日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineering mtDNA deletions by reconstituting end joining in human mitochondria

通过在人类线粒体中重建末端连接来构建线粒体DNA缺失

Yi Fu ,Max Land ,Tamar Kavlashvili ,Ruobing Cui ,Minsoo Kim ,Emily DeBitetto ,Toby Lieber ,Keun Woo Ryu ,Elim Choi ,Ignas Masilionis ,Rahul Saha ,Meril Takizawa ,Daphne Baker ,Marco Tigano ,Caleb A Lareau ,Ed Reznik ,Roshan Sharma ,Ronan Chaligne ,Craig B Thompson ,Dana Pe'er ,Agnel Sfeir

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

剪接因子突变白血病中由剪接错误产生的新抗原和相应的T细胞受体

Won Jun Kim ,Edie I Crosse ,Emma De Neef ,Inaki Etxeberria ,Erich Y Sabio ,Eric Wang ,Jan Philipp Bewersdorf ,Kuan-Ting Lin ,Sydney X Lu ,Andrea Belleville ,Nina Fox ,Cynthia Castro ,Pu Zhang ,Takeshi Fujino ,Jennifer Lewis ,Jahan Rahman ,Beatrice Zhang ,Jacob H Winick ,Alexander M Lewis ,Robert F Stanley ,Susan DeWolf ,Brigita Meškauskaitė Urben ,Meril Takizawa ,Tobias Krause ,Henrik Molina ,Ronan Chaligne ,Priya Koppikar ,Jeffrey Molldrem ,Mathieu Gigoux ,Taha Merghoub ,Anthony Daniyan ,Smita S Chandran ,Benjamin D Greenbaum ,Christopher A Klebanoff ,Robert K Bradley ,Omar Abdel-Wahab

A RAS(ON) Multi-Selective Inhibitor Combination Therapy Triggers Long-term Tumor Control through Senescence-Associated Tumor-Immune Equilibrium in Pancreatic Ductal Adenocarcinoma

RAS(ON)多选择性抑制剂联合疗法通过衰老相关的肿瘤免疫平衡触发胰腺导管腺癌的长期肿瘤控制

Caroline Broderick # ,Riccardo Mezzadra # ,Exequiel M Sisso ,Felix Mbuga ,Rashi Raghulan ,Almudena Chaves-Perez ,Amanda Kulick ,Lingyan Jiang ,Jingjing Jiang ,Yu-Jui Ho ,Janelle Simon ,Eric Rosiek ,Eric Chan ,Aveline Filliol ,Ronan Chaligne ,Elisa de Stanchina ,Ximo Pechuan-Jorge ,Andrea Schietinger ,Mallika Singh ,Scott W Lowe

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

RAS突变型白血病干细胞导致对维奈托克产生临床耐药性

Junya Sango # ,Saul Carcamo # ,Maria Sirenko # ,Abhishek Maiti # ,Hager Mansour ,Gulay Ulukaya ,Lewis E Tomalin ,Nataly Cruz-Rodriguez ,Tiansu Wang ,Malgorzata Olszewska ,Emmanuel Olivier ,Manon Jaud ,Bettina Nadorp ,Benjamin Kroger ,Feng Hu ,Lewis Silverman ,Stephen S Chung ,Elvin Wagenblast ,Ronan Chaligne ,Ann-Kathrin Eisfeld ,Deniz Demircioglu ,Dan A Landau ,Piro Lito ,Elli Papaemmanuil ,Courtney D DiNardo ,Dan Hasson ,Marina Konopleva ,Eirini P Papapetrou

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

人类克隆造血的单细胞多组学研究表明,DNMT3A R882 突变通过选择性低甲基化扰乱早期祖细胞状态

Anna S Nam # ,Neville Dusaj # ,Franco Izzo # ,Rekha Murali # ,Robert M Myers # ,Tarek H Mouhieddine ,Jesus Sotelo ,Salima Benbarche ,Michael Waarts ,Federico Gaiti ,Sabrin Tahri ,Ross Levine ,Omar Abdel-Wahab ,Lucy A Godley ,Ronan Chaligne ,Irene Ghobrial ,Dan A Landau

Systematic Comparison of Pancreatic Ductal Adenocarcinoma Models Identifies a Conserved Highly Plastic Basal Cell State

胰腺导管腺癌模型的系统比较确定了一种保守的高塑性基底细胞状态

Kenneth L Pitter #, Olivera Grbovic-Huezo #, Simon Joost #, Anupriya Singhal, Melissa Blum, Katherine Wu, Matilda Holm, Alexander Ferrena, Arjun Bhutkar, Anna Hudson, Nicolas Lecomte, Elisa de Stanchina, Ronan Chaligne, Christine A Iacobuzio-Donahue, Dana Pe'er, Tuomas Tammela

Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states

胶质瘤转录细胞状态的表观遗传编码、遗传性和可塑性

Ronan Chaligne #, Federico Gaiti #, Dana Silverbush #, Joshua S Schiffman #, Hannah R Weisman, Lloyd Kluegel, Simon Gritsch, Sunil D Deochand, L Nicolas Gonzalez Castro, Alyssa R Richman, Johanna Klughammer, Tommaso Biancalani, Christoph Muus, Caroline Sheridan, Alicia Alonso, Franco Izzo, Jane Park

Smart-RRBS for single-cell methylome and transcriptome analysis

用于单细胞甲基化组和转录组分析的Smart-RRBS

Hongcang Gu # ,Ayush T Raman # ,Xiaoxue Wang ,Federico Gaiti ,Ronan Chaligne ,Arman W Mohammad ,Aleksandra Arczewska ,Zachary D Smith ,Dan A Landau ,Martin J Aryee ,Alexander Meissner ,Andreas Gnirke

DNA methylation disruption reshapes the hematopoietic differentiation landscape

DNA甲基化破坏重塑造血分化格局

Franco Izzo #, Stanley C Lee #, Asaf Poran, Ronan Chaligne, Federico Gaiti, Baptiste Gross, Rekha R Murali, Sunil D Deochand, Chelston Ang, Philippa Wyndham Jones, Anna S Nam, Kyu-Tae Kim, Steven Kothen-Hill, Rafael C Schulman, Michelle Ki, Priscillia Lhoumaud, Jane A Skok, Aaron D Viny, Ross L Levi

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

转录组基因分型与体细胞突变和细胞身份相关

Anna S Nam #, Kyu-Tae Kim #, Ronan Chaligne #, Franco Izzo, Chelston Ang, Justin Taylor, Robert M Myers, Ghaith Abu-Zeinah, Ryan Brand, Nathaniel D Omans, Alicia Alonso, Caroline Sheridan, Marisa Mariani, Xiaoguang Dai, Eoghan Harrington, Alessandro Pastore, Juan R Cubillos-Ruiz, Wayne Tam, Ronald H