日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue

单个抗体残基通过四聚体解离和活性位点变构作用完全抑制β-胰蛋白酶

Maun, Henry R; Azumaya, Caleigh M; Walters, Benjamin T; Vij, Rajesh; Morando, Ashley; Loyet, Kelly M; Koerber, James T; Rohou, Alexis; Lazarus, Robert A

Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM

二硫键约束的Fab片段克服了高分辨率单颗粒冷冻电镜成像的目标尺寸限制。

Kung, Jennifer E; Johnson, Matthew C; Tegunov, Dimitry; Jao, Christine C; Wu, Ping; Oh, Angela; Lin, May; Daria, Jose M; Koth, Christopher M; Arthur, Christopher P; Rohou, Alexis; Sudhamsu, Jawahar

Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera.

VHL募集嵌合体通过化学方法诱导内质网应激传感器IRE1的降解。

Du Jin, Villemure Elisia, Johnson Matthew, Azumaya Caleigh, Gaspar Catarina J, Marsters Scot, Lawrence David, Foster Scott, Rohou Alexis, Cheung Tommy K, Rose Christopher M, Garner Thomas, Ro Soo, Clark Kevin, Beresini Maureen H, Braun Marie-Gabrielle, Rudolph Joachim, Hsu Peter, Ashkenazi Avi

Community recommendations on cryoEM data archiving and validation

关于冷冻电镜数据存档和验证的社区建议

Kleywegt, Gerard J; Adams, Paul D; Butcher, Sarah J; Lawson, Catherine L; Rohou, Alexis; Rosenthal, Peter B; Subramaniam, Sriram; Topf, Maya; Abbott, Sanja; Baldwin, Philip R; Berrisford, John M; Bricogne, Gérard; Choudhary, Preeti; Croll, Tristan I; Danev, Radostin; Ganesan, Sai J; Grant, Timothy; Gutmanas, Aleksandras; Henderson, Richard; Heymann, J Bernard; Huiskonen, Juha T; Istrate, Andrei; Kato, Takayuki; Lander, Gabriel C; Lok, Shee Mei; Ludtke, Steven J; Murshudov, Garib N; Pye, Ryan; Pintilie, Grigore D; Richardson, Jane S; Sachse, Carsten; Salih, Osman; Scheres, Sjors H W; Schroeder, Gunnar F; Sorzano, Carlos Oscar S; Stagg, Scott M; Wang, Zhe; Warshamanage, Rangana; Westbrook, John D; Winn, Martyn D; Young, Jasmine Y; Burley, Stephen K; Hoch, Jeffrey C; Kurisu, Genji; Morris, Kyle; Patwardhan, Ardan; Velankar, Sameer

Cryo-EM reveals an unprecedented binding site for Na(V)1.7 inhibitors enabling rational design of potent hybrid inhibitors

冷冻电镜揭示了Na(V)1.7抑制剂前所未有的结合位点,从而能够合理设计高效的混合抑制剂。

Kschonsak, Marc; Jao, Christine C; Arthur, Christopher P; Rohou, Alexis L; Bergeron, Philippe; Ortwine, Daniel F; McKerrall, Steven J; Hackos, David H; Deng, Lunbin; Chen, Jun; Li, Tianbo; Dragovich, Peter S; Volgraf, Matthew; Wright, Matthew R; Payandeh, Jian; Ciferri, Claudio; Tellis, John C

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.

CARD9 的自抑制和聚合形式的结构揭示了 CARD9 和 CARD11 激活的机制

Holliday Michael J, Witt Axel, Rodríguez Gama Alejandro, Walters Benjamin T, Arthur Christopher P, Halfmann Randal, Rohou Alexis, Dueber Erin C, Fairbrother Wayne J

Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9

皮摩尔级锌结合调节CARD9的caspase募集结构域(CARD)中Bcl10成核组装体的形成。

Holliday, Michael J; Ferrao, Ryan; de Leon Boenig, Gladys; Estevez, Alberto; Helgason, Elizabeth; Rohou, Alexis; Dueber, Erin C; Fairbrother, Wayne J

Structure of the SLC4 transporter Bor1p in an inward-facing conformation

SLC4转运蛋白Bor1p的内向构象结构

Coudray, Nicolas; L Seyler, Sean; Lasala, Ralph; Zhang, Zhening; Clark, Kathy M; Dumont, Mark E; Rohou, Alexis; Beckstein, Oliver; Stokes, David L

Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

利用冷冻电镜技术研究牛线粒体ATP合酶的结构和构象状态

Zhou, Anna; Rohou, Alexis; Schep, Daniel G; Bason, John V; Montgomery, Martin G; Walker, John E; Grigorieff, Nikolaus; Rubinstein, John L