Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease
利用多顺反子慢病毒载体介导的纹状体基因转移，将芳香族L-氨基酸脱羧酶、酪氨酸羟化酶和GTP环化水解酶I导入帕金森病大鼠模型，可诱导转基因的持续表达、多巴胺的产生以及功能改善。
期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.22-23-10302.2002
Azzouz, Mimoun; Martin-Rendon, Enca; Barber, Robert D; Mitrophanous, Kyriacos A; Carter, Emma E; Rohll, Jonathan B; Kingsman, Susan M; Kingsman, Alan J; Mazarakis, Nicholas D
