日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Understanding heterogeneity in the pathogenesis and drug responses of ulcerative colitis through single-cell and spatial transcriptomics

通过单细胞和空间转录组学了解溃疡性结肠炎发病机制和药物反应的异质性

Phillips, Jennifer; Tambakis, George; Kumar, Rina; Croft, Anthony; Brown, Ian; Rosty, Christophe; Anderson, Robert; Belz, Gabrielle; Oliver, Amanda J; Xiong, Albert; Nguyen, Quan; Radford-Smith, Graham; Walker, Gareth J

Germline MLH1 c.-42 C > T is a likely pathogenic variant predisposing to a reduced-penetrance/modified Lynch syndrome phenotype featuring MLH1-methylated cancers

生殖系 MLH1 c.-42 C > T 是一种可能致病的变异,易导致低外显率/改良型林奇综合征表型,其特征是 MLH1 甲基化癌症。

Buchanan, Daniel D; Alvarez, Rocio; Mahmood, Khalid; Clendenning, Mark; Georgeson, Peter; Walker, Romy; Como, Julia; Preston, Susan G; Joseland, Sharelle; Mohammadsaeedi, Kimia; Aguirre, Francesca; Zhou, Lisa; Hazelett, Dennis J; Jenkins, Mark A; Rosty, Christophe; Winship, Ingrid M; Macrae, Finlay A; Dwarte, Tanya M; Nixon, Dawn; Hitchins, Megan P; Joo, Jihoon E

Intratumoural pks(+)Escherichia coli is associated with risk of metachronous colorectal cancer and adenoma development in people with Lynch syndrome

肿瘤内PKS阳性大肠杆菌与林奇综合征患者发生异时性结直肠癌和腺瘤的风险相关。

Chu, Yen Lin; Georgeson, Peter; Clendenning, Mark; Mahmood, Khalid; Walker, Romy; Como, Julia; Joseland, Sharelle; Preston, Susan G; Rice, Toni; Lynch, Brigid M; Milne, Roger L; Southey, Melissa C; Giles, Graham G; Phipps, Amanda I; Hopper, John L; Win, Aung K; Rosty, Christophe; Macrae, Finlay A; Winship, Ingrid; Jenkins, Mark A; Buchanan, Daniel D; Joo, Jihoon E

Intratumoral presence of the genotoxic gut bacteria pks(+) E. coli, Enterotoxigenic Bacteroides fragilis, and Fusobacterium nucleatum and their association with clinicopathological and molecular features of colorectal cancer

肿瘤内致病性肠道细菌 pks(+) 大肠杆菌、肠毒素性脆弱拟杆菌和具核梭杆菌的存在及其与结直肠癌临床病理及分子特征的关联

Joo, Jihoon E; Chu, Yen Lin; Georgeson, Peter; Walker, Romy; Mahmood, Khalid; Clendenning, Mark; Meyers, Aaron L; Como, Julia; Joseland, Sharelle; Preston, Susan G; Diepenhorst, Natalie; Toner, Julie; Ingle, Danielle J; Sherry, Norelle L; Metz, Andrew; Lynch, Brigid M; Milne, Roger L; Southey, Melissa C; Hopper, John L; Win, Aung Ko; Macrae, Finlay A; Winship, Ingrid M; Rosty, Christophe; Jenkins, Mark A; Buchanan, Daniel D

Associations between pathological features and risk of metachronous colorectal cancer

病理特征与异时性结直肠癌风险之间的关联

Zhang, Ye; Win, Aung Ko; Makalic, Enes; Buchanan, Daniel D; Pai, Rish K; Phipps, Amanda I; Rosty, Christophe; Boussioutas, Alex; Karahalios, Amalia; Jenkins, Mark A

Inherited BRCA1 and RNF43 pathogenic variants in a familial colorectal cancer type X family

家族性X型结直肠癌家族中遗传的BRCA1和RNF43致病变异

Chan, James M; Clendenning, Mark; Joseland, Sharelle; Georgeson, Peter; Mahmood, Khalid; Joo, Jihoon E; Walker, Romy; Como, Julia; Preston, Susan; Chai, Shuyi Marci; Chu, Yen Lin; Meyers, Aaron L; Pope, Bernard J; Duggan, David; Fink, J Lynn; Macrae, Finlay A; Rosty, Christophe; Winship, Ingrid M; Jenkins, Mark A; Buchanan, Daniel D

