; Sousa-Pinto, Bernardo; Vieira, Rafael José; Schünemann, Holger J; Zuberbier, Torsten; Bognanni, Antonio; Togias, Alkis; Samolinski, Boleslaw; Valiulis, Arunas; Williams, Sian; Bedbrook, Anna; Czarlewski, Wienczyslawa; Torres, Maria Jose; Shamji, Mohamed H; Morais-Almeida, Mário; Canonica, G Walter; Vecillas, Leticia de Las; Dykewicz, Mark S; Jacomelli, Cristina; Klimek, Ludger; Leemann, Lucas; Lourenço, Olga; Palamarchuk, Yuliia; Papadopoulos, Nikolaos G; Pereira, Ana Margarida; Savouré, Marine; Toppila-Salmi, Sanna K; Ventura, Maria Teresa; Yepes-Nuñez, Juan Jose; Cruz, Alvaro A; Ciprandi, Giorgio; Gemicioglu, Bilun; Giovannini, Mattia; Gradauskiene, Brigita; Jartti, Tuomas; Jeseňák, Miloš; Kuna, Piotr; Kvedariene, Violeta; Larenas-Linnemann, Désirée E; Latiff, Amir H A; Mohammad, Yousser; Ohta, Ken; Mahesh, Padukudru A; Pali-Schöll, Isabella; Pfaar, Oliver; Regateiro, Frederico S; Roche, Nicolas; Sofiev, Mikhail; Taborda-Barata, Luís; Ulrik, Charlotte Suppli; Rostan, Marylin Valentin; Viegi, Giovanni; Zhang, Luo; Antó, Josep M; Haahtela, Tari; Cherrez-Ojeda, Ivan; Ivancevich, Juan Carlos; Khaltaev, Nikolai; Yorgancioglu, Arzu; Abdullah, Baharudin; Al-Ahmad, Mona; Al-Nesf, Maryam Ali; Amaral, Rita; Asllani, Julijana; Bergmann, Karl-C; Bernstein, Jonathan A; Blaiss, Michael S; Braido, Fulvio; Camargos, Paulo; Carreiro-Martins, Pedro; Casale, Thomas; Cecchi, Lorenzo; Fiocchi, Alessandro G; Giuliano, Antonio F M; Christoff, George; Cirule, Ieva; Correia-de-Sousa, Jaime; Costa, Elisio M; Del Giacco, Stefano; Devillier, Philippe; Dokic, Dejan; Hossny, Elham; Iinuma, Tomohisa; Irani, Carla; Ispayeva, Zhanat; Julge, Kaja; Kaidashev, Igor; Bennoor, Kazi S; Kraxner, Helga; Kull, Inger; Kulus, Marek; Kupczyk, Maciej; Kurchenko, Andriy; La Grutta, Stefania; Miculinic, Neven; Tuyet, Lan Le Thi; Makris, Michael; Milenkovic, Branislava; Lee, Sang Min; Montefort, Stephen; Moreira, André; Mullol, Joaquim; Nadif, Rachel; Nakonechna, Alla; Neffen, Hugo E; Niedoszytko, Marek; Nyembue, Dieudonné; O'Hehir, Robyn; Ogulur, Ismail; Okamoto, Yoshitaka; Olze, Heidi; Palomares, Oscar; Panzner, Petr; Patella, Vincenzo; Pawankar, Ruby; Pitsios, Constantinos; Popov, Todor A; Puggioni, Francesca; Quirce, Santiago; Ramonaité, Agné; Recto, Marysia; Repka-Ramirez, Maria Susana; Roberts, Graham; Robles-Velasco, Karla; Rottem, Menachem; Salapatas, Marianella; Sastre, Joaquin; Scichilone, Nicola; Sisul, Juan Carlos; Solé, Dirceu; Soto-Martinez, Manuel E; Sova, Milan; Tantilipikorn, Pongsakorn; Todo-Bom, Ana; Tsaryk, Vladyslav; Tsiligianni, Ioanna; Urrutia-Pereira, Marilyn; Valovirta, Erkka; Van Ganse, Eric; Vasankari, Tuula; Wallace, Dana; Wang, De Yun; Worm, Margitta; Yusuf, Osman M; Zidarn, Mihaela; Gil-Mata, Sara; Marques-Cruz, Manuel; Mahboub, Bassam; Ansotegui, Ignacio J; Romano, Antonino; Artesani, Maria Cristina; Barreto, Bruno; Becker, Sven; Beghe, Bianca; Bouchard, Jacques; Bourgoin-Heck, Melisande; Brussino, Luisa; Buhl, Roland; Calvo-Gil, Mario; Dahl, Victoria Cardona; Vizuete, José Antonio Castillo; Charpin, Denis; Chavannes, Niels H; Chełmińska, Marta; Cheng, Lei; Chkhartishvili, Ekaterine; Chong-Neto, Herberto Jose; Choudhury, Deepa; Chu, Derek; Cingi, Cemal; Compalati, Enrico; Cvetkovski, Biljana; Da Silva, Jane; D'Amato, Gennaro; Davies, Janet; Di Bona, Danilo; Dimou, Maria V; Teixeira, Maria Do Ceu; Doulaptsi, Maria; Pérez, José Miguel Fuentes; Gawlik, Radoslaw; Goksel, Ozlem; Gómez, Maximiliano R; Gonzalez Diaz, Sandra N; Gotua, Maia; Grigoreas, Christos; Grisle, Ineta; Guzman, Maria Antonieta; Tan, Rachel House; Hyland, Michael; Ierodiakonou, Despo; Karavelia, Aspasia; Kisiel, Marta; Kosnik, Mitja; Kritikos, Vicky; Lombardi, Carlo; Martini, Matteo; Meço, Cem; Mesonjesi, Eris; Mihaltan, Florin; Moniuszko, Marcin; Naclerio, Robert; Neisinger, Sophia; Ordak, Michal; Paoletti, Giovanni; Perdomo-Flores, Edgar Arturo; Pham-Thi, Nhan; Prokopakis, Emmanuel; Yeverino, Daniela Rivero; Rolla, Giovanni; Romantowski, Jan; Rouadi, Philip W; Rukhadze, Maia; Sakurai, Daiju; Salameh, Laila; Sarquis, Faradiba Serpa; Kosak, Tanja Soklic; Soyka, Michael; Sozinova, Olga; Specjalski, Krzysztof; Tomic-Spiric, Vesna; Vachova, Martina; van Hage, Marianne; Koyuncu, Ilgim Vardaloglu; Vichyanond, Pakit; Wagenmann, Martin; Ko, Fanny Wai San; Werminghaus, Pascal; Xepapadaki, Vicky Paraskevi; Xiang, Yi-Kui; Fonseca, João A

Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part I-Guidelines on Intranasal Treatments

过敏性鼻炎及其对哮喘的影响(ARIA)-EAACI 指南-2024-2025 修订版:第一部分-鼻内治疗指南

Sousa-Pinto, Bernardo; Bousquet, Jean; Vieira, Rafael José; Schünemann, Holger J; Zuberbier, Torsten; Bognanni, Antonio; Togias, Alkis; Samolinski, Boleslaw; Valiulis, Arunas; Williams, Sian; Bedbrook, Anna; Czarlewski, Wienczyslawa; Torres, Maria Jose; Shamji, Mohamed H; Morais-Almeida, Mário; Canonica, G Walter; Vecillas, Leticia de Las; Dykewicz, Mark S; Jacomelli, Cristina; Klimek, Ludger; Leemann, Lucas; Lourenço, Olga; Palamarchuk, Yuliia; Papadopoulos, Nikolaos G; Pereira, Ana Margarida; Savouré, Marine; Toppila-Salmi, Sanna K; Ventura, Maria Teresa; Yepes-Nuñez, Juan José; Cruz, Alvaro A; Ciprandi, Giorgio; Gemicioglu, Bilun; Giovannini, Mattia; Gradauskiene, Brigita; Jartti, Tuomas; Jeseňák, Miloš; Kuna, Piotr; Kvedariene, Violeta; Larenas-Linnemann, Désirée E; Latiff, Amir Ha; Mohammad, Yousser; Ohta, Ken; Mahesh, Padukudru A; Pali-Schöll, Isabella; Pfaar, Oliver; Regateiro, Frederico S; Roche, Nicolas; Taborda-Barata, Luís; Ulrik, Charlotte Suppli; Rostan, Marylin Valentin; Viegi, Giovanni; Zhang, Luo; Haahtela, Tari; Cherrez-Ojeda, Ivan; Carlos Ivancevich, Juan; Khaltaev, Nikolai; Yorgancioglu, Arzu; Abdullah, Baharudin; Al-Ahmad, Mona; Al-Nesf, Maryam Ali; Amaral, Rita; Asllani, Julijana; Bergmann, Karl-C; Bernstein, Jonathan A; Blaiss, Michael S; Braido, Fulvio; Camargos, Paulo; Carreiro-Martins, Pedro; Casale, Thomas; Cecchi, Lorenzo; Fiocchi, Alessandro; Giuliano, Antonio F M; Christoff, George; Cirule, Ieva; de Sousa, Jaime Correia; Costa, Elisio M; Del Giacco, Stefano; Devillier, Philippe; Dokic, Dejan; Hossny, Elham; Iinuma, Tomohisa; Irani, Carla; Ispayeva, Zhanat; Julge, Kaja; Kaidashev, Igor; Bennoor, Kazi S; Kraxner, Helga; Kull, Inger; Kulus, Marek; Kupczyk, Maciej; Kurchenko, Andriy; La Grutta, Stefania; Miculinic, Neven; Tuyet, Lan Le Thi; Makris, Michael; Milenkovic, Branislava; Lee, Sang Min; Montefort, Stephen; Moreira, Andre; Mullol, Joaquim; Nadif, Rachel; Nakonechna, Alla; Neffen, Hugo E; Niedoszytko, Marek; Nyembue, Dieudonné; O'Hehir, Robyn E; Ogulur, Ismail; Okamoto, Yoshitaka; Olze, Heidi; Palomares, Oscar; Panzner, Petr; Patella, Vincenzo; Pawankar, Ruby; Pitsios, Constantinos; Popov, Todor A; Puggioni, Francesca; Quirce, Santiago; Ramonaité, Agné; Recto, Marysia; Repka-Ramirez, Maria