日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cryo-EM Structure of the Cyclase Domain and Evaluation of Substrate Channeling in a Bifunctional Class II Terpene Synthase

双功能II类萜烯合酶环化酶结构域的冷冻电镜结构及底物通道效应的评估

Gaynes, Matthew N; Schultz, Kollin; Wenger, Eliott S; Ronnebaum, Trey A; Marmorstein, Ronen; Christianson, David W

Structure of the prenyltransferase in bifunctional copalyl diphosphate synthase from Penicillium fellutanum reveals an open hexamer conformation

来自费鲁坦青霉的双功能柯巴利基二磷酸合酶中的异戊二烯基转移酶的结构揭示了一种开放的六聚体构象。

Gaynes, Matthew N; Ronnebaum, Trey A; Schultz, Kollin; Faylo, Jacque L; Marmorstein, Ronen; Christianson, David W

Insight into the Spatial Arrangement of the Lysine Tyrosylquinone and Cu(2+) in the Active Site of Lysyl Oxidase-like 2

对赖氨酰氧化酶样2活性位点中赖氨酸酪氨酰醌和Cu(2+)空间排列的深入研究

Meier, Alex A; Moon, Hee-Jung; Sabuncu, Sinan; Singh, Priya; Ronnebaum, Trey A; Ou, Siyu; Douglas, Justin T; Jackson, Timothy A; Moënne-Loccoz, Pierre; Mure, Minae

Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase N-Dimethylallyl-l-tryptophan Synthase from Fusarium fujikuroi.

镰刀菌属真菌 N-二甲基烯丙基-L-色氨酸合成酶的底物混杂性和催化作用的结构基础

Eaton Samuel A, Ronnebaum Trey A, Roose Benjamin W, Christianson David W

Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD

针对铜绿假单胞菌水杨酸腺苷酸化酶 PchD 的合理抑制剂设计

Shelton, Catherine L; Meneely, Kathleen M; Ronnebaum, Trey A; Chilton, Annemarie S; Riley, Andrew P; Prisinzano, Thomas E; Lamb, Audrey L

Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.

对双功能装配线萜烯合酶的异戊二烯基转移酶结构域进行工程改造

Ronnebaum Trey A, Eaton Samuel A, Brackhahn Emily A E, Christianson David W

An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways

表异异戊二烯合酶活性位点中的芳香簇是萜烯环化途径发散的静电开关

Ronnebaum, Trey A; Gardner, Sarah M; Christianson, David W

Higher-order oligomerization of a chimeric αβγ bifunctional diterpene synthase with prenyltransferase and class II cyclase activities is concentration-dependent.

具有异戊烯基转移酶和 II 类环化酶活性的嵌合 αβγ 双功能二萜合酶的高级寡聚化是浓度依赖性的

Ronnebaum Trey A, Gupta Kushol, Christianson David W

Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-π bond

激活剂结合后,人肝丙酮酸激酶变构位点的变化包括亚基间阳离子-π键的断裂。

McFarlane, Jeffrey S; Ronnebaum, Trey A; Meneely, Kathleen M; Chilton, Annemarie; Fenton, Aron W; Lamb, Audrey L