The first case of combined pancreatic neuroendocrine tumour and neuroendocrine carcinoma

首例胰腺神经内分泌肿瘤合并神经内分泌癌的病例

Lun, Tegan; Rosty, Christophe; Palamuthusingam, Pranavan

Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival

结直肠癌中基因毒性大肠杆菌素突变特征与临床病理特征、特定基因组改变和更好的生存率相关。

Georgeson, Peter; Steinfelder, Robert S; Harrison, Tabitha A; Pope, Bernard J; Zaidi, Syed H; Qu, Conghui; Lin, Yi; Joo, Jihoon E; Mahmood, Khalid; Clendenning, Mark; Walker, Romy; Aglago, Elom K; Berndt, Sonja I; Brenner, Hermann; Campbell, Peter T; Cao, Yin; Chan, Andrew T; Chang-Claude, Jenny; Dimou, Niki; Doheny, Kimberly F; Drew, David A; Figueiredo, Jane C; French, Amy J; Gallinger, Steven; Giannakis, Marios; Giles, Graham G; Goode, Ellen L; Gruber, Stephen B; Gsur, Andrea; Gunter, Marc J; Harlid, Sophia; Hoffmeister, Michael; Hsu, Li; Huang, Wen-Yi; Huyghe, Jeroen R; Manson, JoAnn E; Moreno, Victor; Murphy, Neil; Nassir, Rami; Newton, Christina C; Nowak, Jonathan A; Obón-Santacana, Mireia; Ogino, Shuji; Pai, Rish K; Papadimitrou, Nikos; Potter, John D; Schoen, Robert E; Song, Mingyang; Sun, Wei; Toland, Amanda E; Trinh, Quang M; Tsilidis, Kostas; Ugai, Tomotaka; Um, Caroline Y; Macrae, Finlay A; Rosty, Christophe; Hudson, Thomas J; Winship, Ingrid M; Phipps, Amanda I; Jenkins, Mark A; Peters, Ulrike; Buchanan, Daniel D

DNA Mismatch Repair Gene Variant Classification: Evaluating the Utility of Somatic Mutations and Mismatch Repair Deficient Colonic Crypts and Endometrial Glands

DNA错配修复基因变异分类:评估体细胞突变和错配修复缺陷在结肠隐窝和子宫内膜腺体中的应用价值

Walker, Romy; Mahmood, Khalid; Como, Julia; Clendenning, Mark; Joo, Jihoon E; Georgeson, Peter; Joseland, Sharelle; Preston, Susan G; Pope, Bernard J; Chan, James M; Austin, Rachel; Bojadzieva, Jasmina; Campbell, Ainsley; Edwards, Emma; Gleeson, Margaret; Goodwin, Annabel; Harris, Marion T; Ip, Emilia; Kirk, Judy; Mansour, Julia; Mar Fan, Helen; Nichols, Cassandra; Pachter, Nicholas; Ragunathan, Abiramy; Spigelman, Allan; Susman, Rachel; Christie, Michael; Jenkins, Mark A; Pai, Rish K; Rosty, Christophe; Macrae, Finlay A; Winship, Ingrid M; Buchanan, Daniel D

Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers

利用液滴数字PCR和全基因组DNA甲基化谱分析结直肠癌,鉴定出具有低水平MLH1体细胞甲基化的原发性和继发性MLH1表观突变携带者

Joo, Jihoon E; Mahmood, Khalid; Walker, Romy; Georgeson, Peter; Candiloro, Ida; Clendenning, Mark; Como, Julia; Joseland, Sharelle; Preston, Susan; Graversen, Lise; Wilding, Mathilda; Field, Michael; Lemon, Michelle; Wakeling, Janette; Marfan, Helen; Susman, Rachel; Isbister, Joanne; Edwards, Emma; Bowman, Michelle; Kirk, Judy; Ip, Emilia; McKay, Lynne; Antill, Yoland; Hopper, John L; Boussioutas, Alex; Macrae, Finlay A; Dobrovic, Alexander; Jenkins, Mark A; Rosty, Christophe; Winship, Ingrid M; Buchanan, Daniel D