日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An inducible CRISPRi system for phenotypic analysis of essential genes in Pseudomonas aeruginosa.

用于铜绿假单胞菌必需基因表型分析的诱导型 CRISPRi 系统。

Sullivan Jaryd R, Ferrara Kristina M, Barrick Rebecca, Romano Keith P, Warrier Thulasi, Hung Deborah T

Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.

通过多重筛选发现了一种靶向铜绿假单胞菌外膜蛋白 OprH-LPS 相互作用的小分子

Poulsen Bradley E, Warrier Thulasi, Barkho Sulyman, Bagnall Josephine, Romano Keith P, White Tiantian, Yu Xiao, Kawate Tomohiko, Nguyen Phuong H, Raines Kyra, Ferrara Kristina, Golas A Lorelei, FitzGerald Michael, Boeszoermenyi Andras, Kaushik Virendar, Serrano-Wu Michael, Shoresh Noam, Hung Deborah T

Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics

扰动特异性转录组图谱分析用于无偏倚地阐明抗生素靶点

Romano, Keith P; Bagnall, Josephine; Warrier, Thulasi; Sullivan, Jaryd; Ferrara, Kristina; Orzechowski, Marek; Nguyen, Phuong H; Raines, Kyra; Livny, Jonathan; Shoresh, Noam; Hung, Deborah T

Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation

整合基因组学和化学生物学预示着一个精密抗菌药物发现的新时代,从确定关键基因到阐明靶点。

Warrier, Thulasi; Romano, Keith P; Clatworthy, Anne E; Hung, Deborah T

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa

pmrB基因突变导致铜绿假单胞菌对LptD抑制剂POL7080和粘菌素产生交叉耐药性

Romano, Keith P; Warrier, Thulasi; Poulsen, Bradley E; Nguyen, Phuong H; Loftis, Alexander R; Saebi, Azin; Pentelute, Bradley L; Hung, Deborah T

Whole-organism phenotypic screening for anti-infectives promoting host health

针对促进宿主健康的抗感染药物进行全生物体表型筛选

Clatworthy, Anne E; Romano, Keith P; Hung, Deborah T

Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance

评估大环化合物在丙型肝炎病毒NS3/4A蛋白酶抑制剂耐药性中的作用

Ali, Akbar; Aydin, Cihan; Gildemeister, Reinhold; Romano, Keith P; Cao, Hong; Ozen, Ayşegül; Soumana, Djade; Newton, Alicia; Petropoulos, Christos J; Huang, Wei; Schiffer, Celia A

The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors

丙型肝炎病毒NS3/4A蛋白酶抑制剂耐药性的分子基础

Romano, Keith P; Ali, Akbar; Aydin, Cihan; Soumana, Djade; Ozen, Ayşegül; Deveau, Laura M; Silver, Casey; Cao, Hong; Newton, Alicia; Petropoulos, Christos J; Huang, Wei; Schiffer, Celia A

Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease

丙型肝炎病毒NS3/4A蛋白酶识别病毒和宿主细胞底物的分子机制

Romano, Keith P; Laine, Jennifer M; Deveau, Laura M; Cao, Hong; Massi, Francesca; Schiffer, Celia A