日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight Loss in Diet-Induced Obese Mice

胆汁酸结合树脂可改善饮食诱导肥胖小鼠中胰高血糖素受体激动剂介导的体重减轻

Kim, Teayoun; Pearson, Mackenzie J; Hong, Huixian; Nason, Shelly; Seck, Khadija; Antipenko, Jessica; Presedo, Natalie; DiMarchi, Richard; Roell, William C; Habegger, Kirk

Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

瑞他曲肽治疗后循环 ANGPTL3/8 浓度的降低与血脂的降低平行。

Wen, Yi; Lemen, Deven; Lin, Yanzhu; Chen, Yan Q; Regmi, Ajit; Roell, William C; Thomas, Melissa K; Hartman, Mark L; Coskun, Tamer; Milicevic, Zvonko; Haupt, Axel; Ruotolo, Giacomo; Konrad, Robert J

The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist, tirzepatide, improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes

替泽帕肽是一种双重葡萄糖依赖性促胰岛素肽和胰高血糖素样肽-1受体激动剂,可改善2型糖尿病患者与胰岛素抵抗和心血管风险相关的脂蛋白生物标志物。

Wilson, Jonathan M; Nikooienejad, Amir; Robins, Deborah A; Roell, William C; Riesmeyer, Jeffrey S; Haupt, Axel; Duffin, Kevin L; Taskinen, Marja-Riitta; Ruotolo, Giacomo

Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization

抑制钠-葡萄糖协同转运蛋白2可在局部心肌缺血期间维持心脏功能,且该作用独立于心肌底物利用的改变。

Baker, Hana E; Kiel, Alexander M; Luebbe, Samuel T; Simon, Blake R; Earl, Conner C; Regmi, Ajit; Roell, William C; Mather, Kieren J; Tune, Johnathan D; Goodwill, Adam G

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

LY3298176,一种用于治疗2型糖尿病的新型双重GIP和GLP-1受体激动剂:从发现到临床概念验证

Coskun, Tamer; Sloop, Kyle W; Loghin, Corina; Alsina-Fernandez, Jorge; Urva, Shweta; Bokvist, Krister B; Cui, Xuewei; Briere, Daniel A; Cabrera, Over; Roell, William C; Kuchibhotla, Uma; Moyers, Julie S; Benson, Charles T; Gimeno, Ruth E; D'Alessio, David A; Haupt, Axel

Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587.

CXCR4肽拮抗剂LY2510924和单克隆抗体LY2624587可显著动员白细胞和造血干细胞

Peng Sheng-Bin, Van Horn Robert D, Yin Tinggui, Brown Robin M, Roell William C, Obungu Victor H, Ruegg Charles, Wroblewski Victor J, Raddad Eyas, Stille John R