日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma

PARP14抑制剂联合PD-1阻断可促进复发性黑色素瘤中细胞毒性T细胞的静止状态并调节巨噬细胞极化。

Rotem Leshem # ,Kieran Neil Sefton # ,Chun Wai Wong ,I-Hsuan Lin ,Dervla Tamara Isaac ,Mario Niepel ,Adam Hurlstone

PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models

在临床前癌症模型中,PARP14抑制可恢复IFNγ驱动的获得性耐药后对PD-1免疫检查点抑制剂的反应。

Chun Wai Wong ,Christos Evangelou ,Kieran N Sefton # ,Rotem Leshem # ,Wei Zhang ,Vishaka Gopalan ,Sorayut Chattrakarn ,Macarena Lucia Fernandez Carro ,Erez Uzuner ,Holly Mole ,Daniel J Wilcock ,Michael P Smith ,Kleita Sergiou ,Brian A Telfer ,Dervla T Isaac ,Chang Liu ,Nicholas R Perl ,Kerrie Marie ,Paul Lorigan ,Kaye J Williams ,Patricia E Rao ,Raghavendar T Nagaraju ,Mario Niepel ,Adam F L Hurlstone