Susana; Roberts, Graham; Robles-Velasco, Karla; Rottem, Menachem; Salapatas, Marianella; Sastre, Joaquin; Scichilone, Nicola; Sisul, Juan-Carlos; Solé, Dirceu; Soto-Martinez, Manuel E; Sova, Milan; Tantilipikorn, Pongsakorn; Todo-Bom, Ana; Tsaryk, Vladyslav; Tsiligianni, Ioanna; Urrutia-Pereira, Marilyn; Valovirta, Erkka; Vasankari, Tuula; Wallace, Dana; Wang, De Yun; Worm, Margitta; Yusuf, Osman M; Zidarn, Mihaela; Gil-Mata, Sara; Marques-Cruz, Manuel; Mahboub, Bassam; Ansotegui, Ignacio J; Romano, Antonino; Aberer, Werner; Artesani, Maria Cristina; Azzolini, Elena; Barreto, Bruno; Bartra, Joan; Becker, Sven; Beghe, Bianca; Boner, Attilio; Borowiack, Ewa; Bouchard, Jacques; Bourgoin-Heck, Melisande; Brussino, Luisa; Buhl, Roland; Castillo-Vizuete, José Antonio; Charpin, Denis; Chavannes, Niels H; Chełmińska, Marta; Cheng, Lei; Chkhartishvili, Ekaterine; Cho, Seong H; Chong-Neto, Herberto Jose; Choudhury, Deepa; Chu, Derek K; Cingi, Cemal; Compalati, Enrico; Costa, Raquel Albuquerque; Cunha, Olga Mariana; Cvetkovski, Biljana; Cardona-Dahl, Victoria; D'Amato, Gennaro; Davies, Janet; Di Bona, Danilo; Gonzalez Diaz, Sandra N; Dimou, Maria V; Doulaptsi, Maria; Ferreira-da-Silva, Renato; Gawlik, Radoslaw; Calvo-Gil, Mario; Goksel, Ozlem; Gómez, Maximiliano R; Gotua, Maia; Grigoreas, Christos; Grisle, Ineta; Guzman, Maria Antonieta; Tan, Rachel House; Hyland, Michael; Ierodiakonou, Despo; Karavelia, Aspasia; Keith, Paul; Kisiel, Marta; Kosak, Tanja Soklic; Kosnik, Mitja; Koyuncu, Ilgim Vardaloglu; Kritikos, Vicky; Litynska, Justyna; Lombardi, Carlo; Louis, Gilles; Martini, Matteo; Meço, Cem; Mesonjesi, Eris; Mihaltan, Florin; Moniuszko, Marcin; Naclerio, Robert N; Nadeau, Kari C; Neisinger, Sophia; Ollert, Markus; Ordak, Michal; Paoletti, Giovanni; Park, Hae-Sim; Parmelli, Elena; Perdomo-Flores, Edgar Arturo; Pérez, José Miguel Fuentes; Pham-Thi, Nhan; Prokopakis, Emmanuel; Ribeiro-Vaz, Inês; Rolla, Giovanni; Romantowski, Jan; Rombaux, Philippe; Rouadi, Philip W; Rukhadze, Maia; Ryan, Dermot; Sadowska, Ewelina; Sakurai, Daiju; Salameh, Laila; Sarquis, Faradiba Serpa; Serrano, Elie; Da Silva, Jane; Soyka, Michael; Specjalski, Krzysztof; Tomic-Spiric, Vesna; Stevanovic, Katarina; Subramaniam, Abirami; Teixeira, Maria Do Ceu; Thomander, Tuuli; Vachova, Martina; van Hage, Marianne; Vichyanond, Pakit; Wagenmann, Martin; Ko, Fanny Wai San; Werminghaus, Pascal; Xepapadaki, Paraskevi Vicky; Xiang, Yi-Kui; Yang, Qintai; Yeverino, Daniela Rivero; Zuberbier, Jaron; Fonseca, João A

