日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

PTEN 和 PIK3CA 的共存改变会过度激活子宫内膜癌中的 mTORC1 信号通路,并导致其对 mTORC1 抑制剂的选择性敏感性。

Solomon, Hilla; Mukherjee, Radha; Yang, Yu Chi; Meredith, Julia; Schram, Alison M; Yi, Sang Ah; Chen, Xiaoping; Tribuzio, Michael; Gundlapalli, Harika; Meyerowitz, Justin; de Stanchina, Elisa; Weigelt, Britta; An, Heeseon; Barry, Simon T; Smith, Jacqueline A M; Singh, Mallika; Rosen, Neal

Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.

直接抑制 RAS 揭示了由 RAS G12 和 Q61 突变驱动的致癌信号的特征

Marasco Michelangelo, Kumar Dinesh, Garcia Borrego Santiago, Seale Tessa, Maddalena Giulia, Mezzadra Riccardo, Belanger Kylie, Cole Soren, Perez Brayan, Luan Wei, Mukherjee Radha, Aricescu Ilinca, Markov Vladimir, Zhu Yuxin, Arena Sabrina, Bardelli Alberto, de Stanchina Elisa, Lowe Scott W, Burkhart Richard A, Zimmerman Jacquelyn W, Yaeger Rona, Kopetz Scott E, Rosen Neal, Misale Sandra

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration.

BRAFV600E 驱动的肿瘤发生需要继发突变来克服其对 RAC1 和迁移的反馈抑制

Gadal Sunyana, Boyer Jacob A, Roy Simon F, Outmezguine Noah A, Sharma Malvika, Li Hongyan, Fan Ning, Chan Eric, Romin Yevgeniy, Barlas Afsar, Chang Qing, Pancholi Priya, Timaul Neilawattie Merna, Overholtzer Michael, Yaeger Rona, Manova-Todorova Katia, de Stanchina Elisa, Bosenberg Marcus W, Rosen Neal

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer.

eIF4A 控制雌激素受体 α 的翻译,是晚期乳腺癌的治疗靶点

Boyer Jacob A, Rosen Ezra Y, Sharma Malvika, Dorso Madeline A, Mai Nicholas, Amor Corina, Reiter Jason M, Kannan Ram, Gadal Sunyana, Xu Jianing, Miele Matthew, Li Zhuoning, Chen Xiaoping, Chang Qing, Pareja Fresia, Worland Stephan, Warner Douglas, Sperry Sam, Chiang Gary G, Thompson Peggy A, Yang Guangli, Ouerfelli Ouathek, Drilon Alexander, de Stanchina Elisa, Wendel Hans-Guido, Chandarlapaty Sarat, Rosen Neal

Diet induced insulin resistance is due to induction of PTEN expression

饮食诱导的胰岛素抵抗是由于PTEN表达的诱导所致。

Mukherjee, Radha; Pancholi, Priya; Sharma, Malvika; Solomon, Hilla; Timaul, Merna N; Thant, Claire; McGriskin, Rory; Hayatt, Omar; Markov, Vladimir; D'Allara, John; Bekker, Simona; Candelier, Jacqueline; Carrasco, Sebastian E; de Stanchina, Elisa; Vanaja, Kiran; Rosen, Neal

Targeting mTORC1 to promote ferroptosis and apoptosis in endometrial cancer with PI3K-Akt-mTOR pathway mutation

靶向 mTORC1 可促进 PI3K-Akt-mTOR 通路突变子宫内膜癌细胞的铁死亡和凋亡

Hu, Yingying; Liu, Pei; Rosen, Neal; Jiang, Xuejun

Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer.

配对的原发转移患者来源的类器官和鼠模型揭示了阑尾癌腹膜转移的表型演变和药物依赖性

Mahmoud Ahmed, Choi Philip H, Sukhwa Christine, Pintar Jura, Walch Henry, Zhao Nan, Bermeo Jonathan, Chung Sebastian, Raghavan Manisha, Bapat Samhita, Jiang Qingwen, Karagkounis Georgios, Meredith Julia, Giarrizzo Michael, Firat Canan, Cercek Andrea, Foote Michael B, Schultz Nikolaus, Chatila Walid K, Nash Garrett M, Shia Jinru, Sanchez-Vega Francisco, Larson Steven, Dar Arvin C, Rosen Neal, Ganesh Karuna

BRAF - a tumour-agnostic drug target with lineage-specific dependencies

BRAF——一种不依赖于特定肿瘤类型的药物靶点,但具有谱系特异性依赖性。

Hanrahan, Aphrothiti J; Chen, Ziyu; Rosen, Neal; Solit, David B

Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets

BRAF融合基因的肿瘤非特异性基因组和临床分析可识别可操作的靶点

Chen, Monica F; Yang, Soo-Ryum; Tao, Jessica J; Desilets, Antoine; Diamond, Eli L; Wilhelm, Clare; Rosen, Ezra; Gong, Yixiao; Mullaney, Kerry; Torrisi, Jean; Young, Robert J; Somwar, Romel; Yu, Helena A; Kris, Mark G; Riely, Gregory J; Arcila, Maria E; Ladanyi, Marc; Donoghue, Mark T A; Rosen, Neal; Yaeger, Rona; Drilon, Alexander; Murciano-Goroff, Yonina R; Offin, Michael

Diet induced insulin resistance is due to induction of PTEN expression

饮食诱导的胰岛素抵抗是由于PTEN表达的诱导所致。

Rosen, Neal; Mukherjee, Radha; Pancholi, Priya; Sharma, Malvika; Solomon, Hilla; Timaul, Merna; Thant, Claire; McGriskin, Rory; Hayatt, Omar; Markov, Vladimir; D'Allara, John; Bekker, Simona; Candelier, Jacqueline; Carrasco, Sebastian; de Stanchina, Elisa; Vanaja, Kiran