Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

由 rheb 和 KIF5B 失调引起的线粒体自噬缺陷会导致线粒体活性氧 (ROS) 诱导的 nod 样受体 3 (NLRP3) 依赖性促炎反应并加剧脂毒性