日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap-Insig interaction and SREBP activation

Scap 上的跨膜螺旋与膜胆固醇之间的竞争调节 Scap-Insig 相互作用和 SREBP 激活。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2525043123
Williams, Blake C; Kober, Daniel L; Bai, Xiao-Chen; Rosenbaum, Daniel M; Radhakrishnan, Arun
EBP
代谢
发表日期：2026
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Structural mechanism of CB(1)R binding to peripheral and biased inverse agonists

CB(1)R 与外周和偏向性反向激动剂结合的结构机制

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-024-54206-0
Kumari, Punita; Dvorácskó, Szabolcs; Enos, Michael D; Ramesh, Karthik; Lim, Darrix; Hassan, Sergio A; Kunos, George; Cinar, Resat; Iyer, Malliga R; Rosenbaum, Daniel M
发表日期：2024
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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK-925 and ARN-776 in narcoleptic orexin/tTA; TetO-DTA mice

评估下丘脑泌素/食欲素受体激动剂 TAK-925 和 ARN-776 对嗜睡症 orexin/tTA；TetO-DTA 小鼠的疗效

期刊:Journal of Sleep Research
影响因子:3.9
doi:10.1111/jsr.13839
Sun, Yu; Ranjan, Alok; Tisdale, Ryan; Ma, Shun-Chieh; Park, Sunmee; Haire, Meghan; Heu, Jasmine; Morairty, Stephen R; Wang, Xiaoyu; Rosenbaum, Daniel M; Williams, Noelle S; De Brabander, Jef K; Kilduff, Thomas S
信号转导
神经科学
免疫/内分泌
发表日期：2023
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Structure-based development of a subtype-selective orexin 1 receptor antagonist

基于结构的亚型选择性食欲素1受体拮抗剂的开发

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2002704117
Hellmann, Jan; Drabek, Matthäus; Yin, Jie; Gunera, Jakub; Pröll, Theresa; Kraus, Frank; Langmead, Christopher J; Hübner, Harald; Weikert, Dorothee; Kolb, Peter; Rosenbaum, Daniel M; Gmeiner, Peter
信号转导
发表日期：2020
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Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis

SREBP2羧基末端降解信号的鉴定：该结构域在胆固醇稳态中的新作用

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2018578117
Kober, Daniel L; Xu, Shimeng; Li, Shili; Bajaj, Bilkish; Liang, Guosheng; Rosenbaum, Daniel M; Radhakrishnan, Arun
信号转导
EBP
代谢
发表日期：2020
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Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics

利用同位素标记真核生物膜蛋白进行核磁共振研究其相互作用和动力学

期刊:Methods in Enzymology
影响因子:
doi:10.1016/bs.mie.2018.08.030
Dikiy, Igor; Clark, Lindsay D; Gardner, Kevin H; Rosenbaum, Daniel M
微生物学
发表日期：2019
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The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits

脯氨酰4-羟化酶抑制剂GSK360A可减轻中风后脑损伤以及感觉、运动和认知行为缺陷。

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0184049
Zhou, Jin; Li, Jie; Rosenbaum, Daniel M; Zhuang, Jian; Poon, Carrie; Qin, Pu; Rivera, Katrina; Lepore, John; Willette, Robert N; Hu, Erding; Barone, Frank C
中风
GSK3
心血管
神经科学
发表日期：2017
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High-resolution crystal structure of the human CB1 cannabinoid receptor.

人类 CB1 大麻素受体的高分辨率晶体结构

期刊:Nature
影响因子:48.5
doi:10.1038/nature20613
Shao Zhenhua, Yin Jie, Chapman Karen, Grzemska Magdalena, Clark Lindsay, Wang Junmei, Rosenbaum Daniel M
Human
发表日期：2016
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Structure and function of an irreversible agonist-β(2) adrenoceptor complex

不可逆激动剂-β(2)肾上腺素受体复合物的结构和功能

期刊:Nature
影响因子:48.5
doi:10.1038/nature09665
Rosenbaum, Daniel M; Zhang, Cheng; Lyons, Joseph A; Holl, Ralph; Aragao, David; Arlow, Daniel H; Rasmussen, Søren G F; Choi, Hee-Jung; Devree, Brian T; Sunahara, Roger K; Chae, Pil Seok; Gellman, Samuel H; Dror, Ron O; Shaw, David E; Weis, William I; Caffrey, Martin; Gmeiner, Peter; Kobilka, Brian K
信号转导
免疫/内分泌
发表日期：2011
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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.

纳米抗体稳定的β(2)肾上腺素受体活性状态的结构

期刊:Nature
影响因子:48.5
doi:10.1038/nature09648
Rasmussen Søren G F, Choi Hee-Jung, Fung Juan Jose, Pardon Els, Casarosa Paola, Chae Pil Seok, Devree Brian T, Rosenbaum Daniel M, Thian Foon Sun, Kobilka Tong Sun, Schnapp Andreas, Konetzki Ingo, Sunahara Roger K, Gellman Samuel H, Pautsch Alexander, Steyaert Jan, Weis William I, Kobilka Brian K
免疫/内分泌
发表日期：2011
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