日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of N‑Acylhydrazone Derivatives as ROCK Inhibitors: A Journey from Virtual Screening and Structure-Based De Novo Design to the Identification of ROCK2 Selective Inhibitors and Beyond

N-酰基腙衍生物作为ROCK抑制剂的发现：从虚拟筛选和基于结构的从头设计到ROCK2选择性抑制剂的鉴定及其他

期刊:ACS Bio & Med Chem Au
影响因子:4.3
doi:10.1021/acsbiomedchemau.5c00246
Pinheiro, Pedro de Sena Murteira; Silva Franco, Lucas; Pillpe-Meza, Raysa Magali; de Jesus, Bárbara da Silva Mascarenhas; Martins, Gabrielli Ayumi Ito; Gouveia, Wesley Leandro; Rodrigues, Daniel Alencar; Alves, Marina Amaral; Lima, Lídia Moreira
ROCK2
ROCK
发表日期：2026
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Design, Synthesis, and Biological Evaluation of Novel Triazine-Based Dual Histone Deacetylase/phosphatidylinositol 3-kinase Inhibitors for Breast Cancer Therapy

用于乳腺癌治疗的新型三嗪类双重组蛋白去乙酰化酶/磷脂酰肌醇3-激酶抑制剂的设计、合成和生物学评价

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.202501041
Luzietti, Lara; Pires, Gustavo Salgado; Ryan, Ana; Regidor, Crisamie; Hiller, Matthew; Sarti, Danilo; Ní Chonghaile, Tríona; Pinheiro, Pedro de Sena Murteira; Varešlija, Damir; Rodrigues, Daniel Alencar
信号转导
表观遗传
乙酰化
乳腺癌
肿瘤
肿瘤免疫
发表日期：2026
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Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups

组蛋白去乙酰化酶抑制剂的药物发现：锌结合基团的过去、现在和未来

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph18040577
Pires, Gustavo Salgado; Tolomeu, Heber Victor; Rodrigues, Daniel Alencar; Lima, Lídia Moreira; Fraga, Carlos Alberto Manssour; Pinheiro, Pedro de Sena Murteira
表观遗传
乙酰化
发表日期：2025
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Drug Repurposing by Virtual Screening: Identification of New Already Approved ROCK Inhibitors as Promising Drugs to Target Neurodegeneration.

通过虚拟筛选进行药物再利用：识别已获批准的新型 ROCK 抑制剂作为治疗神经退行性疾病的潜在药物

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.5c04340
Silva Franco Lucas, Rodrigues Daniel Alencar, Baumart Gabriela Joras, de Jesus Bárbara da Silva Mascarenhas, Gomes Flávia Carvalho Alcantara, Lima Lídia Moreira, Fraga Carlos Alberto Manssour, Pinheiro Pedro de Sena Murteira
神经科学
发表日期：2025
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Novel Single Inhibitor of HDAC6/8 and Dual Inhibitor of PI3K/HDAC6 as Potential Alternative Treatments for Prostate Cancer

新型HDAC6/8单抑制剂和PI3K/HDAC6双重抑制剂作为前列腺癌的潜在替代疗法

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph14050387
Guerra, Fabiana Sélos; Rodrigues, Daniel Alencar; Fraga, Carlos Alberto Manssour; Fernandes, Patricia Dias
肿瘤
前列腺癌
肿瘤免疫
HDAC6
发表日期：2021
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