日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo

发现 AVI-6451,一种强效且选择性的 SARS-CoV-2 ADP-核糖水解酶 Mac1 抑制剂,具有体内口服疗效

Jaishankar, Priyadarshini; Correy, Galen J; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M; Stevens, Maisie G V; Hantz, Eric R; Zheng, Jeffrey; Diolaiti, Morgan E; Montano, Mauricio; Taha, Taha Y; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J; Shoichet, Brian K; Ashworth, Alan; Ott, Melanie; Fraser, James S; Renslo, Adam R

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Coupling high-throughput protease enzymology with viral replication reveals biochemical constraints of viral fitness

将高通量蛋白酶酶学与病毒复制相结合,揭示了病毒适应性的生化限制。

Aidlen, Dylan; Vo, William Vinh Thanh; Young, Nicholas J; Rosecrans, Julia; Kurianowicz, Anna; Chuo, Shih-Wei; Asper, Garrison P R; Anderson, Dashiell; Posner, Jacob A; Muir, Duncan F; Freitas, Nicholas; Ott, Melanie; Craik, Charles S; Taha, Taha Y; Pinney, Margaux M

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

SARS-CoV-2 Omicron XEC 中的非刺突蛋白核衣壳 R204P 突变会增强炎症反应和致病性。

Tsujino, Shuhei; Tsuda, Masumi; Deguchi, Sayaka; Ito, Jumpei; Taha, Taha Y; Nasser, Hesham; Wang, Lei; Rosecrans, Julia; Suzuki, Rigel; Suzuki, Saori; Yoshimatsu, Kumiko; Ott, Melanie; Ikeda, Terumasa; Sato, Kei; Takayama, Kazuo; Tanaka, Shinya; Tamura, Tomokazu; Fukuhara, Takasuke

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

携带 NSP6 中 L260F 突变的近期 SARS-CoV-2 变种增强了 RNA 复制和致病性

Taha Taha Y, Ezzatpour Shahrzad, Hayashi Jennifer M, Ye Chengjin, Zapatero-Belinchón Francisco J, Rosecrans Julia A, Kimmerly Gabriella R, Chen Irene P, Walcott Keith, Kurianowicz Anna, Jorgens Danielle M, Chaplin Natalie R, Choi Annette, Buchholz David W, Sahler Julie, Hilt Zachary T, Imbiakha Brian, Vagi-Szmola Cecilia, Montano Mauricio, Stevenson Erica, Gordon Martin, Swaney Danielle L, Krogan Nevan J, Whittaker Gary R, Martinez-Sobrido Luis, Aguilar Hector C, Ott Melanie

Torsional twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

SARS-CoV 和 SARS-CoV-2 SUD-N 和 SUD-M 结构域的扭转

Monica Rosas-Lemus, George Minasov, Joseph S Brunzelle, Taha Y Taha, Sofia Lemak, Shaohui Yin, Ludmilla Shuvalova, Julia Rosecrans, Kanika Khanna, H Steven Seifert, Alexei Savchenko, Peter J Stogios, Melanie Ott, Karla J F Satchell

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo

发现 AVI-6451,一种强效且选择性的 SARS-CoV-2 ADP-核糖水解酶 Mac1 抑制剂,具有口服体内疗效。

Jaishankar, Priyadarshini; Correy, Galen J; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M; Stevens, Maisie G V; Hantz, Eric R; Zheng, Jeffrey; Diolaiti, Morgan E; Montano, Mauricio; Taha, Taha Y; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J; Shoichet, Brian K; Ashworth, Alan; Ott, Melanie; Fraser, James S; Renslo, Adam R

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity.

SARS-CoV-2 Omicron XEC 中的非刺突核衣壳 R204P 突变会增强炎症和致病性

Tsujino Shuhei, Tsuda Masumi, Ito Jumpei, Deguchi Sayaka, Taha Taha Y, Nasser Hesham, Wang Lei, Rosecrans Julia, Suzuki Rigel, Suzuki Saori, Yoshimatsu Kumiko, Ott Melanie, Ikeda Terumasa, Takayama Kazuo, Sato Kei, Tanaka Shinya, Tamura Tomokazu, Fukuhara Takasuke