日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Low-risk MDS-A spotlight on precision medicine for SF3B1-mutated patients

低风险MDS——聚焦SF3B1突变患者的精准医疗

Burke, Shoshana; Chowdhury, Onima; Rouault-Pierre, Kevin

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

DEK::NUP214 作为 XPO1 依赖性转录激活因子,激活白血病必需基因的表达。

Kaya, Fadimana; Bewicke-Copley, Findlay; Miettinen, Juho J; Casado, Pedro; Leddy, Eve; Deniz, Özgen; Lavallée, Vincent-Philippe; Philippe, Celine; Zheng, Jiexin; Grebien, Florian; Khan, Naeem; Krizsán, Szilvia; Saad, Joseph; Nolin-Lapalme, Alexis; Hébert, Josée; Lemieux, Sébastien; Audemard, Eric; Matthews, Janet; Grantham, Marianne; Di Bella, Doriana; Wennerberg, Krister; Parsons, Alun; Gribben, John; Cavenagh, James D; Freeman, Sylvie D; Bödör, Csaba; Sauvageau, Guy; Wang, Jun; Llamas-Sillero, Pilar; Cazier, Jean-Baptiste; Taussig, David C; Bonnet, Dominique; Cutillas, Pedro R; Heckman, Caroline A; Fitzgibbon, Jude; Rouault-Pierre, Kevin; Rio-Machin, Ana

Succinyl-coenzyme A: a key metabolite and succinyl group donor in erythropoiesis

琥珀酰辅酶A:红细胞生成过程中的关键代谢物和琥珀酰基供体

Rouault-Pierre, Kevin

Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

硬脂酰辅酶A去饱和酶抑制剂对具有高水平从头脂肪酸生物合成和去饱和作用的急性髓系白血病具有毒性。

Dembitz, Vilma; Lawson, Hannah; Burt, Richard; Natani, Sirisha; Philippe, Céline; James, Sophie C; Atkinson, Samantha; Durko, Jozef; Wang, Lydia M; Campos, Joana; Magee, Aoife M S; Woodley, Keith; Austin, Michael J; Rio-Machin, Ana; Casado, Pedro; Bewicke-Copley, Findlay; Rodriguez Blanco, Giovanny; Pereira-Martins, Diego; Oudejans, Lieve; Boet, Emeline; von Kriegsheim, Alex; Schwaller, Juerg; Finch, Andrew J; Patel, Bela; Sarry, Jean-Emmanuel; Tamburini, Jerome; Schuringa, Jan Jacob; Hazlehurst, Lori; Copland Iii, John A; Yuneva, Mariia; Peck, Barrie; Cutillas, Pedro; Fitzgibbon, Jude; Rouault-Pierre, Kevin; Kranc, Kamil; Gallipoli, Paolo

Pivotal role of the endoplasmic reticulum stress-related XBP1s/miR-22/SIRT1 axis in acute myeloid leukemia apoptosis and response to chemotherapy

内质网应激相关 XBP1s/miR-22/SIRT1 轴在急性髓系白血病细胞凋亡和化疗反应中的关键作用

Céline Philippe #, Manon Jaud #, Kelly Féral, Alexandre Gay, Loïc Van Den Berghe, Manon Farce, Marina Bousquet, Stéphane Pyronnet, Laurent Mazzolini, Kevin Rouault-Pierre, Christian Touriol

The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

SF3B1的E592K变体造成独特的RNA剪接错误,并与无环状铁粒幼细胞的高危MDS相关。

Choi, In Young; Ling, Jonathan P; Zhang, Jian; Helmenstine, Eric; Walter, Wencke; Tsakiroglou, Panagiotis; Bergman, Riley E; Philippe, Céline; Manley, James L; Rouault-Pierre, Kevin; Li, Bing; Wiseman, Daniel H; Batta, Kiran; Ouseph, Madhu; Bernard, Elsa; Dubner, Benjamin; Li, Xiao; Haferlach, Torsten; Koget, Anna; Fazal, Salman; Jain, Tania; Gocke, Christopher D; DeZern, Amy E; Dalton, William Brian

Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes

整合磷酸化蛋白质组学定义了两组生物学上不同的 KMT2A 重排急性髓系白血病,它们具有不同的药物反应表型

Pedro Casado, Ana Rio-Machin, Juho J Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsan, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C Taussig, Csaba Bödör, John Gribben, Caroline Heckman, Jude Fitzgibbon, Pedro R Cutillas

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death

甘露糖代谢抑制通过诱导铁死亡使急性髓系白血病细胞对治疗更加敏感

Keith Woodley ,Laura S Dillingh ,George Giotopoulos ,Pedro Madrigal ,Kevin M Rattigan ,Céline Philippe ,Vilma Dembitz ,Aoife M S Magee ,Ryan Asby ,Louie N van de Lagemaat ,Christopher Mapperley ,Sophie C James ,Jochen H M Prehn ,Konstantinos Tzelepis ,Kevin Rouault-Pierre ,George S Vassiliou ,Kamil R Kranc ,G Vignir Helgason ,Brian J P Huntly ,Paolo Gallipoli

CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny

CRISPR/dCas9 DNA 甲基化编辑在人类造血过程中可遗传并塑造免疫后代

Emily A Saunderson, Hector Huerga Encabo, Julie Devis, Kevin Rouault-Pierre, Marion Piganeau, Christopher G Bell, John G Gribben, Dominique Bonnet, Gabriella Ficz

The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts

SF3B1 的 E592K 变体产生独特的 RNA 错误剪接,并与无环状铁粒幼细胞的高风险 MDS 相关

In Young Choi, Jonathan Ling, Jian Zhang, Eric Helmenstine, Wencke Walter, Riley Bergman, Céline Philippe, James Manley, Kevin Rouault-Pierre, Bing Li, Daniel Wiseman, Madhu Ouseph, Elsa Bernard, Xiao Li, Torsten Haferlach, Salman Fazal, Tania Jain, Christopher Gocke, Amy DeZern, W Brian Dalton