日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

μ-阿片受体的正向变构调节可产生镇痛作用,且副作用较少

Kandasamy, Ram; Hillhouse, Todd M; Livingston, Kathryn E; Kochan, Kelsey E; Meurice, Claire; Eans, Shainnel O; Li, Ming-Hua; White, Andrew D; Roques, Bernard P; McLaughlin, Jay P; Ingram, Susan L; Burford, Neil T; Alt, Andrew; Traynor, John R

Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

可卡因会扰乱腹侧苍白球中 GABA 神经传递的阿片类门控机制

Kupchik, Yonatan M; Scofield, Michael D; Rice, Kenner C; Cheng, Kejun; Roques, Bernard P; Kalivas, Peter W

Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.

鉴定内皮素转化酶-2特异性荧光底物,并建立体外和离体酶活性测定方法

Ouimet Tanja, Orng Sou-Vinh, Poras Hervé, Gagnidze Khatuna, Devi Lakshmi A, Fournié-Zaluski Marie-Claude, Roques Bernard P

Sensitization to the conditioned rewarding effects of morphine modulates gene expression in rat hippocampus

对吗啡条件性奖赏效应的敏化会调节大鼠海马中的基因表达

Marie-Claire, Cynthia; Courtin, Cindie; Robert, Amelie; Gidrol, Xavier; Roques, Bernard P; Noble, Florence

The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain

HIV-1 调控蛋白 Vpr 的 C 端结构域通过其亮氨酸拉链样结构域在溶液中形成反平行二聚体结构。

Bourbigot, Sarah; Beltz, Hervé; Denis, Jérôme; Morellet, Nelly; Roques, Bernard P; Mély, Yves; Bouaziz, Serge

Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension.

全身活性氨肽酶 A 抑制剂阻断脑肾素-血管紧张素系统:盐依赖性高血压的潜在治疗方法

Fournie-Zaluski Marie-Claude, Fassot Celine, Valentin Bruno, Djordjijevic Dragan, Reaux-Le Goazigo Annabelle, Corvol Pierre, Roques Bernard P, Llorens-Cortes Catherine

Total direct chemical synthesis and biological activities of human group IIA secretory phospholipase A2

人类IIA组分泌型磷脂酶A2的完全直接化学合成及生物活性

Dong, Chang-Zhi; Romieu, Anthony; Mounier, Carine M; Heymans, Françoise; Roques, Bernard P; Godfroid, Jean-Jacques

Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system

小鼠CCK2受体缺失会导致内源性阿片系统上调。

Pommier, Blandine; Beslot, Françoise; Simon, Axelle; Pophillat, Matthieu; Matsui, Toshimitsu; Dauge, Valérie; Roques, Bernard P; Noble, Florence

Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study

慢性吗啡治疗调节大鼠脑内与阿片类药物依赖相关的结构中内源性脑啡肽的细胞外水平:一项微透析研究

Nieto, Magdalena Mas; Wilson, Jodie; Cupo, Annie; Roques, Bernard P; Noble, Florence