日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution

靶向血脑屏障转铁蛋白受体和CD98hc的Fc工程化大分子具有不同的中枢神经系统和外周生物分布。

Nathalie Khoury,Michelle E Pizzo,Claire B Discenza,David Joy,David Tatarakis,Mihail Ivilinov Todorov,Moritz Negwer,Connie Ha,Gabrielly L De Melo,Lily Sarrafha,Matthew J Simon,Darren Chan,Roni Chau,Kylie S Chew,Johann Chow,Allisa Clemens,Yaneth Robles-Colmenares,Jason C Dugas,Joseph Duque,Doris Kaltenecker,Holly Kane,Amy Leung,Edwin Lozano,Arash Moshkforoush,Elysia Roche,Thomas Sandmann,Mabel Tong,Kaitlin Xa,Yinhan Zhou,Joseph W Lewcock,Ali Ertürk,Robert G Thorne,Meredith E K Calvert,Y Joy Yu Zuchero

Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model

在早期发育过程中,血脑屏障处转铁蛋白受体介导的转运水平升高,并在衰老过程中以及阿尔茨海默病小鼠模型中维持稳定。

Vanessa O Torres ,Michelle E Pizzo ,Darren Chan ,Jason C Dugas ,David Huynh ,David Joy ,Eric K Liang ,Lily Sarrafha ,Isabel Becerra ,Roni Chau ,Kylie S Chew ,Johann Chow ,Claire B Discenza ,Timothy K Earr ,Laura Furaso ,Nathalie Khoury ,Kendra J Lechtenberg ,Amy W Leung ,Hoang N Nguyen ,Emmanuel S Ojo ,Elysia Roche ,Matthew J Simon ,Hilda Solanoy ,Mabel Tong ,Raymond K Tong ,Kirk Henne ,Joseph W Lewcock ,Ryan J Watts ,Meredith E Calvert ,Robert G Thorne ,Y Joy Yu Zuchero

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

DNL343 是一种在研的中枢神经系统渗透性真核起始因子 2B 激活剂,可预防和逆转由综合应激反应引起的神经退行性的影响

Ernie Yulyaningsih #, Jung H Suh, Melania Fanok #, Roni Chau, Hilda Solanoy, Ryan Takahashi, Anna I Bakardjiev, Isabel Becerra, N Butch Benitez, Chi-Lu Chiu, Sonnet S Davis, William E Dowdle, Timothy Earr, Anthony A Estrada, Audrey Gill, Connie Ha, Patrick C G Haddick, Kirk R Henne, Martin Larhammar

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

新型应用程序敲入小鼠模型展现了淀粉样蛋白病理的关键特征,并揭示了小胶质细胞严重的代谢紊乱。

Dan Xia # ,Steve Lianoglou # ,Thomas Sandmann ,Meredith Calvert ,Jung H Suh ,Elliot Thomsen ,Jason Dugas ,Michelle E Pizzo ,Sarah L DeVos ,Timothy K Earr ,Chia-Ching Lin ,Sonnet Davis ,Connie Ha ,Amy Wing-Sze Leung ,Hoang Nguyen ,Roni Chau ,Ernie Yulyaningsih ,Isabel Lopez ,Hilda Solanoy ,Shababa T Masoud ,Chun-Chi Liang ,Karin Lin ,Giuseppe Astarita ,Nathalie Khoury ,Joy Yu Zuchero ,Robert G Thorne ,Kevin Shen ,Stephanie Miller ,Jorge J Palop ,Dylan Garceau ,Michael Sasner ,Jennifer D Whitesell ,Julie A Harris ,Selina Hummel ,Johannes Gnörich ,Karin Wind ,Lea Kunze ,Artem Zatcepin ,Matthias Brendel ,Michael Willem ,Christian Haass ,Daniel Barnett ,Till S Zimmer ,Anna G Orr ,Kimberly Scearce-Levie ,Joseph W Lewcock ,Gilbert Di Paolo ,Pascal E Sanchez

Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme

分子结构决定了转铁蛋白受体靶向溶酶体酶的大脑输送

Annie Arguello #, Cathal S Mahon #, Meredith E K Calvert, Darren Chan, Jason C Dugas, Michelle E Pizzo, Elliot R Thomsen, Roni Chau, Lorna A Damo, Joseph Duque, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, Hoang N Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, Julie C Ullman, Junhua Wang, Ma

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

利用可穿透血脑屏障的生物制剂挽救由 Grn 功能丧失引起的溶酶体贮积症

Todd Logan ,Matthew J Simon ,Anil Rana ,Gerald M Cherf ,Ankita Srivastava ,Sonnet S Davis ,Ray Lieh Yoon Low ,Chi-Lu Chiu ,Meng Fang ,Fen Huang ,Akhil Bhalla ,Ceyda Llapashtica ,Rachel Prorok ,Michelle E Pizzo ,Meredith E K Calvert ,Elizabeth W Sun ,Jennifer Hsiao-Nakamoto ,Yashas Rajendra ,Katrina W Lexa ,Devendra B Srivastava ,Bettina van Lengerich ,Junhua Wang ,Yaneth Robles-Colmenares ,Do Jin Kim ,Joseph Duque ,Melina Lenser ,Timothy K Earr ,Hoang Nguyen ,Roni Chau ,Buyankhishig Tsogtbaatar ,Ritesh Ravi ,Lukas L Skuja ,Hilda Solanoy ,Howard J Rosen ,Bradley F Boeve ,Adam L Boxer ,Hilary W Heuer ,Mark S Dennis ,Mihalis S Kariolis ,Kathryn M Monroe ,Laralynne Przybyla ,Pascal E Sanchez ,Rene Meisner ,Dolores Diaz ,Kirk R Henne ,Ryan J Watts ,Anastasia G Henry ,Kannan Gunasekaran ,Giuseppe Astarita ,Jung H Suh ,Joseph W Lewcock ,Sarah L DeVos ,Gilbert Di Paolo