日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

P-stalk ribosomes act as master regulators of cytokine-mediated processes

P-stalk核糖体是细胞因子介导过程的主要调控因子。

Anna Dopler ,Ferhat Alkan ,Yuval Malka ,Rob van der Kammen ,Kelly Hoefakker ,Daniel Taranto ,Naz Kocabay ,Iris Mimpen ,Christel Ramirez ,Elke Malzer ,Olga I Isaeva ,Mandy Kerkhoff ,Anastasia Gangaev ,Joana Silva ,Sofia Ramalho ,Liesbeth Hoekman ,Maarten Altelaar ,Roderick Beijersbergen ,Leila Akkari ,Jonathan Wilson Yewdell ,Pia Kvistborg ,William James Faller

Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

基因筛查揭示了 BAP1 缺陷间皮瘤中新的可靶向弱点

Gaurav Kumar Pandey, Nick Landman, Hannah K Neikes, Danielle Hulsman, Cor Lieftink, Roderick Beijersbergen, Krishna Kalyan Kolluri, Sam M Janes, Michiel Vermeulen, Jitendra Badhai, Maarten van Lohuizen

Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity

管腔乳腺癌的身份取决于糖皮质激素受体活性的丧失

Stefan Prekovic #, Theofilos Chalkiadakis #, Merel Roest #, Daniel Roden, Catrin Lutz, Karianne Schuurman, Mark Opdam, Liesbeth Hoekman, Nina Abbott, Tanja Tesselaar, Maliha Wajahat, Amy R Dwyer, Isabel Mayayo-Peralta, Gabriela Gomez, Maarten Altelaar, Roderick Beijersbergen, Balázs Győrffy, Leonie

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

糖皮质激素受体在肺癌中触发一种可逆的耐药性休眠状态,这种状态会获得治疗上的脆弱性。

Stefan Prekovic # ,Karianne Schuurman # ,Isabel Mayayo-Peralta ,Anna G Manjón ,Mark Buijs ,Selçuk Yavuz ,Max D Wellenstein ,Alejandro Barrera ,Kim Monkhorst ,Anne Huber ,Ben Morris ,Cor Lieftink ,Theofilos Chalkiadakis ,Ferhat Alkan ,Joana Silva ,Balázs Győrffy ,Liesbeth Hoekman ,Bram van den Broek ,Hans Teunissen ,Donna O Debets ,Tesa Severson ,Jos Jonkers ,Timothy Reddy ,Karin E de Visser ,William Faller ,Roderick Beijersbergen ,Maarten Altelaar ,Elzo de Wit ,Rene Medema ,Wilbert Zwart

A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer

以激酶组为中心的 CRISPR-Cas9 筛选可识别活化的 BRAF 以调节恩杂鲁胺耐药性,对 BRAF 突变前列腺癌具有潜在的治疗意义

Sander A L Palit, Jeroen van Dorp, Daniel Vis, Cor Lieftink, Simon Linder, Roderick Beijersbergen, Andries M Bergman, Wilbert Zwart, Michiel S van der Heijden

Ribociclib Induces Broad Chemotherapy Resistance and EGFR Dependency in ESR1 Wildtype and Mutant Breast Cancer

Ribociclib 在 ESR1 野生型和突变型乳腺癌中诱导广泛的化疗耐药性和 EGFR 依赖性

Isabel Mayayo-Peralta, Beatrice Faggion, Liesbeth Hoekman, Ben Morris, Cor Lieftink, Isabella Goldsbrough, Lakjaya Buluwela, Joseph C Siefert, Harm Post, Maarten Altelaar, Roderick Beijersbergen, Simak Ali, Wilbert Zwart, Stefan Prekovic

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

针对谷氨酰胺成瘾的强效药物组合策略用于治疗人类肝癌

Haojie Jin #, Siying Wang #, Esther A Zaal #, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards

TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth

TLE3 缺失通过促进 GR 介导的人类前列腺癌细胞生长而产生 AR 抑制剂耐药性

Sander Al Palit, Daniel Vis, Suzan Stelloo, Cor Lieftink, Stefan Prekovic, Elise Bekers, Ingrid Hofland, Tonći Šuštić, Liesanne Wolters, Roderick Beijersbergen, Andries M Bergman, Balázs Győrffy, Lodewyk Fa Wessels, Wilbert Zwart, Michiel S van der Heijden

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation

综合基因组学方法确定 PI3K/AKT/FOXO 通路参与乳腺癌肿瘤发生

Linda Smit, Katrien Berns, Katherine Spence, W David Ryder, Nik Zeps, Mandy Madiredjo, Roderick Beijersbergen, René Bernards, Robert B Clarke

The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1

Cdk1 抑制的致死反应取决于 KIF4 和 PRC1 异构体 1 产生的姐妹染色单体比对错误

Erik Voets, Judith Marsman, Jeroen Demmers, Roderick Beijersbergen, Rob Wolthuis