日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of activators for SERCA2a for heart failure treatments

开发用于治疗心力衰竭的SERCA2a激活剂

Brinkmann, Marzena; Wong, Tsung-Yun Kent; Roopnarine, Osha; Yuen, Samantha L; Berg, Kaja; Cornea, Razvan L; Rebbeck, Robyn T; Thomas, David D; Aldrich, Courtney C

A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif

利用FRET检测法监测人β-心肌肌球蛋白的不同结构状态,包括相互作用头部基序。

Goluguri, Rama Reddy; Guhathakurta, Piyali; Nandwani, Neha; Dawood, Aminah; Yokota, Seiji; Roopnarine, Osha; Thomas, David D; Ruppel, Kathleen M; Spudich, James A

Structural Dynamics of Protein Interactions Using Site-Directed Spin Labeling of Cysteines to Measure Distances and Rotational Dynamics with EPR Spectroscopy

利用半胱氨酸位点定向自旋标记结合电子顺磁共振波谱法测量距离和旋转动力学,研究蛋白质相互作用的结构动力学

Roopnarine, Osha; Thomas, David D

A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure.

基于接近原子分辨率结构的FRET检测方法,可定量分析人类β-心肌肌球蛋白相互作用头部基序的水平

Goluguri Rama Reddy, Guhathakurta Piyali, Nandwani Neha, Dawood Aminah, Yakota Seiji, Roopnarine Osha, Thomas David D, Spudich James A, Ruppel Kathleen M

Interaction of DWORF with SERCA and PLB as determined by EPR spectroscopy

通过EPR光谱法测定DWORF与SERCA和PLB的相互作用

Rustad, Mark D; Roopnarine, Osha; Cornea, Razvan L; Thomas, David D

A Large-Scale High-Throughput Screen for Modulators of SERCA Activity

大规模高通量筛选SERCA活性调节剂

Bidwell, Philip A; Yuen, Samantha L; Li, Ji; Berg, Kaja; Rebbeck, Robyn T; Aldrich, Courtney C; Roopnarine, Osha; Cornea, Razvan L; Thomas, David D

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

Mavacamten 可稳定双头心肌肌球蛋白的自身抑制状态

Rohde, John A; Roopnarine, Osha; Thomas, David D; Muretta, Joseph M

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure

肌球蛋白必需轻链的突变导致心肌病,并改变肌动球蛋白结构。

Guhathakurta, Piyali; Prochniewicz, Ewa; Roopnarine, Osha; Rohde, John A; Thomas, David D

An Overview of the Actin-Myosin Interaction

肌动蛋白-肌球蛋白相互作用概述

Thomas, David D; Roopnarine, Osha

Changes in actin and myosin structural dynamics due to their weak and strong interactions

肌动蛋白和肌球蛋白由于弱相互作用和强相互作用而引起的结构动力学变化。

Thomas, David D; Prochniewicz, Ewa; Roopnarine, Osha