日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TYK2 mediates neuroinflammation in Alzheimer's disease brains with TDP-43 pathology

TYK2介导阿尔茨海默病脑组织中TDP-43病理引起的神经炎症

König, Laura E; Rodriguez, Steve; Hug, Clemens; Daneshvari, Shayda; Chung, Alexander; Appleman, Mark; Tsai, Max; Bradshaw, Gary A; Sahin, Asli; Song, Yuyu; Zhou, George; Eisert, Robyn J; Piccioni, Federica; Marques, Christine; Powley, Sharon; Yarmolinsky, James; Wainger, Brian J; Das, Sudeshna; Kalocsay, Marian; Dehghan, Abbas; Tzoulaki, Ioanna; Sokolov, Artem; Sorger, Peter; Root, David E; Albers, Mark W

Morphological map of under- and overexpression of genes in human cells

人类细胞中基因表达不足和过表达的形态学图谱

Chandrasekaran, Srinivas Niranj; Alix, Eric; Arevalo, John; Borowa, Adriana; Byrne, Patrick J; Charles, William G; Chen, Zitong S; Cimini, Beth A; Deng, Boxiong; Doench, John G; Ewald, Jessica D; Fritchman, Briana; Fuller, Colin J; Gaetz, Jedidiah; Goodale, Amy; Haghighi, Marzieh; Han, Yu; Hanifehlou, Zahra; Hennig, Holger; Hernandez, Desiree; Jacob, Christina B; James, Tim; Jetka, Tomasz; Kalinin, Alexandr A; Komalo, Ben; Kost-Alimova, Maria; Krawiec, Tomasz; Marion, Brittany A; Martin, Glynn; McCarthy, Nicola Jane; Miller, Lisa; Monsees, Arne; Moshkov, Nikita; Muñoz, Alán F; Ogier, Arnaud; Otrocka, Magdalena; Rataj, Krzysztof; Root, David E; Rubbo, Francesco; Scrace, Simon; Selinger, Douglas W; Senft, Rebecca A; Sommer, Peter; Thibaudeau, Amandine; Trisorus, Sarah; Valiya Veettil, Rahul; Van Trump, William J; Wang, Sui; Warchoł, Michał; Weisbart, Erin; Weiss, Amélie; Wiest, Michael; Zaremba, Agata; Zinovyev, Andrei; Singh, Shantanu; Carpenter, Anne E

Deep Mutational Scanning of FDX1 Identifies Key Structural Determinants of Lipoylation and Cuproptosis.

对 FDX1 进行深度突变扫描,揭示脂酰化和铜凋亡的关键结构决定因素。

Hsiao Jeffrey C, Warui Douglas M, Kwon Jason J, Dreishpoon Margaret B, Bick Nolan R, Blue-Lahom Tamra, Root David E, Booker Squire J, Tsvetkov Peter

Riboflavin drives nucleotide biosynthesis and iron-sulfur metabolism to promote acute myeloid leukemia

核黄素驱动核苷酸生物合成和铁硫代谢,从而促进急性髓系白血病的发生。

Bjelosevic, Stefan; Fauth, Rahel; Do, Brian T; Alexe, Gabriela; Merickel, Lucy A; Jackson, Thomas D; Basanthakumar, Allen T; Taillon, Audrey; Salhotra, Silvi; Ryback, Birgitta; Schneider, Constanze; DiGiovanni, Giulia; Elbashir, Ryan; Burger, Nils; Bin Munim, Muhammad; Lin, Shan; Puigserver, Pere; Root, David E; Vander Heiden, Matthew G; Stegmaier, Kimberly

A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction.

视紫红质错义转运变异及其对药物纠正的反应的综合图谱

Manian Kannan V, Ludwig Connor H, Zhao Yan, Abell Nathan, Yang Xiaoping, Root David E, Albert Matthew L, Comander Jason

Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents.

染色质扰动促进对低甲基化剂的敏感性

Schneider Constanze, Alexe Gabriela, Merickel Lucy A, Meyer Ashleigh, Swift Michelle L, Serafim Rodolfo B, Basanthakumar Allen T, Taillon Audrey, Salhotra Silvi, Boniolo Fabio, Lambo Sander, Rodriguez Yara, Häupl Björn, George Rani E, Root David E, Oellerich Thomas, Hovestadt Volker, Chowdhury Dipanjan, Stegmaier Kimberly

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

非典型开放阅读框的翻译作为儿童髓母细胞瘤中癌细胞的生存机制

Hofman, Damon A; Ruiz-Orera, Jorge; Yannuzzi, Ian; Murugesan, Rakesh; Brown, Adam; Clauser, Karl R; Condurat, Alexandra L; van Dinter, Jip T; Engels, Sem A G; Goodale, Amy; van der Lugt, Jasper; Abid, Tanaz; Wang, Li; Zhou, Kevin N; Vogelzang, Jayne; Ligon, Keith L; Phoenix, Timothy N; Roth, Jennifer A; Root, David E; Hubner, Norbert; Golub, Todd R; Bandopadhayay, Pratiti; van Heesch, Sebastiaan; Prensner, John R

Author Correction: Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants

作者更正:对 EGFR 进行全面的突变扫描揭示了胞外结构域突变体的 TKI 敏感性

Hayes, Tikvah K; Aquilanti, Elisa; Persky, Nicole S; Yang, Xiaoping; Kim, Erica E; Brenan, Lisa; Goodale, Amy B; Alan, Douglas; Sharpe, Ted; Shue, Robert E; Westlake, Lindsay; Golomb, Lior; Silverman, Brianna R; Morris, Myshal D; Fisher, Ty Running; Beyene, Eden; Li, Yvonne Y; Cherniack, Andrew D; Piccioni, Federica; Hicks, J Kevin; Chi, Andrew S; Cahill, Daniel P; Dietrich, Jorg; Batchelor, Tracy T; Root, David E; Johannessen, Cory M; Meyerson, Matthew

Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries

种系变异会导致基于 CRISPR 的实验出现假阴性结果,且不同种族群体中假阴性结果的发生率各不相同。

Misek, Sean A; Fultineer, Aaron; Kalfon, Jeremie; Noorbakhsh, Javad; Boyle, Isabella; Roy, Priyanka; Dempster, Joshua; Petronio, Lia; Huang, Katherine; Saadat, Alham; Green, Thomas; Brown, Adam; Doench, John G; Root, David E; McFarland, James M; Beroukhim, Rameen; Boehm, Jesse S

CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines

CRISPR-Cas9筛选揭示人类癌细胞系中常见的必需miRNA

Merk, Daniel J; Paul, Linda; Tsiami, Foteini; Hohenthanner, Helen; Kouchesfahani, Ghazal Mohseni; Haeusser, Lara A; Walter, Bianca; Brown, Adam; Persky, Nicole S; Root, David E; Tabatabai, Ghazaleh