日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology Analysis

通过微生物组药理学分析鉴定阴道微生物组来源的选择性抗生素代谢物

Jena, Smrutiti; Lawore, Damilola; Briones, Javier Muñoz; Birse, Kenzie; Lamont, Alana; Mackelprang, Romel D; Noel-Romas, Laura; Perner, Michelle; Hou, Xuanlin; Irungu, Elizabeth; Mugo, Nelly; Knodel, Samantha; Brubaker, Stephanie Doran; Muwonge, Timothy R; Katabira, Elly; Hughes, Sean M; Calienes, Fernanda L; Krajci, Raymond; Liu, Rachel; Nemecio, Dalí; Hladik, Florian; Lingappa, Jairam; Burgener, Adam D; Berard, Alicia R; Green, Leopold N; Brubaker, Douglas K

Computational microbiome pharmacology analysis elucidates the anti-cancer potential of vaginal microbes and metabolites

计算微生物组药理学分析阐明了阴道微生物及其代谢物的抗癌潜力

Lawore, Damilola C; Jena, Smrutiti; Berard, Alicia R; Birse, Kenzie; Lamont, Alana; Mackelprang, Romel D; Noel-Romas, Laura; Perner, Michelle; Hou, Xuanlin; Irungu, Elizabeth; Mugo, Nelly; Knodel, Samantha; Muwonge, Timothy R; Katabira, Elly; Hughes, Sean M; Levy, Claire; Calienes, Fernanda L; Hladik, Florian; Lingappa, Jairam R; Burgener, Adam D; Green, Leopold N; Brubaker, Douglas K

Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling

阴道上皮功能障碍由微生物组、代谢组和 mTOR 信号传导介导

Alicia R Berard, Douglas K Brubaker, Kenzie Birse, Alana Lamont, Romel D Mackelprang, Laura Noël-Romas, Michelle Perner, Xuanlin Hou, Elizabeth Irungu, Nelly Mugo, Samantha Knodel, Timothy R Muwonge, Elly Katabira, Sean M Hughes, Claire Levy, Fernanda L Calienes, Douglas A Lauffenburger, Jared M Bae

Upregulation of IFN-stimulated genes persists beyond the transitory broad immunologic changes of acute HIV-1 infection

干扰素刺激基因的上调在急性 HIV-1 感染引起的短暂性广泛免疫学变化后仍然存在

Romel D Mackelprang, Abdelali Filali-Mouhim, Brian Richardson, Francois Lefebvre, Elly Katabira, Allan Ronald, Glenda Gray, Kristen W Cohen, Nichole R Klatt, Tiffany Pecor, Connie Celum, M Juliana McElrath, Sean M Hughes, Florian Hladik, Mark J Cameron, Jairam R Lingappa; Partners in Prevention HSV/

Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection

HIV-1血清转化者感染前PTPRC和干扰素反应通路上调

Li, Yunqi; Lefebvre, Francois; Nakku-Joloba, Edith; Ronald, Allan; Gray, Glenda; de Bruyn, Guy; Kiarie, James; Celum, Connie; Cameron, Mark J; Lingappa, Jairam R; Mackelprang, Romel D

Alloimmunity to Class 2 Human Leucocyte Antigens May Reduce HIV-1 Acquisition - A Nested Case-Control Study in HIV-1 Serodiscordant Couples

对 2 类人类白细胞抗原的同种免疫可能会降低 HIV-1 感染率 - 一项针对 HIV-1 血清不一致夫妇的嵌套病例对照研究

Melinda S Suchard, Neil Martinson, Susan Malfeld, Debbie de Assis Rosa, Romel D Mackelprang, Jairam Lingappa, Xuanlin Hou, Helen Rees, Sinead Delany-Moretlwe, Hadassa Goldfein, Heena Ranchod, David Coetzee, Kennedy Otwombe, Lynn Morris, Caroline T Tiemessen, Dana M Savulescu

Brief Report: Bacterial Vaginosis and Risk of HIV Infection in the Context of CD101 Gene Variation

简报:CD101基因变异背景下的细菌性阴道病与HIV感染风险

Wanga, Valentine; Mackelprang, Romel D; Thomas, Katherine K; Donnell, Deborah; Cohen, Craig R; Mugo, Nelly R; Bukusi, Elizabeth A; de Bruyn, Guy; Irungu, Elizabeth; Celum, Connie; Baeten, Jared M; Lingappa, Jairam R

Correction: Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1

更正:对极端表型进行全基因组测序,发现 CD101 和 UBE2V1 中的变异与性传播 HIV-1 感染风险增加相关。

Mackelprang, Romel D; Bamshad, Michael J; Chong, Jessica X; Hou, Xuanlin; Buckingham, Kati J; Shively, Kathryn; deBruyn, Guy; Mugo, Nelly R; Mullins, James I; McElrath, M Juliana; Baeten, Jared M; Celum, Connie; Emond, Mary J; Lingappa, Jairam R

Schistosomiasis was not associated with higher HIV-1 plasma or genital set point viral loads among HIV seroconverters from four cohort studies

四项队列研究显示,血吸虫病与 HIV 血清转化者血浆或生殖器病毒载量升高无关。

Bochner, Aaron F; Secor, W Evan; Baeten, Jared M; van Dam, Govert J; Szpiro, Adam A; Njenga, Sammy M; Corstjens, Paul L A M; Mackelprang, Romel D; Mugo, Nelly R; Overbaugh, Julie; Celum, Connie; Mujugira, Andrew; McClelland, R Scott; Barnabas, Ruanne V

EPHA2 sequence variants are associated with susceptibility to Kaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma prevalence in HIV-infected patients

EPHA2序列变异与HIV感染患者中卡波西肉瘤相关疱疹病毒感染的易感性和卡波西肉瘤的患病率相关。

Blumenthal, Melissa J; Schutz, Charlotte; Meintjes, Graeme; Mohamed, Zainab; Mendelson, Marc; Ambler, Jon M; Whitby, Denise; Mackelprang, Romel D; Carse, Sinead; Katz, Arieh A; Schäfer, Georgia