日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant.

神经发育过程中由 CHD1L 调控的转录网络紊乱是 1q21.1 拷贝数变异体所表现出的镜像神经解剖学和生长表型的基础。

Lemée Marianne Victoria, Loviglio Maria Nicla, Ye Tao, Tilly Peggy, Keime Céline, Weber Chantal, Petrova Anastasiya, Klein Pernelle, Morlet Bastien, Wendling Olivia, Jacobs Hugues, Tharreau Mylène, Geneviève David, Godin Juliette D, Romier Christophe, Duteil Delphine, Golzio Christelle

ADAT3 variants disrupt the activity of the ADAT tRNA deaminase complex and impair neuronal migration

ADAT3 变体破坏 ADAT tRNA 脱氨酶复合物的活性,并损害神经元迁移。

Del-Pozo-Rodriguez, Jordi; Tilly, Peggy; Lecat, Romain; Vaca, Hugo Rolando; Mosser, Laureline; Brivio, Elena; Balla, Till; Gomes, Marina Vitoria; Ramos-Morales, Elizabeth; Schwaller, Noémie; Salinas-Giegé, Thalia; VanNoy, Grace; England, Eleina M; Kern Lovgren, Alysia; O'Leary, Melanie; Chopra, Maya; Meave Ojeda, Naomi; Toosi, Mehran Beiraghi; Eslahi, Atieh; Alerasool, Masoome; Mojarrad, Majid; Pais, Lynn S; Yeh, Rebecca C; Gable, Dustin L; Hashem, Mais O; Abdulwahab, Firdous; Rakiz Alqurashi, Muath; Sbeih, Loai Z; Adas Blanco, Omar Abu; Khater, Renad Abu; Oprea, Gabriela; Rad, Aboulfazl; Alzaidan, Hamad; Aldhalaan, Hesham; Tous, Ehab; Alsagheir, Afaf; Alowain, Mohammed; Tamim, Abdullah; Alfayez, Khowlah; Alhashem, Amal; Alnuzha, Aisha; Kamel, Mona; Al-Awam, Bashayer S; Elnaggar, Walaa; Almenabawy, Nihal; O'Donnell-Luria, Anne; Neil, Jennifer E; Gleeson, Joseph G; Walsh, Christopher A; Alkuraya, Fowzan S; AlAbdi, Lama; Elkhateeb, Nour; Selim, Laila; Srivastava, Siddharth; Nedialkova, Danny D; Drouard, Laurence; Romier, Christophe; Bayam, Efil; Godin, Juliette D

Benzodeazaoxaflavin Sirtuin Inhibitors Inhibit Schistosoma mansoni Sirt2 and Cause Phenotypic Changes and Lethality in Schistosomula and Adult Worm Stages.

苯并二氮杂黄素 Sirtuin 抑制剂抑制曼氏血吸虫 Sirt2,导致血吸虫幼虫和成虫阶段的表型变化和致死性。

Gimmelli Roberto, Papoff Giuliana, Fabbrizi Emanuele, Guida Michela, Lalli Cristiana, Saccoccia Fulvio, Häberli Cécile, Keiser Jennifer, Monaldi Daria, Jung Manfred, Romier Christophe, Rotili Dante, Mai Antonello, Ruberti Giovina

In cellulo and in vivo assays for compound testing against Trypanosoma cruzi.

细胞内和体内试验,用于测试化合物对克氏锥虫的活性

Guerra-Slompo Eloise Pavão, Picchi-Constante Gisele Fernanda Assine, Marek Martin, Romier Christophe, Sippl Wolfgang, Zanchin Nilson Ivo Tonin

Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors

基于结构的三唑类smHDAC8抑制剂的设计、合成及生物学评价

Kalinin, Dmitrii V; Jana, Sunit K; Pfafenrot, Maxim; Chakrabarti, Alokta; Melesina, Jelena; Shaik, Tajith B; Lancelot, Julien; Pierce, Raymond J; Sippl, Wolfgang; Romier, Christophe; Jung, Manfred; Holl, Ralph

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

具有立体化学多样性的咪唑酮哌嗪帽的HDAC1/6/8亚型选择性抑制剂

Lecointre, Bertrand; Narozny, Remy; Borrello, Maria Teresa; Senger, Johanna; Chakrabarti, Alokta; Jung, Manfred; Marek, Martin; Romier, Christophe; Melesina, Jelena; Sippl, Wolfgang; Bischoff, Laurent; Ganesan, A

Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly

对蛋白质 Snu13p/15.5K 与 Rsa1p/NUFIP 因子之间的相互作用进行表征,并证明其对 snoRNP 组装的功能重要性。

Rothé, Benjamin; Back, Régis; Quinternet, Marc; Bizarro, Jonathan; Robert, Marie-Cécile; Blaud, Magali; Romier, Christophe; Manival, Xavier; Charpentier, Bruno; Bertrand, Edouard; Branlant, Christiane

Baculovirus VP1054 is an acquired cellular PURα, a nucleic acid-binding protein specific for GGN repeats

杆状病毒VP1054是一种获得性细胞PURα,一种特异性结合GGN重复序列的核酸结合蛋白。

Marek, Martin; Romier, Christophe; Galibert, Lionel; Merten, Otto-Wilhelm; van Oers, Monique M

TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.

TFIID TAF6-TAF9 复合物的形成涉及 TAF6 的含 HEAT 重复序列的 C 端结构域,并受 TAF5 蛋白的调节

Scheer Elisabeth, Delbac Frédéric, Tora Laszlo, Moras Dino, Romier Christophe

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26

Iws1/Spt6复合物的结构揭示了一个在TFIIS、Elongin A和Med26中保守的相互作用域。

Diebold, Marie-Laure; Koch, Michael; Loeliger, Erin; Cura, Vincent; Winston, Fred; Cavarelli, Jean; Romier, Christophe