日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells.

宿主来源的白细胞介素-1α通过重编程肿瘤相关髓系细胞来驱动肿瘤免疫抑制。

Keerthi Raja Manikanda Raja, Gupta Gourab, Atkinson Grace, Kathrein Katie, Armstrong Alissa, Gower R Michael, Roninson Igor B, Broude Eugenia V, Chen Mengqian, Ji Hao, Lim Chang-Uk, Wang Hongjun, Fan Daping, Xu Peisheng, Li Jie, Zhou Gang, Chen Hexin

Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 mediator kinase inhibition

CDK8/19介导激酶抑制可以克服卵巢癌的抗凋亡和转移。

Monavarian, Mehri; Rajkarnikar, Resha; Page, Emily Faith; Kumari, Asha; Quintero Macias, Liz; Massicano, Felipe; Lee, Nam Y; Sahoo, Sarthak; Hempel, Nadine; Jolly, Mohit Kumar; Ianov, Lara; Worthey, Elizabeth; Singh, Abhyudai; Roninson, Igor B; Broude, Eugenia V; Chen, Mengqian; Mythreye, Karthikeyan

CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells.

CDK8/19 抑制可减弱 BCR-ABL 拮抗剂诱导的 G1 期阻滞,并加速慢性粒细胞白血病细胞的死亡

Khamidullina Alvina I, Yastrebova Margarita A, Bruter Alexandra V, Nuzhina Julia V, Vorobyeva Nadezhda E, Khrustaleva Anastasia M, Varlamova Ekaterina A, Tyakht Alexander V, Abramenko Iaroslav E, Ivanova Ekaterina S, Zamkova Maria A, Li Jing, Lim Chang-Uk, Chen Mengqian, Broude Eugenia V, Roninson Igor B, Shtil Alexander A, Tatarskiy Victor V

Knockout of cyclin-dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice.

敲除细胞周期蛋白依赖性激酶 8 和 19 会导致细胞周期蛋白 C 耗竭,并抑制小鼠的精子发生和雄性生育能力

Bruter Alexandra V, Varlamova Ekaterina A, Stavskaya Nina I, Antysheva Zoia G, Manskikh Vasily N, Tvorogova Anna V, Korshunova Diana S, Khamidullina Alvina I, Utkina Marina V, Bogdanov Viktor P, Baikova Iuliia P, Nikiforova Alyona I, Albert Eugene A, Maksimov Denis O, Li Jing, Chen Mengqian, Schools Gary P, Feoktistov Alexey V, Shtil Alexander A, Roninson Igor B, Mogila Vladislav A, Silaeva Yulia Y, Tatarskiy Victor V

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

介质激酶抑制剂可逆转晚期前列腺癌的去势抵抗性

Li, Jing; Hilimire, Thomas A; Liu, Yueying; Wang, Lili; Liang, Jiaxin; Gyorffy, Balazs; Sikirzhytski, Vitali; Ji, Hao; Zhang, Li; Cheng, Chen; Ding, Xiaokai; Kerr, Kendall R; Dowling, Charles E; Chumanevich, Alexander A; Mack, Zachary T; Schools, Gary P; Lim, Chang-Uk; Ellis, Leigh; Zi, Xiaolin; Porter, Donald C; Broude, Eugenia V; McInnes, Campbell; Wilding, George; Lilly, Michael B; Roninson, Igor B; Chen, Mengqian

Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors

介导激酶抑制剂可抑制三阴性乳腺癌的生长,并延长mTOR和AKT抑制剂的肿瘤抑制作用。

Ding, Xiaokai; Liang, Jiaxin; Sharko, Amanda C; Hilimire, Thomas A; Li, Jing; Loskutov, Jürgen; Mack, Zachary T; Ji, Hao; Schools, Gary P; Cai, Chao; Pugacheva, Elena N; Chen, Mengqian; Roninson, Igor B; Broude, Eugenia V

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

宿主来源的白细胞介素1α通过调节单核细胞向巨噬细胞的分化诱导免疫抑制性肿瘤微环境。

Raja, Manikanda Raja Keerthi; Gupta, Gourab; Atkinson, Grace; Kathrein, Katie; Armstrong, Alissa; Gower, Michael; Roninson, Igor; Broude, Eugenia; Chen, Menqiang; Ji, Hao; Lim, Changuk; Wang, Hongjun; Fan, Daping; Xu, Peisheng; Li, Jie; Zhou, Gang; Chen, Hexin

Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes.

抑制细胞周期蛋白依赖性激酶 8/19 可限制单核细胞中细菌和病毒诱导的炎症反应

Kokinos Elena K, Tsymbal Sergey A, Galochkina Anastasia V, Bezlepkina Svetlana A, Nikolaeva Julia V, Vershinina Sofia O, Shtro Anna A, Tatarskiy Victor V, Shtil Alexander A, Broude Eugenia V, Roninson Igor B, Dukhinova Marina

Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo

抑制 CDK8/19 介导激酶可增强 HER2 靶向药物的疗效,并在体外和体内克服对这些药物的耐药性。

Ding, Xiaokai; Sharko, Amanda C; McDermott, Martina S J; Schools, Gary P; Chumanevich, Alexander; Ji, Hao; Li, Jing; Zhang, Li; Mack, Zachary T; Sikirzhytski, Vitali; Shtutman, Michael; Ivers, Laura; O'Donovan, Norma; Crown, John; Győrffy, Balázs; Chen, Mengqian; Roninson, Igor B; Broude, Eugenia V

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

一种选择性强、口服生物利用度高的喹啉-6-腈基 CDK8/19 介导激酶抑制剂,具有肿瘤富集药代动力学特征

Zhang, Li; Cheng, Chen; Li, Jing; Wang, Lili; Chumanevich, Alexander A; Porter, Donald C; Mindich, Aleksei; Gorbunova, Svetlana; Roninson, Igor B; Chen, Mengqian; McInnes, Campbell