No serum estradiol changes with 5-alpha reductase inhibitors for late alopecia in cancer survivors: A retrospective cohort study

癌症幸存者晚期脱发患者使用5α-还原酶抑制剂治疗后,血清雌二醇水平无变化:一项回顾性队列研究

Ong, Michael M; Mittal, Lavanya; Lacouture, Mario; Dusza, Stephen; Gordon, Allison; Bromberg, Jacqueline F; Goldfarb, Shari B; Iyengar, Neil M; Long Roche, Kara; Markova, Alina

Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil.

雷迪普罗地尔对含 GluN2B 的 N-甲基-D-天冬氨酸受体的抑制作用。

Banke Tue G, Regan Michael C, Perszyk Riley E, Zhang Lu, Xing Hao, Chen Jiahui, Won Sehoon, Simorowski Noriko, Diaz Eva S, Kim Sukhan, Song Rui, Rong Jian, Zhou Xin, Chaudhary Ahmad F, Zhang Jing, Traynelis John F, McDaniels Ellington D, Nitsche Karolina, Roache Steve, Raymond Christopher S, Low Chian-Ming, Myers Scott J, Roche Katherine W, Liang Steven H, Traynelis Stephen F, Furukawa Hiro, Yuan Hongjie

Taxation of foods high in fat, sugar, and sodium in India: A modelling study of health and economic impacts

印度对高脂肪、高糖和高钠食品征税:健康和经济影响的建模研究

Roche, Maxime; Zhu, Jingmin; Olney, Jack; Laydon, Daniel J; Joe, William; Sharma, Manika; Steele, Lindsay; Sassi, Franco