Phase I Study of Epigenetic Priming with Azacitidine Prior to Standard Neoadjuvant Chemotherapy for Patients with Resectable Gastric and Esophageal Adenocarcinoma: Evidence of Tumor Hypomethylation as an Indicator of Major Histopathologic Response
一项针对可切除胃癌和食管腺癌患者的I期临床研究:在标准新辅助化疗前使用阿扎胞苷进行表观遗传学启动,以评估肿瘤低甲基化作为主要组织病理学反应指标的证据。
期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-16-1896
Schneider, Bryan J; Shah, Manish A; Klute, Kelsey; Ocean, Allyson; Popa, Elizabeta; Altorki, Nasser; Lieberman, Michael; Schreiner, Andrew; Yantiss, Rhonda; Christos, Paul J; Palmer, Romae; You, Daoqi; Viale, Agnes; Kermani, Pouneh; Scandura, Joseph M