日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii

利用非糖基化单克隆抗体提高柯马加塔氏菌(Komagataella phaffii)的产量

Yang, Yuchen; Dalvie, Neil C; Brady, Joseph R; Naranjo, Christopher A; Lorgeree, Timothy; Rodriguez-Aponte, Sergio A; Johnston, Ryan S; Tracey, Mary K; Elenberger, Carmen M; Lee, Eric; Tié, Mark; Love, Kerry R; Love, J Christopher

Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies

引发剂暂时降低游离 DNA 的清除率,以改善液体活检

Carmen Martin-Alonso #, Shervin Tabrizi #, Kan Xiong #, Timothy Blewett, Sainetra Sridhar, Andjela Crnjac, Sahil Patel, Zhenyi An, Ahmet Bekdemir, Douglas Shea, Shih-Ting Wang, Sergio Rodriguez-Aponte, Christopher A Naranjo, Justin Rhoades, Jesse D Kirkpatrick, Heather E Fleming, Ava P Amini, Todd R

Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract

针对粘膜淋巴组织的疫苗可促进胃肠道体液免疫

Ozgun Kocabiyik, Parastoo Amlashi, A Lina Vo, Heikyung Suh, Sergio A Rodriguez-Aponte, Neil C Dalvie, J Christopher Love, Raiees Andrabi, Darrell J Irvine

CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome

CRISPR-Cas9基因敲除筛选揭示了有效减少Komagataella phaffii分泌组的方法

Dalvie, Neil C; Lorgeree, Timothy R; Yang, Yuchen; Rodriguez-Aponte, Sergio A; Whittaker, Charles A; Hinckley, Joshua A; Clark, John J; Del Rosario, Amanda M; Love, Kerry R; Love, J Christopher

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants.

对刺突蛋白 RBD 中隐蔽表位进行分子工程改造,可提高其生产性能和对 SARS-CoV-2 变种的中和广度

Rodriguez-Aponte Sergio A, Dalvie Neil C, Wong Ting Y, Johnston Ryan S, Naranjo Christopher A, Bajoria Sakshi, Kumru Ozan S, Kaur Kawaljit, Russ Brynnan P, Lee Katherine S, Cyphert Holly A, Barbier Mariette, Rao Harish D, Rajurkar Meghraj P, Lothe Rakesh R, Shaligram Umesh S, Batwal Saurabh, Chandrasekaran Rahul, Nagar Gaurav, Kleanthous Harry, Biswas Sumi, Bevere Justin R, Joshi Sangeeta B, Volkin David B, Damron F Heath, Love J Christopher

Large-Scale Purification and Characterization of Recombinant Receptor-Binding Domain (RBD) of SARS-CoV-2 Spike Protein Expressed in Yeast

大规模纯化和表征在酵母中表达的SARS-CoV-2刺突蛋白重组受体结合域(RBD)

Nagar, Gaurav; Jain, Siddharth; Rajurkar, Meghraj; Lothe, Rakesh; Rao, Harish; Majumdar, Sourav; Gautam, Manish; Rodriguez-Aponte, Sergio A; Crowell, Laura E; Love, J Christopher; Dandekar, Prajakta; Puranik, Amita; Gairola, Sunil; Shaligram, Umesh; Jain, Ratnesh

Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018(TM) Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen

含氢氧化铝和CpG 1018(TM)佐剂的纳米明矾制剂:对重组SARS-CoV-2 RBD抗原稳定性和免疫原性的影响

Bajoria, Sakshi; Kumru, Ozan S; Doering, Jennifer; Berman, Katherine; Slyke, Greta Van; Prigodich, Anneka; Rodriguez-Aponte, Sergio A; Kleanthous, Harry; Love, J Christopher; Mantis, Nicholas J; Joshi, Sangeeta B; Volkin, David B

Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity

鼻内接种脂质体偶联免疫原可促进抗原经黏膜吸收,从而增强黏膜和全身免疫力。

Hartwell, Brittany L; Melo, Mariane B; Xiao, Peng; Lemnios, Ashley A; Li, Na; Chang, Jason Y H; Yu, Jingyou; Gebre, Makda S; Chang, Aiquan; Maiorino, Laura; Carter, Crystal; Moyer, Tyson J; Dalvie, Neil C; Rodriguez-Aponte, Sergio A; Rodrigues, Kristen A; Silva, Murillo; Suh, Heikyung; Adams, Josetta; Fontenot, Jane; Love, J Christopher; Barouch, Dan H; Villinger, Francois; Ruprecht, Ruth M; Irvine, Darrell J

SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques

HBsAg 病毒样颗粒上展示的 SARS-CoV-2 受体结合域在恒河猴中引发保护性免疫

Neil C Dalvie, Lisa H Tostanoski, Sergio A Rodriguez-Aponte, Kawaljit Kaur, Sakshi Bajoria, Ozan S Kumru, Amanda J Martinot, Abishek Chandrashekar, Katherine McMahan, Noe B Mercado, Jingyou Yu, Aiquan Chang, Victoria M Giffin, Felix Nampanya, Shivani Patel, Lesley Bowman, Christopher A Naranjo, Dong

Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii

端的空间可及性提高了 Komagataella phaffii 分泌的重组蛋白的滴度和质量

Neil C Dalvie #, Christopher A Naranjo #, Sergio A Rodriguez-Aponte #, Ryan S Johnston, J Christopher Love