日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly specific intracellular ubiquitination of a small molecule.

小分子的高度特异性细胞内泛素化。

Li Weicheng, Garcia-Rivera Enrique M, Mitchell Dylan C, Chick Joel M, Maetani Micah, Bhadoria Rohit, Knapp John M, Misu Ryosuke, Matthews Geoffrey M, Shirasaki Ryosuke, de Matos Simoes Ricardo, Viswanathan Vasanthi, Pulice John L, Rees Matthew G, Roth Jennifer A, Gygi Steven P, Mitsiades Constantine S, Kadoch Cigall, Schreiber Stuart L, Ostrem Jonathan M L

Proximity-Induced Rewiring of Oncogenic Kinase Triggers Apoptosis

邻近诱导的致癌激酶重编程触发细胞凋亡

Merz, Manuel L; Shoba, Veronika M; Pergu, Rajaiah; Severance, Zachary C; Munkanatta Godage, Dhanushka N P; Deb, Arghya; Kwok, Hui Si; Singh, Prashant; Singh, Sameek; Allen, Jonathan B; Tian, Wenzhi; Gosavi, Pallavi M; Chaudhary, Santosh K; Anokhina, Viktoriya; Weisberg, Ellen L; Payne, N Connor; He, Yao; Dhaliwal, Rohil; Osadchey, Reilly; Shekhar, Mrinal; Mazitschek, Ralph; Rees, Matthew G; Roth, Jennifer A; Cui, Qiang; Griffin, James D; Liau, Brian B; Choudhary, Amit

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

PI3Kα抑制剂和降解剂Inavolisib可利用FGFR2增强PIK3CA突变实体瘤患者和临床前模型的疗效。

Juric Dejan, Song Kyung, Johnson Radia M, Accordino Melissa K, Bedard Philippe L, Cervantes Andrés, Gambardella Valentina, Hamilton Erika, Italiano Antoine, Kalinsky Kevin, Krop Ian E, Oliveira Mafalda, Saura Cristina, Schmid Peter, Turner Nicholas C, Varga Andreea, Gendreau Steven, Hwang Michael S, Kuang Zheng, Lau Jeffrey T, Lin Eva, Pham Trang, Maddalo Danilo, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Martin Scott, Sodir Nicole M, Sokol Ethan S, Whitfield Zachary J, Wong Alice, Yauch Robert L, Aimi Junko, Cheeti Sravanthi, Fredrickson Jill, Hilz Stephanie, Hafner Marc, Hutchinson Katherine E, Jin Yanling, Peters Ubong, Zingg Daniel, Royer-Joo Stephanie, Shankar Noopur, Schutzman Jennifer L, Jhaveri Komal L, Dey Anwesha

Synthesis and Biological Evaluation of Colibactin Derivatives

大肠杆菌素衍生物的合成及生物学评价

Airan, Yougant; Fedorova, Olga; Heer, Collin; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Bindra, Ranjit S; Herzon, Seth B

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.

KDM4C 抑制剂通过促进组织蛋白酶 L 介导的组蛋白 H3 裂解来阻断基底型乳腺癌的肿瘤生长

Li Zheqi, Peluffo Guillermo, Stevens Laura E, Qiu Xintao, Seehawer Marco, Tawawalla Amatullah, Huang Xiao-Yun, Egri Shawn B, Raval Shaunak, McFadden Maeve, D'Santos Clive S, Papachristou Eva, Kingston Natalie L, Nishida Jun, Evans Kyle E, Seo Ji-Heui, Clement Kendell, Temko Daniel, Ekram Muhammad, Li Rong, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Simeonov Anton, Kales Stephen C, Rai Ganesha, Lal-Nag Madhu, Maloney David J, Jadhav Ajit, Michor Franziska, Meissner Alex, Balko Justin M, Carroll Jason S, Freedman Matthew L, Jaffe Jacob D, Papanastasiou Malvina, Long Henry W, Polyak Kornelia

Identification of a Selective Anticancer Agent from a Collection of Complex-And-Diverse Compounds Synthesized from Stevioside

从甜菊苷合成的一系列复杂多样的化合物中鉴定出一种选择性抗癌剂

Schaaf, Rachel E; Quirke, Jonathan C K; Ghavami, Maryam; Tonogai, Emily J; Lee, Hyang Yeon; Barlock, Samantha L; Trzupek, Thomas R; Abo, Kyle R; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Hergenrother, Paul J

An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer

一种不依赖于特定等位基因的突变型KRAS抑制剂可抑制肿瘤维持信号并重编程胰腺癌的肿瘤免疫。

McAndrews, Kathleen M; Paradiso, Francesca; Stalnecker, Clint A; Chellakkan, Benson S; Thege, Fredrik I; Peng, David H; Moreno Diaz, Barbara A; Sugimoto, Hikaru; Patel, Sarah I; Mahadevan, Krishnan K; Kirtley, Michelle L; Wills, Danielle; Sockwell, Amari M; Fonseca, Andre Luis F; Liu, Yunhe; Rajapakshe, Kimal I; Yee, Nathaniel G; Tran, Phuong Thao; Omar, Huda Alchikh; Tedeschi, Antonio; Schischlik-Siegl, Fiorella; Boghossian, Andrew S; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Rudolph, Dorothea; Aichinger, Martin; Ebner, Florian; Artemov, Artem V; Lipp, Jesse; Pisarsky, Laura; Herrmann, Valerie Laura; Park, John; Rippmann, Jörg F; Schaaf, Otmar; Chandler, Vanessa; Williams, Mariah; Deckard, Charles E; Wang, Linghua; Der, Channing J; Vellano, Christopher; Guerrero, Paola A; Heffernan, Timothy P; Kalluri, Raghu; Maitra, Anirban

Tegavivint triggers TECR-dependent nonapoptotic cancer cell death

Tegavivint 诱导 TECR 依赖性非凋亡性癌细胞死亡

Leak, Logan; Wang, Ziwei; Joseph, Alby J; Johnson, Brianna; Chan, Alyssa A; Decosto, Cassandra M; Magtanong, Leslie; Ko, Pin-Joe; Lee, Weaverly Colleen; Ritho, Joan; Manukian, Sophia; Millner, Alec; Chitkara, Shweta; Salinas, Jennifer J; Skouta, Rachid; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Myers, Chad L; Moffat, Jason; Boone, Charles; Bensinger, Steven J; Nathanson, David A; Atilla-Gokcumen, G Ekin; Moding, Everett J; Dixon, Scott J

The contribution of cyclic imide stereoisomers on cereblon-dependent activity

环状酰亚胺立体异构体对脑蛋白依赖性活性的影响

Amako, Yuka; Ichikawa, Saki; Lloyd, Hannah C; Payne, N Connor; Lin, Zhi; Boghossian, Andrew S; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Zhu, Qian; Budnik, Bogdan; Mazitschek, Ralph; Woo, Christina M

Targeted degradation of CDK9 potently disrupts the MYC-regulated network.

靶向降解 CDK9 可有效破坏 MYC 调控网络

Toure Mohammed A, Motoyama Keisuke, Xiang Yichen, Urgiles Julie, Kabinger Florian, Koglin Ann-Sophie, Iyer Ramya S, Gagnon Kaitlyn, Kumar Amruth, Ojeda Samuel, Harrison Drew A, Rees Matthew G, Roth Jennifer A, Ott Christopher J, Schiavoni Richard, Whittaker Charles A, Levine Stuart S, White Forest M, Calo Eliezer, Richters Andre, Koehler Angela N