日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1

大环碳连接吡唑类化合物作为MCL-1的新型抑制剂

Demin, Samuël; Peschiulli, Aldo; Velter, Adriana I; Vos, Ann; De Boeck, Benoît; Miller, Bradley; Rombouts, Frederik J R; Reuillon, Tristan; Lento, William; Blanco, Maria Dominguez; Jouffroy, Matthieu; Steyvers, Helena; Bekkers, Mariette; Altrocchi, Cristina; Pietrak, Beth; Koo, Seong Joo; Szewczuk, Lawrence; Attar, Ricardo; Philippar, Ulrike

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo

一种能穿透血脑屏障且具有生物利用度的吡唑哌嗪类BACE1抑制剂可在体内持续降低β-淀粉样蛋白水平

Peschiulli, Aldo; Oehlrich, Daniel; Van Gool, Michiel; Austin, Nigel; Van Brandt, Sven; Surkyn, Michel; De Cleyn, Michel; Vos, Ann; Tresadern, Gary; Rombouts, Frederik J R; Macdonald, Gregor J; Moechars, Diederik; Trabanco, Andrés A; Gijsen, Harrie J M

Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats

小分子药物直接鼻腔递送至大脑:基于大鼠标准化体内筛选模型数据的批判性分析

Dhuyvetter, Deborah; Tekle, Fetene; Nazarov, Maxim; Vreeken, Rob J; Borghys, Herman; Rombouts, Frederik; Lenaerts, Ilse; Bottelbergs, Astrid

Clinical evaluation of [(18)F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease

对[(18)F]JNJ-64326067(一种用于检测阿尔茨海默病中tau蛋白病理的新型候选PET示踪剂)进行临床评估

Schmidt, Mark E; Janssens, Luc; Moechars, Diederik; Rombouts, Frederik J R; Timmers, Maarten; Barret, Olivier; Constantinescu, Cristian C; Madonia, Jennifer; Russell, David S; Sandiego, Christine M; Kolb, Hartmuth

In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.

体内抑制RIPK2激酶可缓解炎症性疾病

Tigno-Aranjuez Justine T, Benderitter Pascal, Rombouts Frederik, Deroose Frederik, Bai XiaoDong, Mattioli Benedetta, Cominelli Fabio, Pizarro Theresa T, Hoflack Jan, Abbott Derek W

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.

二氢噻唑并吡啶酮衍生物作为代谢型谷氨酸 5 (mGlu5) 受体的一类新型正向变构调节剂

Bartolomé-Nebreda José Manuel, Conde-Ceide Susana, Delgado Francisca, Iturrino Laura, Pastor Joaquín, Pena Miguel Ángel, Trabanco Andrés A, Tresadern Gary, Wassvik Carola M, Stauffer Shaun R, Jadhav Satyawan, Gogi Kiran, Vinson Paige N, Noetzel Meredith J, Days Emily, Weaver C David, Lindsley Craig W, Niswender Colleen M, Jones Carrie K, Conn P Jeffrey, Rombouts Frederik, Lavreysen Hilde, Macdonald Gregor J, Mackie Claire, Steckler Thomas

Suzuki-Miyaura cross-coupling of potassium dioxolanylethyltrifluoroborate and aryl/heteroaryl chlorides

二氧戊环乙基三氟硼酸钾与芳基/杂芳基氯化物的铃木-宫浦交叉偶联反应

Fleury-Brégeot, Nicolas; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A

Complementary regioselectivity in Rh(III)-catalyzed insertions of potassium vinyltrifluoroborate via C-H activation: preparation and use of 4-trifluoroboratotetrahydroisoquinolones

Rh(III)催化乙烯基三氟硼酸钾通过CH活化插入反应的互补区域选择性:4-三氟硼酸四氢异喹啉酮的制备和应用

Presset, Marc; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A

Synthesis and reactivity of solid-supported organotrifluoroborates in Suzuki cross-coupling

固载有机三氟硼酸酯在铃木交叉偶联反应中的合成与反应性

Colombel, Virginie; Presset, Marc; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A