日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.

拓扑异构酶抑制剂Topobexin靶向拓扑异构酶II ATPase结构域，选择性抑制β亚型，发挥蒽环类药物心脏保护作用

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-60167-9
Kubeš Jan, Karabanovich Galina, Cong Anh T Q, Melnikova Iuliia, Lenčová Olga, Kollárová Petra, Bavlovič Piskáčková Hana, Keresteš Veronika, Applová Lenka, Arrouye Lise C M, Alvey Julia R, Paluncic Jasmina, Witter Taylor L, Jirkovská Anna, Kuneš Jiří, Štěrbová-Kovaříková Petra, Austin Caroline A, Štěrba Martin, Šimůnek Tomáš, Roh Jaroslav, Schellenberg Matthew J
其它
药物研究
发表日期：2025
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Revolutionizing tuberculosis treatment: Breakthroughs, challenges, and hope on the horizon

结核病治疗的革命性变革：突破、挑战与希望

期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2025.01.023
Kufa, Martin; Finger, Vladimir; Kovar, Ondrej; Soukup, Ondrej; Torruellas, Carilyn; Roh, Jaroslav; Korabecny, Jan
发表日期：2025
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Daunorubicin and its hydroxy metabolite in cardiomyocytes: insights into cellular kinetics, toxicity, DNA damage, and dexrazoxane-induced cardioprotection.

柔红霉素及其羟基代谢物在心肌细胞中的作用：对细胞动力学、毒性、DNA损伤和右雷佐生诱导的心脏保护作用的深入了解

期刊:Archives of Toxicology
影响因子:6.9
doi:10.1007/s00204-025-04095-z
Applová Lenka, Dudášová-Hatoková Paulína, Kubeš Jan, Váňová Nela, Keresteš Veronika, Reguli Adam, Jirkovská Anna, Roh Jaroslav, Štěrba Martin, Štěrbová-Kovaříková Petra, Šimůnek Tomáš
代谢
细胞生物学
心肌炎
发表日期：2025
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Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies

结核病药物研发中的骨架跃迁：原理、应用和案例研究

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01100
Kovar, Ondrej; Kufa, Martin; Finger, Vladimir; Soukup, Ondrej; Kratky, Martin; Torruellas, Carilyn; Roh, Jaroslav; Korabecny, Jan
发表日期：2025
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Rapid method for screening of both calcium and magnesium chelation with comparison of 21 known metal chelators

一种快速筛选钙镁螯合剂并与21种已知金属螯合剂进行比较的方法

期刊:Journal of Biological Inorganic Chemistry
影响因子:2.7
doi:10.1007/s00775-024-02078-6
Konečný, Lukáš; Lomozová, Zuzana; Karabanovich, Galina; Roh, Jaroslav; Vávrová, Kateřina; Mladěnka, Přemysl
发表日期：2024
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Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers

脯氨酸、羟脯氨酸和吡咯烷酮羧酸衍生物作为高效但可逆的透皮渗透促进剂

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-022-24108-6
Kopečná, Monika; Macháček, Miloslav; Roh, Jaroslav; Vávrová, Kateřina
发表日期：2022
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Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity

开发水溶性双二氧哌嗪拓扑异构酶IIβ抑制剂ICRF-193前药作为潜在的抗蒽环类药物心脏毒性的心脏保护剂

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-021-83688-x
Bavlovič Piskáčková, Hana; Jansová, Hana; Kubeš, Jan; Karabanovich, Galina; Váňová, Nela; Kollárová-Brázdová, Petra; Melnikova, Iuliia; Jirkovská, Anna; Lenčová-Popelová, Olga; Chládek, Jaroslav; Roh, Jaroslav; Šimůnek, Tomáš; Štěrba, Martin; Štěrbová-Kovaříková, Petra
毒理研究
发表日期：2021
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Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

新型高效的抗肿瘤和抗转移二(2-吡啶基)酮硫代氨基脲类化合物在第一代和第二代先导化合物的药理学特性方面表现出显著差异。

期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.6389
Sestak, Vit; Stariat, Jan; Cermanova, Jolana; Potuckova, Eliska; Chladek, Jaroslav; Roh, Jaroslav; Bures, Jan; Jansova, Hana; Prusa, Petr; Sterba, Martin; Micuda, Stanislav; Simunek, Tomas; Kalinowski, Danuta S; Richardson, Des R; Kovarikova, Petra
肿瘤
肿瘤免疫
发表日期：2015
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