日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector

利用AAV载体研究抗朊病毒蛋白纳米抗体对朊病毒疾病的体内作用

Jingjing Zhang ,Mengfei Wang ,Dan Wang ,Xiangyi Zhang ,Yue Ma ,Els Pardon ,Jan Steyaert ,Romany Abskharon ,Fei Wang ,Jiyan Ma

D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease

肽磁性纳米粒子碎裂 tau 纤维并挽救阿尔茨海默病小鼠模型中的行为缺陷

Ke Hou, Hope Pan, Hedieh Shahpasand-Kroner, Carolyn Hu, Romany Abskharon, Paul Seidler, Marisa Mekkittikul, Melinda Balbirnie, Carter Lantz, Michael R Sawaya, Joshua L Dolinsky, Mychica Jones, Xiaohong Zuo, Joseph A Loo, Sally Frautschy, Greg Cole, David S Eisenberg

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

SARS-CoV-2 核衣壳蛋白的低复杂度结构域形成淀粉样蛋白原纤维

Einav Tayeb-Fligelman, Jeannette T Bowler, Christen E Tai, Michael R Sawaya, Yi Xiao Jiang, Gustavo Garcia Jr, Sarah L Griner, Xinyi Cheng, Lukasz Salwinski, Liisa Lutter, Paul M Seidler, Jiahui Lu, Gregory M Rosenberg, Ke Hou, Romany Abskharon, Hope Pan, Chih-Te Zee, David R Boyer, Yan Li, Daniel H

Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method

TFG 蛋白突变体的纤维结构通过 IMPAcT 方法验证了 TFG 为疾病相关的淀粉样蛋白

Gregory M Rosenberg, Romany Abskharon, David R Boyer, Peng Ge, Michael R Sawaya, David S Eisenberg

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

iPSC 衍生神经元中的 CRISPR 筛选揭示了 tau 蛋白稳态的原理

Avi J Samelson, Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, Celeste Parra Bravo, Darrin Goodness, Ruilin Tian, Parker Grosjean, Romany Abskharon, David Eisenberg, Nicholas M Kanaan, Li Gan, Carlo Condello, Danielle L Swaney, Martin Kampmann

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils

小分子分解α-突触核蛋白并阻止患者脑源性纤维的播种

Kevin A Murray, Carolyn J Hu, Hope Pan, Jiahui Lu, Romany Abskharon, Jeannette T Bowler, Gregory M Rosenberg, Christopher K Williams, Gazmend Elezi, Melinda Balbirnie, Kym F Faull, Harry V Vinters, Paul M Seidler, David S Eisenberg

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils

基于结构的设计纳米抗体可抑制阿尔茨海默病患者提取的 tau 纤维的播种

Romany Abskharon #, Hope Pan #, Michael R Sawaya, Paul M Seidler, Eileen J Olivares, Yu Chen, Kevin A Murray, Jeffrey Zhang, Carter Lantz, Megan Bentzel, David R Boyer, Duilio Cascio, Binh A Nguyen, Ke Hou, Xinyi Cheng, Els Pardon, Christopher K Williams, Alissa L Nana, Harry V Vinters, Salvatore Sp

Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43

FTLD-TDP 中的淀粉样蛋白原纤维由 TMEM106B 而非 TDP-43 组成

Yi Xiao Jiang #, Qin Cao #, Michael R Sawaya, Romany Abskharon, Peng Ge, Michael DeTure, Dennis W Dickson, Janine Y Fu, Rachel R Ogorzalek Loo, Joseph A Loo, David S Eisenberg

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

RNA 诱导的 tau 纤维的低温电子显微镜结构揭示出一个小的 C 端核心,可能使纤维形成成核

Romany Abskharon, Michael R Sawaya, David R Boyer, Qin Cao, Binh A Nguyen, Duilio Cascio, David S Eisenberg

Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores

由患者提取的纤维接种的 hIAPP 纤维的低温电子显微镜结构揭示了新的多形性和保守的纤维核心

Qin Cao, David R Boyer, Michael R Sawaya, Romany Abskharon, Lorena Saelices, Binh A Nguyen, Jiahui Lu, Kevin A Murray, Fouad Kandeel, David S Eisenberg