日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer's disease

利用 CRISPRi 技术在培养的人类星形胶质细胞中进行筛选,揭示了控制阿尔茨海默病中基因表达失调的远端增强子。

Green, Nicole F O; Sutton, Gavin J; Pérez-Burillo, Javier; Wang, Juli; Bagot, Samuel; Danon, Hannah G; Walsh, Kieran; Gokool, Akira; Miles, Samantha A; Yang, Guang; Herring, Charles A; Liang, Yuheng; Pfundstein, Grant; Sytnyk, Vladimir; Alinejad-Rokny, Hamid; Lister, Ryan; Rosenbluh, Joseph; Gagnon-Bartsch, Johann A; Voineagu, Irina

CRISPR screens identify PRMT7 as a therapeutic target to enhance T cell-mediated killing in breast cancer.

CRISPR 筛选发现 PRMT7 是一个治疗靶点,可以增强 T 细胞介导的乳腺癌杀伤作用。

Shi Wei, Luo Yi, Wang Yizhuo, Burrows Jacqueline M, Black Debra, Civitarese Andrew, Perlaza-Jimenez Laura, Zhang Ping, Manning Murray, Tuano Natasha, Rentería Miguel E, Xiao Christos, Tey Siok-Keen, Rosenbluh Joseph, Smith Corey, Chenevix-Trench Georgia, Beesley Jonathan

A basic framework to explain splice-site choice in eukaryotes

解释真核生物剪接位点选择的基本框架

Dent, Craig I; Prodic, Stefan; Balakrishnan, Aiswarya; Chhabra, Aaryan; Georges, James D G; Mukherjee, Sourav; Coutts, Jordyn; Gitonobel, Michael; Sarwade, Rucha D; Rosenbluh, Joseph; D'Amato, Mauro; Das, Partha P; Guo, Ya-Long; Fournier-Level, Alexandre; Burke, Richard; Sureshkumar, Sridevi; Powell, David; Balasubramanian, Sureshkumar

SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss.

SRP19 和蛋白质分泌机制是 APC 缺失的癌症中可靶向的脆弱点

Xi Xinqi, Liu Ling, Tuano Natasha, Tailhades Julien, Mouradov Dmitri, Steen Jason, Sieber Oliver, Cryle Max, Nguyen-Dumont Tu, Segelov Eva, Rosenbluh Joseph

SAM-DNMT3A, a strategy for induction of genome-wide DNA methylation, identifies DNA methylation as a vulnerability in ER-positive breast cancers.

SAM-DNMT3A 是一种诱导全基因组 DNA 甲基化的策略,它发现 DNA 甲基化是 ER 阳性乳腺癌的一个弱点

Hosseinpour Mahnaz, Xi Xinqi, Liu Ling, Malaver-Ortega Luis, Perlaza-Jimenez Laura, Joo Jihoon E, York Harrison M, Beesley Jonathan, Caldon C Elizabeth, Dugué Pierre-Antoine, Dowty James G, Arumugam Senthil, Southey Melissa C, Rosenbluh Joseph

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

鉴定对 TEAD 调节转录的小分子抑制的抗性机制

Aishwarya Kulkarni, Varshini Mohan, Tracy T Tang, Leonard Post, Yih-Chih Chan, Murray Manning, Niko Thio, Benjamin L Parker, Mark A Dawson, Joseph Rosenbluh, Joseph Ha Vissers, Kieran F Harvey0

Technological Convergence: Highlighting the Power of CRISPR Single-Cell Perturbation Toolkit for Functional Interrogation of Enhancers

技术融合:凸显 CRISPR 单细胞扰动工具包在增强子功能研究中的强大作用

Ghamsari, Reza; Rosenbluh, Joseph; Menon, A Vipin; Lovell, Nigel H; Alinejad-Rokny, Hamid

Heritable methylation marks associated with prostate cancer risk

与前列腺癌风险相关的遗传性甲基化标记

Dowty, James G; Yu, Chenglong; Hosseinpour, Mahnaz; Joo, Jihoon Eric; Wong, Ee Ming; Nguyen-Dumont, Tu; Rosenbluh, Joseph; Giles, Graham G; Milne, Roger L; MacInnis, Robert J; Dugué, Pierre-Antoine; Southey, Melissa C

Author Correction: CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

作者更正:CRISPRi 能够进行同工型特异性功能缺失筛选,并识别胃癌特异性同工型依赖性。

Davies, Rebecca; Liu, Ling; Taotao, Sheng; Tuano, Natasha; Chaturvedi, Richa; Huang, Kie Kyon; Itman, Catherine; Mandoli, Amit; Qamra, Aditi; Hu, Changyuan; Powell, David; Daly, Roger J; Tan, Patrick; Rosenbluh, Joseph

GeNets: a unified web platform for network-based genomic analyses

GeNets:一个用于基于网络的基因组分析的统一网络平台

Li, Taibo; Kim, April; Rosenbluh, Joseph; Horn, Heiko; Greenfeld, Liraz; An, David; Zimmer, Andrew; Liberzon, Arthur; Bistline, Jon; Natoli, Ted; Li, Yang; Tsherniak, Aviad; Narayan, Rajiv; Subramanian, Aravind; Liefeld, Ted; Wong, Bang; Thompson, Dawn; Calvo, Sarah; Carr, Steve; Boehm, Jesse; Jaffe, Jake; Mesirov, Jill; Hacohen, Nir; Regev, Aviv; Lage, Kasper