日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates

优化人源FcRn小鼠模型以改进抗体候选药物的药代动力学评价

Christianson, Gregory; Howard, Zachary M; Kenney, Samantha; Lowell, Emily; Bethur, Nijaguna; Roopenian, Derry; Gonzalo-Gil, Elena

Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment

活化B细胞的葡萄糖氧化依赖性存活为狼疮治疗提供了一个潜在的新治疗靶点。

John J Wilson ,Jian Wei ,Andrea R Daamen ,John D Sears ,Elaine Bechtel ,Colleen L Mayberry ,Grace A Stafford ,Lesley Bechtold ,Amrie C Grammer ,Peter E Lipsky ,Derry C Roopenian ,Chih-Hao Chang

Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice

胶原蛋白 17a1 的功能分析:小鼠交界性大疱性表皮松解症的遗传修饰剂

Thomas J Sproule, Robert Y Wilpan, Benjamin E Low, Kathleen A Silva, Deepak Reyon, J Keith Joung, Michael V Wiles, Derry C Roopenian, John P Sundberg

Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum

交界性大疱性表皮松解症的肌张力障碍调节剂和无肌张力障碍的单纯性大疱性表皮松解症模型

Sproule, Thomas J; Wilpan, Robert Y; Wilson, John J; Low, Benjamin E; Kabata, Yudai; Ushiki, Tatsuo; Abe, Riichiro; Wiles, Michael V; Roopenian, Derry C; Sundberg, John P

FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity

FcRn是CD32a共受体,它决定了对IgG免疫复合物驱动的自身免疫的易感性。

Jonathan J Hubbard ,Michal Pyzik ,Timo Rath ,Lisa K Kozicky ,Kine M K Sand ,Amit K Gandhi ,Algirdas Grevys ,Stian Foss ,Susan C Menzies ,Jonathan N Glickman ,Edda Fiebiger ,Derry C Roopenian ,Inger Sandlie ,Jan Terje Andersen ,Laura M Sly ,Kristi Baker ,Richard S Blumberg

An intact C-terminal end of albumin is required for its long half-life in humans

白蛋白的 C 末端完整,是其在人体中保持较长半衰期的必要条件

Jeannette Nilsen, Esben Trabjerg, Algirdas Grevys, Claudia Azevedo, Stephen O Brennan, Maria Stensland, John Wilson, Kine Marita Knudsen Sand, Malin Bern, Bjørn Dalhus, Derry C Roopenian, Inger Sandlie, Kasper Dyrberg Rand, Jan Terje Andersen

Abrogated AID Function Prolongs Survival and Diminishes Renal Pathology in the BXSB Mouse Model of Systemic Lupus Erythematosus

在系统性红斑狼疮BXSB小鼠模型中,AID功能丧失可延长生存期并减轻肾脏病理。

Jing Zhu ,Alayna N Hay ,Ashley A Potter ,Madison W Richwine ,Thomas Sproule ,Tanya LeRoith ,John Wilson ,Muneer G Hasham ,Derry C Roopenian ,Caroline M Leeth

Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses

阻断人体内的 FcRn 可降低循环 IgG 水平并抑制 IgG 免疫复合物介导的免疫反应

L J Blumberg, J E Humphries, S D Jones, L B Pearce, R Holgate, A Hearn, J Cheung, A Mahmood, B Del Tito, J S Graydon, L E Stolz, A Bitonti, S Purohit, D de Graaf, K Kacena, J T Andersen, G J Christianson, D C Roopenian, J J Hubbard, A K Gandhi, K Lasseter, M Pyzik, R S Blumberg0

Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition

通过抑制 RAD51 增强癌细胞中糖酵解阻断的功效

John J Wilson, Kin-Hoe Chow, Nathan J Labrie, Jane A Branca, Thomas J Sproule, Bryant R A Perkins, Elise E Wolf, Mauro Costa, Grace Stafford, Christine Rosales, Kevin D Mills, Derry C Roopenian, Muneer G Hasham

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

抑制葡萄糖代谢选择性地靶向自身反应性滤泡辅助 T 细胞

Seung-Chul Choi, Anton A Titov, Georges Abboud, Howard R Seay, Todd M Brusko, Derry C Roopenian, Shahram Salek-Ardakani, Laurence Morel